AU2017320088B2 - Anti-influenza virus pyrimidine derivative - Google Patents

Anti-influenza virus pyrimidine derivative Download PDF

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Publication number
AU2017320088B2
AU2017320088B2 AU2017320088A AU2017320088A AU2017320088B2 AU 2017320088 B2 AU2017320088 B2 AU 2017320088B2 AU 2017320088 A AU2017320088 A AU 2017320088A AU 2017320088 A AU2017320088 A AU 2017320088A AU 2017320088 B2 AU2017320088 B2 AU 2017320088B2
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AU
Australia
Prior art keywords
compound
group
acceptable salt
pharmaceutically acceptable
cooh
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AU2017320088A
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English (en)
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AU2017320088A1 (en
Inventor
Kevin X. Chen
Shuhui Chen
Xiaoxin Chen
Jian Li
Peng Li
Chaofeng LONG
Xuanjia Peng
Jingjing Wang
Cheng Xie
Jian Xiong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Raynovent Biotech Co Ltd
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Guangdong Raynovent Biotech Co Ltd
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Publication of AU2017320088A1 publication Critical patent/AU2017320088A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2017320088A 2016-09-05 2017-09-05 Anti-influenza virus pyrimidine derivative Active AU2017320088B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201610804101.3 2016-09-05
CN201610804101 2016-09-05
CN201611238759 2016-12-28
CN201611238759.9 2016-12-28
PCT/CN2017/100461 WO2018041263A1 (zh) 2016-09-05 2017-09-05 抗流感病毒嘧啶衍生物

Publications (2)

Publication Number Publication Date
AU2017320088A1 AU2017320088A1 (en) 2019-04-18
AU2017320088B2 true AU2017320088B2 (en) 2020-01-30

Family

ID=61300177

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017320088A Active AU2017320088B2 (en) 2016-09-05 2017-09-05 Anti-influenza virus pyrimidine derivative

Country Status (14)

Country Link
US (4) US11136319B2 (enExample)
EP (1) EP3502112B1 (enExample)
JP (1) JP6838773B2 (enExample)
KR (1) KR102312088B1 (enExample)
CN (3) CN110627784B (enExample)
AU (1) AU2017320088B2 (enExample)
CA (1) CA3035680C (enExample)
DK (1) DK3502112T3 (enExample)
IL (1) IL265166B (enExample)
MX (1) MX394277B (enExample)
RU (1) RU2727772C1 (enExample)
SG (1) SG11201901894TA (enExample)
WO (1) WO2018041263A1 (enExample)
ZA (1) ZA201901886B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018033082A1 (en) 2016-08-16 2018-02-22 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
WO2018041091A1 (en) 2016-08-30 2018-03-08 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
US11136319B2 (en) * 2016-09-05 2021-10-05 Guangdong Raynovent Biotech Co., Ltd. Anti-influenza virus pyrimidine derivative
US10987354B2 (en) 2016-12-15 2021-04-27 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
WO2018127096A1 (en) * 2017-01-05 2018-07-12 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
WO2018157830A1 (en) 2017-03-02 2018-09-07 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
US11535613B2 (en) 2018-03-05 2022-12-27 Guangdong Raynovent Biotech Co., Ltd. Crystal form and salt form of pyridoimidazole compound and preparation method therefor
CN110590768B (zh) * 2018-06-13 2021-02-26 银杏树药业(苏州)有限公司 杂环化合物、其组合物及其作为抗流感病毒药物的应用
CN114127068B (zh) * 2019-07-22 2024-05-28 广东众生睿创生物科技有限公司 嘧啶衍生物的优势盐型及其晶型
CN114502150B (zh) * 2019-09-10 2023-03-24 广东众生睿创生物科技有限公司 一种用于治疗病毒性感冒的药物组合物及其制剂
CN111454166B (zh) * 2019-12-30 2021-02-26 广东莱佛士制药技术有限公司 制备(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法
CN113116899B (zh) * 2020-03-06 2022-12-20 广东众生睿创生物科技有限公司 一种用于治疗流感的药物组合物及含有该药物组合物的制剂
CN116323593B (zh) * 2020-10-29 2025-06-03 广东众生睿创生物科技有限公司 一种嘧啶衍生物的晶型及其制备方法
CN114569562B (zh) * 2020-12-01 2025-07-29 南通诺泰生物医药技术有限公司 一种抗流感病毒的药物组合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103492381A (zh) * 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
CN104922128A (zh) * 2009-06-17 2015-09-23 沃泰克斯药物股份有限公司 流感病毒复制抑制剂
WO2017097234A1 (en) * 2015-12-09 2017-06-15 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
WO2017133670A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130102600A1 (en) * 2011-10-21 2013-04-25 F. Hoffmann-La Roche Ltd Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease
KR102488479B1 (ko) * 2014-08-08 2023-01-12 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 인플루엔자 바이러스 감염에 사용하기 위한 인돌
WO2017133657A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza
WO2018033082A1 (en) 2016-08-16 2018-02-22 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
US11136319B2 (en) * 2016-09-05 2021-10-05 Guangdong Raynovent Biotech Co., Ltd. Anti-influenza virus pyrimidine derivative
US11535613B2 (en) * 2018-03-05 2022-12-27 Guangdong Raynovent Biotech Co., Ltd. Crystal form and salt form of pyridoimidazole compound and preparation method therefor
CN114127068B (zh) * 2019-07-22 2024-05-28 广东众生睿创生物科技有限公司 嘧啶衍生物的优势盐型及其晶型

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104922128A (zh) * 2009-06-17 2015-09-23 沃泰克斯药物股份有限公司 流感病毒复制抑制剂
CN103492381A (zh) * 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
WO2017097234A1 (en) * 2015-12-09 2017-06-15 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
WO2017133670A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza

Also Published As

Publication number Publication date
CN109790159B (zh) 2020-01-14
CN110623958B (zh) 2022-05-17
CA3035680A1 (en) 2018-03-08
US11725009B2 (en) 2023-08-15
US20220135558A1 (en) 2022-05-05
NZ751964A (en) 2021-02-26
MX2019002541A (es) 2019-07-01
WO2018041263A1 (zh) 2018-03-08
US20210032238A1 (en) 2021-02-04
MX394277B (es) 2025-03-24
US12319692B2 (en) 2025-06-03
SG11201901894TA (en) 2019-04-29
EP3502112A1 (en) 2019-06-26
CN110627784B (zh) 2021-09-21
KR102312088B1 (ko) 2021-10-14
IL265166A (en) 2019-05-30
US11136319B2 (en) 2021-10-05
US20230339943A1 (en) 2023-10-26
KR20190056380A (ko) 2019-05-24
US20250250275A1 (en) 2025-08-07
AU2017320088A1 (en) 2019-04-18
ZA201901886B (en) 2021-01-27
DK3502112T3 (da) 2025-09-22
EP3502112A4 (en) 2019-06-26
BR112019004420A2 (pt) 2019-05-28
RU2727772C1 (ru) 2020-07-23
CN110627784A (zh) 2019-12-31
JP6838773B2 (ja) 2021-03-03
CA3035680C (en) 2023-05-02
EP3502112B1 (en) 2025-07-02
JP2019529386A (ja) 2019-10-17
IL265166B (en) 2021-09-30
CN110623958A (zh) 2019-12-31
CN109790159A (zh) 2019-05-21

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