AU2017319218B2 - Modified factor H binding protein - Google Patents

Modified factor H binding protein Download PDF

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Publication number
AU2017319218B2
AU2017319218B2 AU2017319218A AU2017319218A AU2017319218B2 AU 2017319218 B2 AU2017319218 B2 AU 2017319218B2 AU 2017319218 A AU2017319218 A AU 2017319218A AU 2017319218 A AU2017319218 A AU 2017319218A AU 2017319218 B2 AU2017319218 B2 AU 2017319218B2
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AU
Australia
Prior art keywords
gly
ala
lys
leu
ser
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Active
Application number
AU2017319218A
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English (en)
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AU2017319218A1 (en
AU2017319218A2 (en
Inventor
Christoph M TANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of AU2017319218A1 publication Critical patent/AU2017319218A1/en
Publication of AU2017319218A2 publication Critical patent/AU2017319218A2/en
Application granted granted Critical
Publication of AU2017319218B2 publication Critical patent/AU2017319218B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AU2017319218A 2016-08-31 2017-08-31 Modified factor H binding protein Active AU2017319218B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1614687.0 2016-08-31
GBGB1614687.0A GB201614687D0 (en) 2016-08-31 2016-08-31 fHbp scaffold
PCT/GB2017/052535 WO2018042178A1 (en) 2016-08-31 2017-08-31 Modified factor h binding protein

Publications (3)

Publication Number Publication Date
AU2017319218A1 AU2017319218A1 (en) 2019-04-18
AU2017319218A2 AU2017319218A2 (en) 2019-05-02
AU2017319218B2 true AU2017319218B2 (en) 2021-10-28

Family

ID=57119942

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017319218A Active AU2017319218B2 (en) 2016-08-31 2017-08-31 Modified factor H binding protein

Country Status (12)

Country Link
EP (1) EP3506934A1 (OSRAM)
JP (1) JP7525093B2 (OSRAM)
KR (1) KR102643280B1 (OSRAM)
CN (1) CN109890412B (OSRAM)
AU (1) AU2017319218B2 (OSRAM)
BR (1) BR112019003957A2 (OSRAM)
CA (1) CA3035159A1 (OSRAM)
GB (2) GB201614687D0 (OSRAM)
IL (1) IL265078B2 (OSRAM)
MX (1) MX2019002248A (OSRAM)
WO (1) WO2018042178A1 (OSRAM)
ZA (1) ZA201901862B (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110903400A (zh) * 2019-11-08 2020-03-24 苏州微超生物科技有限公司 B群脑膜炎球菌fHBP多变体融合蛋白及其制备方法与应用
CN111533792B (zh) 2020-07-07 2020-10-16 康希诺生物股份公司 一种定点突变的载体蛋白及其在制备疫苗中的用途
CN116323680A (zh) * 2020-09-29 2023-06-23 出光兴产株式会社 肽标签和包含其的附加有标签的蛋白
IN202321021121A (OSRAM) * 2023-03-24 2024-04-19

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006024954A2 (en) * 2004-09-01 2006-03-09 Novartis Vaccines And Diagnostics Srl Domains and epitopes of meningococcal protein nmb1870
WO2007060548A2 (en) * 2005-11-25 2007-05-31 Novartis Vaccines And Diagnostics Srl Chimeric, hybrid and tandem polypeptides of meningococcal nmb1870
WO2009114485A2 (en) * 2008-03-10 2009-09-17 Children's Hospital & Research Center At Oakland Chimeric factor h binding proteins (fhbp) containing a heterologous b domain and methods of use
WO2011024072A2 (en) * 2009-08-27 2011-03-03 Novartis Ag Hybrid polypeptides including meningococcal fhbp sequences

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201015132D0 (en) * 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
AU2015352404A1 (en) * 2014-11-28 2017-05-18 Janssen Vaccines & Prevention B.V. Meningitis B vaccine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006024954A2 (en) * 2004-09-01 2006-03-09 Novartis Vaccines And Diagnostics Srl Domains and epitopes of meningococcal protein nmb1870
WO2007060548A2 (en) * 2005-11-25 2007-05-31 Novartis Vaccines And Diagnostics Srl Chimeric, hybrid and tandem polypeptides of meningococcal nmb1870
WO2009114485A2 (en) * 2008-03-10 2009-09-17 Children's Hospital & Research Center At Oakland Chimeric factor h binding proteins (fhbp) containing a heterologous b domain and methods of use
WO2011024072A2 (en) * 2009-08-27 2011-03-03 Novartis Ag Hybrid polypeptides including meningococcal fhbp sequences

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCARSELLI MARIA et al: "Rational design of a meningococcal antigen ingucing broad protective immunity". Science Translational Medi, AAAS- American Association for the advancement of Science, US. vol. 3, no. 91, 13 July 2011 *

Also Published As

Publication number Publication date
IL265078A (OSRAM) 2019-04-30
IL265078B1 (en) 2023-04-01
GB2568440B (en) 2022-08-17
NZ751995A (en) 2024-03-22
BR112019003957A2 (pt) 2019-06-25
CN109890412A (zh) 2019-06-14
ZA201901862B (en) 2020-09-30
WO2018042178A1 (en) 2018-03-08
CN109890412B (zh) 2025-04-04
MX2019002248A (es) 2019-09-18
AU2017319218A1 (en) 2019-04-18
CA3035159A1 (en) 2018-03-08
GB201903866D0 (en) 2019-05-08
IL265078B2 (en) 2023-08-01
US20220112249A1 (en) 2022-04-14
EP3506934A1 (en) 2019-07-10
JP7525093B2 (ja) 2024-07-30
AU2017319218A2 (en) 2019-05-02
GB201614687D0 (en) 2016-10-12
KR102643280B1 (ko) 2024-03-05
GB2568440A (en) 2019-05-15
KR20190064577A (ko) 2019-06-10
JP2019526261A (ja) 2019-09-19

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT FILED 26 MAR 2019

FGA Letters patent sealed or granted (standard patent)