AU2017311542B2 - Alkaline stable Fc—binding proteins for affinity chromatography - Google Patents

Alkaline stable Fc—binding proteins for affinity chromatography Download PDF

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Publication number
AU2017311542B2
AU2017311542B2 AU2017311542A AU2017311542A AU2017311542B2 AU 2017311542 B2 AU2017311542 B2 AU 2017311542B2 AU 2017311542 A AU2017311542 A AU 2017311542A AU 2017311542 A AU2017311542 A AU 2017311542A AU 2017311542 B2 AU2017311542 B2 AU 2017311542B2
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protein
ala
binding
gln
binding protein
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AU2017311542A1 (en
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Erik Fiedler
Ulrich Haupts
Paul KNICK
Maren MEYSING
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Repligen Corp
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Repligen Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AU2017311542A 2016-08-11 2017-08-07 Alkaline stable Fc—binding proteins for affinity chromatography Active AU2017311542B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16183710.9 2016-08-11
EP16183710 2016-08-11
EP16205707.9 2016-12-21
EP16205707 2016-12-21
PCT/EP2017/069979 WO2018029158A1 (en) 2016-08-11 2017-08-07 Alkaline stable fc—binding proteins for affinity chromatography

Publications (2)

Publication Number Publication Date
AU2017311542A1 AU2017311542A1 (en) 2019-02-07
AU2017311542B2 true AU2017311542B2 (en) 2021-06-24

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AU2017311542A Active AU2017311542B2 (en) 2016-08-11 2017-08-07 Alkaline stable Fc—binding proteins for affinity chromatography
AU2017311541A Active AU2017311541B2 (en) 2016-08-11 2017-08-07 Novel alkaline stable immunoglobulin-binding proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017311541A Active AU2017311541B2 (en) 2016-08-11 2017-08-07 Novel alkaline stable immunoglobulin-binding proteins

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US (4) US11230576B2 (OSRAM)
EP (4) EP4177260A1 (OSRAM)
JP (3) JP6951417B2 (OSRAM)
KR (3) KR102578256B1 (OSRAM)
CN (4) CN109476712B (OSRAM)
AU (2) AU2017311542B2 (OSRAM)
CA (2) CA3030208A1 (OSRAM)
DK (1) DK3497117T5 (OSRAM)
LT (1) LT3497117T (OSRAM)
SG (1) SG11201901066UA (OSRAM)
WO (2) WO2018029157A1 (OSRAM)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3253785T3 (da) 2015-02-06 2019-07-08 Navigo Proteins Gmbh Hidtil ukendte egfr-bindingsproteiner
ES2916101T3 (es) 2015-07-16 2022-06-28 Navigo Proteins Gmbh Nuevas proteínas de unión a inmunoglobulina y su uso en la purificación por afinidad
JP2018520675A (ja) 2015-07-20 2018-08-02 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法
AU2017260274A1 (en) 2016-05-04 2018-11-01 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
AU2017311542B2 (en) 2016-08-11 2021-06-24 Repligen Corporation Alkaline stable Fc—binding proteins for affinity chromatography
EP4491268A3 (en) 2017-08-07 2025-04-09 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
EP3546476A1 (en) * 2018-03-26 2019-10-02 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
EP3521304B9 (en) * 2018-02-01 2023-10-04 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
WO2019091918A1 (en) 2017-11-07 2019-05-16 Navigo Proteins Gmbh Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer
US12466857B2 (en) * 2018-11-12 2025-11-11 Navigo Proteins Gmbh Triple-helical polypeptides lacking binding affinity for the Fc domain of immunoglobulin and uses thereof
EP3650465A1 (en) 2018-11-12 2020-05-13 Navigo Proteins Gmbh Novel populations of polypeptides having a triple-helical structure
BR112021013026A2 (pt) * 2019-02-01 2021-10-13 Navigo Proteins Gmbh Proteínas de ligação à imunoglobulina, matriz de separação por afinidade, uso da proteína de ligação à imunoglobulina, e método de purificação por afinidade de uma proteína compreendendo uma sequência de imunoglobulina
GB201904125D0 (en) 2019-03-26 2019-05-08 Ge Healthcare Bio Sciences Ab Method for sanitization of a chromatography column
JP7432813B2 (ja) * 2019-09-10 2024-02-19 東ソー株式会社 免疫グロブリン結合性タンパク質
US12286458B2 (en) 2019-12-17 2025-04-29 Navigo Proteins Gmbh Binding proteins for the enzyme acid alpha glucosidase (GAA) and uses thereof
WO2021165395A1 (en) * 2020-02-21 2021-08-26 Navigo Proteins Gmbh Affinity ligand for the soluble part of fibroblast growth factor receptor 3 (sfgfr3)
EP3875472A1 (en) * 2020-03-06 2021-09-08 Navigo Proteins Gmbh Novel immunoglobulin binding polypeptides
CA3183655A1 (en) * 2020-06-23 2021-12-30 Mathias KAHL Binding protein specific for the spike protein of severe acute respiratory syndrome corona virus 2 (sars-cov-2)
US20230295223A1 (en) * 2020-07-15 2023-09-21 Navigo Proteins Gmbh Immunoglobulin binding proteins for affinity purification
JP2023547340A (ja) * 2020-11-09 2023-11-10 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｉｉ型コラーゲン結合タンパク質
EP4001301A1 (en) * 2020-11-13 2022-05-25 Navigo Proteins Gmbh Binding protein for complement factor h (cfh)
EP4380955A1 (en) * 2021-08-06 2024-06-12 Roche Diagnostics GmbH Chimeric igg-fc-binding ligand polypeptide and uses thereof for igg affinity purification
GB202113626D0 (en) 2021-09-24 2021-11-10 Cytiva Bioprocess R & D Ab FC binding polypeptides
CN116675729A (zh) * 2021-12-21 2023-09-01 百林科(兰州)新材料有限公司 耐碱蛋白A变体去除样品中IgG抗体的应用
CN113999294B (zh) * 2021-12-30 2022-03-29 苏州纳微科技股份有限公司 免疫球蛋白结合蛋白及其应用
CN114409748A (zh) * 2022-01-28 2022-04-29 博格隆(浙江)生物技术有限公司 蛋白a的b结构域和z结构域突变体及其应用
GB202203478D0 (en) 2022-03-14 2022-04-27 Cytiva Bioprocess R & D Ab Vh3 binding polypeptides
KR20250112269A (ko) * 2022-12-16 2025-07-23 나피고 프로타인스 게엠베하 친화성 크로마토그래피를 위한 신규한 리간드
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells
EP4541444A1 (en) * 2023-10-20 2025-04-23 Cytiva BioProcess R&D AB Fusion protein for affinity capture

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2690173A1 (en) * 2011-03-25 2014-01-29 Kaneka Corporation Protein for affinity-separation matrix
WO2015005859A1 (en) * 2013-07-10 2015-01-15 Ge Healthcare Bio-Sciences Ab Mutated immunoglobulin-binding polypeptides
WO2016079033A1 (en) * 2014-11-17 2016-05-26 Ge Healthcare Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
SE9103701D0 (sv) 1991-12-13 1991-12-13 Kabi Pharmacia Ab Apolipoprotein
US5629167A (en) * 1994-04-19 1997-05-13 Biocine S.P.A. Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
CA2171611C (en) * 1994-07-21 2001-05-29 Sheena Loosmore Analog of haemophilus hin47 with reduced protease activity
US5958684A (en) 1995-10-02 1999-09-28 Van Leeuwen; Frederik Willem Diagnosis of neurodegenerative disease
CA2235223A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
US5789166A (en) 1995-12-08 1998-08-04 Stratagene Circular site-directed mutagenesis
GB9610967D0 (en) 1996-05-24 1996-07-31 Cambridge Antibody Tech Specific binding members,materials and methods
FR2761689B1 (fr) 1997-04-02 1999-06-25 Transgene Sa Fibre adenovirale modifiee et adenovirus cibles
ATE250668T1 (de) 1997-05-28 2003-10-15 Discerna Ltd Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen
EP0985039B1 (en) 1997-06-12 2008-02-20 Novartis International Pharmaceutical Ltd. Artificial antibody polypeptides
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
TWI259837B (en) 1998-05-11 2006-08-11 Eidgenossische Tech Hochscule Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
US20030045681A1 (en) 1998-05-11 2003-03-06 Anthony J. Zelano Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
EP1259548A1 (en) 2000-02-24 2002-11-27 Eidgenössische Technische Hochschule Zürich Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis
WO2001062298A2 (en) 2000-02-24 2001-08-30 Philogen S.R.L. Compositions and methods for treatment of angiogenesis in pathological lesions
US6799121B2 (en) 2000-03-30 2004-09-28 York University Sequencing of peptides by mass spectrometry
US20110179531A1 (en) 2000-05-09 2011-07-21 Kovalic David K Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
US20030073623A1 (en) 2001-07-30 2003-04-17 Drmanac Radoje T. Novel nucleic acid sequences obtained from various cDNA libraries
CA2473144C (en) * 2002-02-05 2013-05-28 Genentech, Inc. Protein purification
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
US20040043386A1 (en) 2002-08-30 2004-03-04 Todd Pray Methods and compositions for functional ubiquitin assays
EP1591527B1 (en) 2003-01-23 2015-08-26 Ono Pharmaceutical Co., Ltd. Substance specific to human pd-1
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
CA2544764A1 (en) 2003-11-04 2005-05-19 Yale University Protein binding miniature proteins
US7393918B2 (en) 2003-12-11 2008-07-01 Yale University Protein binding miniature proteins and uses thereof
DE10360483B4 (de) 2003-12-22 2007-11-15 Scil Proteins Gmbh Expressionsvektor und dessen Verwendung
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
DE102004049479A1 (de) 2004-10-11 2006-04-13 Scil Proteins Gmbh Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
JP2006304633A (ja) * 2005-04-26 2006-11-09 Apro Life Science Institute Inc イムノグロブリン結合タンパク質
ATE459648T1 (de) 2005-05-11 2010-03-15 Philogen Spa Fusionsprotein von antikörper l19 gegen fibronectin ed-b und interleukin 12
MY185597A (en) * 2005-09-20 2021-05-24 Avantor Performance Mat Inc Vegetarian protein a preparation and methods thereof
ATE463512T1 (de) 2005-11-09 2010-04-15 Morphosys Ag Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern
EP1842553A1 (en) 2006-04-07 2007-10-10 Bayer Schering Pharma Aktiengesellschaft Combination of an anti-EDb fibronectin domain antibody/IL2 fusion protein and a further small molecule
EA200802289A1 (ru) 2006-05-08 2009-04-28 Филоджен Спа Направляемые к мишени антителами цитокины для терапии
EP1892248A1 (en) 2006-08-21 2008-02-27 Eidgenössische Technische Hochschule Zürich Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase
EP2066419B1 (en) * 2006-09-29 2015-11-11 GE Healthcare Bio-Sciences AB Chromatography ligand comprising domain c from staphyloccocus aureus protein a for antibody isolation
EP1925664A1 (en) 2006-11-15 2008-05-28 Scil proteins GmbH Artificial binding proteins based on a modified alpha helical region of ubiquitin
EP1955712A1 (en) 2007-02-09 2008-08-13 Scil proteins GmbH Multimeric conjugate
EP2310509B1 (en) 2008-07-21 2015-01-21 Apogenix GmbH Tnfsf single chain molecules
US8592555B2 (en) * 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
EP2367843B1 (en) 2009-12-14 2014-10-08 Scil Proteins GmbH Modified ubiquitin proteins having a specific binding activity for the extradomain b of fibronectin
AU2011230313B2 (en) * 2010-03-24 2015-01-22 Kaneka Corporation Protein capable of binding specifically to immunoglobulin, and immunoglobulin-binding affinity ligand
SG186552A1 (en) 2011-06-08 2013-01-30 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
WO2012171541A1 (en) 2011-06-15 2012-12-20 Scil Proteins Gmbh Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins
WO2012172055A1 (en) 2011-06-15 2012-12-20 Scil Proteins Gmbh Dimeric binding proteins based on modified ubiquitins
US20150183846A1 (en) 2012-06-13 2015-07-02 Scil Proteins Gmbh Human fusion proteins comprising single chain tnfalpha and targeting domains
AU2013318928A1 (en) 2012-09-21 2015-04-09 Kaneka Corporation Protein ligand for affinity isolation matrix
EP2727942A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Bispecific antibodies against human EGFR, HER2, and HER3
EP2738180A1 (en) 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
WO2014094799A1 (en) 2012-12-19 2014-06-26 Scil-Proteins-Gmbh Ubiquitin moieties as a means for prolonging serum half-life
KR102236367B1 (ko) 2013-07-26 2021-04-05 삼성전자주식회사 DARPin을 포함하는 이중 특이 키메라 단백질
DK3253795T3 (da) 2015-02-06 2019-07-29 Navigo Proteins Gmbh Hidtil ukendte bindende proteiner, der omfatter et ubiquitin-mutein, og antistoffer eller antistoffragmenter
DK3253785T3 (da) 2015-02-06 2019-07-08 Navigo Proteins Gmbh Hidtil ukendte egfr-bindingsproteiner
ES2916101T3 (es) 2015-07-16 2022-06-28 Navigo Proteins Gmbh Nuevas proteínas de unión a inmunoglobulina y su uso en la purificación por afinidad
CA2991814A1 (en) 2015-07-20 2017-01-26 Navigo Proteins Gmbh Her2 binding proteins based on di-ubiquitin muteins
JP2018520675A (ja) 2015-07-20 2018-08-02 ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ ジユビキチン変異タンパク質をベースとした新規結合タンパク質及びその生成方法
AU2017260274A1 (en) 2016-05-04 2018-11-01 Navigo Proteins Gmbh Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker
AU2017311542B2 (en) 2016-08-11 2021-06-24 Repligen Corporation Alkaline stable Fc—binding proteins for affinity chromatography
EP3521304B9 (en) 2018-02-01 2023-10-04 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
EP4491268A3 (en) 2017-08-07 2025-04-09 Repligen Corporation Fc binding proteins with cysteine in the c-terminal helical region
WO2019091918A1 (en) 2017-11-07 2019-05-16 Navigo Proteins Gmbh Fusion proteins with specificity for ed-b and long serum half-life for diagnosis or treatment of cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2690173A1 (en) * 2011-03-25 2014-01-29 Kaneka Corporation Protein for affinity-separation matrix
WO2015005859A1 (en) * 2013-07-10 2015-01-15 Ge Healthcare Bio-Sciences Ab Mutated immunoglobulin-binding polypeptides
WO2016079033A1 (en) * 2014-11-17 2016-05-26 Ge Healthcare Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides

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EP3497117B1 (en) 2024-01-24
CN109476712B (zh) 2022-08-02
KR102578256B1 (ko) 2023-09-15
WO2018029158A1 (en) 2018-02-15
KR20230133943A (ko) 2023-09-19
CA3031858A1 (en) 2018-02-15
EP4324840A2 (en) 2024-02-21
JP6951417B2 (ja) 2021-10-20
EP3497118B1 (en) 2022-09-14
AU2017311541B2 (en) 2020-08-13
WO2018029157A1 (en) 2018-02-15
DK3497117T5 (da) 2024-09-02
JP2019531055A (ja) 2019-10-31
EP4177260A1 (en) 2023-05-10
CN116333065A (zh) 2023-06-27
EP4324840A3 (en) 2024-04-24
JP7181612B2 (ja) 2022-12-01
EP3497118A1 (en) 2019-06-19
CN117736281A (zh) 2024-03-22
KR20190044059A (ko) 2019-04-29
SG11201901066UA (en) 2019-03-28
LT3497117T (lt) 2024-05-10
US20210206815A1 (en) 2021-07-08
US20190300568A1 (en) 2019-10-03
CA3030208A1 (en) 2018-02-15
EP3497117A1 (en) 2019-06-19
US11014967B2 (en) 2021-05-25
CN109963864B (zh) 2024-01-02
DK3497117T3 (da) 2024-04-22
US20190177376A1 (en) 2019-06-13
AU2017311541A1 (en) 2019-02-21
JP2019527715A (ja) 2019-10-03
KR20190038560A (ko) 2019-04-08
US11230576B2 (en) 2022-01-25
AU2017311542A1 (en) 2019-02-07
KR102573370B1 (ko) 2023-09-01
CN109476712A (zh) 2019-03-15
US20250051400A1 (en) 2025-02-13
CN109963864A (zh) 2019-07-02
JP2022160444A (ja) 2022-10-19

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