AU2017272349B2 - Therapeutic recombinant klotho proteins and compositions and methods involving the same - Google Patents
Therapeutic recombinant klotho proteins and compositions and methods involving the same Download PDFInfo
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- AU2017272349B2 AU2017272349B2 AU2017272349A AU2017272349A AU2017272349B2 AU 2017272349 B2 AU2017272349 B2 AU 2017272349B2 AU 2017272349 A AU2017272349 A AU 2017272349A AU 2017272349 A AU2017272349 A AU 2017272349A AU 2017272349 B2 AU2017272349 B2 AU 2017272349B2
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| PCT/US2017/035755 WO2017210607A1 (en) | 2016-06-02 | 2017-06-02 | Therapeutic recombinant klotho proteins and compositions and methods involving the same |
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| AU2017363321B2 (en) * | 2016-11-22 | 2023-09-28 | Klotho Therapeutics, Inc. | Novel recombinant Klotho proteins and compositions and methods involving the same |
| CN108333355B (zh) * | 2018-02-01 | 2020-05-26 | 黄曙 | Klotho蛋白在制备诊断胃肠道间质瘤危险度的试剂中的用途 |
| CN108384747A (zh) * | 2018-03-05 | 2018-08-10 | 安徽省农业科学院园艺研究所 | 表达狂犬抗体的cho细胞无血清悬浮培养方法 |
| CN109251896A (zh) * | 2018-08-13 | 2019-01-22 | 中山大学 | 一株高表达hKLs-his蛋白的细胞株及其制备方法和应用 |
| WO2020160617A1 (en) * | 2019-02-05 | 2020-08-13 | Helium 3 Biotech Pty Ltd | A membrane protein expression and distribution modulating composition and method of use thereof |
| RU2712770C1 (ru) * | 2019-05-21 | 2020-01-31 | Всеволод Викторович Мелехин | Способ ингибирования роста опухолевых клеток |
| IT201900007446A1 (it) | 2019-05-29 | 2020-11-29 | Giuseppe Castellano | Composizione comprendente citrato e carnitina in grado di attivare la produzione della proteina klotho |
| US11891615B2 (en) | 2020-06-10 | 2024-02-06 | Gail Marion Humble | Process to produce Klotho protein in vitro |
| CN112195165A (zh) * | 2020-10-15 | 2021-01-08 | 广东药科大学 | 一种抗衰老分泌型Klotho蛋白及其编码基因、重组表达载体与应用 |
| CN114487218B (zh) * | 2020-10-23 | 2023-11-14 | 北京红惠新医药科技有限公司 | β-烟酰胺单核苷酸的分析方法 |
| CN112915193B (zh) * | 2021-03-05 | 2022-09-13 | 南方医科大学南方医院 | Kp-1在制备治疗慢性肺病的药物中的用途 |
| CN113444730A (zh) * | 2021-03-17 | 2021-09-28 | 昆明市延安医院 | 一种原发性肝细胞klotho基因转导干细胞筛选构建方法 |
| CN113215199A (zh) * | 2021-04-29 | 2021-08-06 | 广州博识生物科技有限公司 | 一种Klotho+/-基因缺失斑马鱼 |
| CN117529331A (zh) * | 2021-05-21 | 2024-02-06 | 巴塞罗那自治大学 | 用于治疗骨病症的Klotho分泌型剪接变体 |
| CN113409306A (zh) * | 2021-07-15 | 2021-09-17 | 推想医疗科技股份有限公司 | 一种检测装置、训练方法、训练装置、设备和介质 |
| WO2023172444A2 (en) * | 2022-03-08 | 2023-09-14 | Mayo Foundation For Medical Education And Research | Senotherapeutic agents and alpha-klotho polypeptides |
| WO2023218445A1 (en) * | 2022-05-08 | 2023-11-16 | Ichilov Tech Ltd. | Klotho derivatives with modified structure |
| WO2024115728A1 (en) * | 2022-12-02 | 2024-06-06 | Universitat Autònoma De Barcelona | Secreted splicing variant of klotho for treating muscle disorders |
Citations (1)
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| WO2000027885A1 (fr) * | 1998-11-05 | 2000-05-18 | Kyowa Hakko Kogyo Co., Ltd. | Nouveau popypeptide chimerique |
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| AU2003303394B2 (en) * | 2002-12-23 | 2009-02-19 | Bristol-Myers Squibb Company | Product quality enhancement in mammalian cell culture processes for protein production |
| TW200936156A (en) * | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
| CN102861343A (zh) * | 2012-10-17 | 2013-01-09 | 南方医科大学 | 分泌型Klotho在制备治疗慢性肾脏病的药物中的应用 |
| WO2015158868A2 (en) * | 2014-04-16 | 2015-10-22 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000027885A1 (fr) * | 1998-11-05 | 2000-05-18 | Kyowa Hakko Kogyo Co., Ltd. | Nouveau popypeptide chimerique |
Non-Patent Citations (2)
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| YAMAZAKI Y ET AL, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 398, no. 3, doi:10.1016/J.BBRC.2010.06.110, ISSN 0006-291X, (2010-07-30), pages 513 - 518, (2010-07-01) * |
| ZHOU, T. B. T. et al., "Biochemical and Functional Characterization of the Klotho-VS Polymorphism Implicated in Aging and Disease Risk", The Journal of Biological Chemistry, 2013, vol. 288, no. 51, pages 36302-36311. * |
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| MX2018014753A (es) | 2019-06-17 |
| KR20190015711A (ko) | 2019-02-14 |
| EP3464608A1 (en) | 2019-04-10 |
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| WO2017210607A1 (en) | 2017-12-07 |
| AU2017272349A1 (en) | 2018-11-22 |
| EP3464608A4 (en) | 2020-01-29 |
| CN116478907A (zh) | 2023-07-25 |
| KR20230125857A (ko) | 2023-08-29 |
| KR102570250B1 (ko) | 2023-08-29 |
| JP2019526272A (ja) | 2019-09-19 |
| CA3025461A1 (en) | 2017-12-07 |
| CN109219663A (zh) | 2019-01-15 |
| MX2023008626A (es) | 2023-08-08 |
| BR112018073909A2 (pt) | 2019-02-26 |
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