AU2017227516B2 - Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine - Google Patents

Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine Download PDF

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Publication number
AU2017227516B2
AU2017227516B2 AU2017227516A AU2017227516A AU2017227516B2 AU 2017227516 B2 AU2017227516 B2 AU 2017227516B2 AU 2017227516 A AU2017227516 A AU 2017227516A AU 2017227516 A AU2017227516 A AU 2017227516A AU 2017227516 B2 AU2017227516 B2 AU 2017227516B2
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AU
Australia
Prior art keywords
troxacitabine
sorafenib
phosphoramidate prodrug
liver
cancer
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AU2017227516A
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English (en)
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AU2017227516A1 (en
Inventor
Mark ALBERTELLA
Anders Eneroth
Björn KLASSON
Fredrik ÖBERG
John ÖHD
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Medivir AB
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Medivir AB
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Publication of AU2017227516A1 publication Critical patent/AU2017227516A1/en
Application granted granted Critical
Publication of AU2017227516B2 publication Critical patent/AU2017227516B2/en
Priority to AU2022203761A priority Critical patent/AU2022203761B2/en
Active legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
AU2017227516A 2016-03-02 2017-02-28 Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine Active AU2017227516B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022203761A AU2022203761B2 (en) 2016-03-02 2022-06-01 Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1650274-2 2016-03-02
SE1650274 2016-03-02
SE1651204 2016-09-08
SE1651204-8 2016-09-08
PCT/SE2017/050186 WO2017151044A1 (en) 2016-03-02 2017-02-28 Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022203761A Division AU2022203761B2 (en) 2016-03-02 2022-06-01 Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine

Publications (2)

Publication Number Publication Date
AU2017227516A1 AU2017227516A1 (en) 2018-08-30
AU2017227516B2 true AU2017227516B2 (en) 2022-03-03

Family

ID=59744330

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017227516A Active AU2017227516B2 (en) 2016-03-02 2017-02-28 Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine
AU2022203761A Active AU2022203761B2 (en) 2016-03-02 2022-06-01 Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022203761A Active AU2022203761B2 (en) 2016-03-02 2022-06-01 Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine

Country Status (17)

Country Link
US (2) US10456413B2 (OSRAM)
EP (1) EP3423061B1 (OSRAM)
JP (1) JP6968080B2 (OSRAM)
KR (1) KR102703122B1 (OSRAM)
CN (2) CN111956646B (OSRAM)
AU (2) AU2017227516B2 (OSRAM)
CA (1) CA3014769C (OSRAM)
ES (1) ES2987989T3 (OSRAM)
HR (1) HRP20241508T1 (OSRAM)
HU (1) HUE068940T2 (OSRAM)
MY (1) MY198140A (OSRAM)
PL (1) PL3423061T3 (OSRAM)
RS (1) RS66090B1 (OSRAM)
RU (1) RU2018134336A (OSRAM)
SG (1) SG11201806855WA (OSRAM)
WO (1) WO2017151044A1 (OSRAM)
ZA (1) ZA201805445B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3423061T3 (pl) 2016-03-02 2024-12-16 Medivir Aktiebolag Leczenie skojarzone sorafenibem lub regorafenibem i amidofosforanowym prolekiem troksacytabiny
JP2021512875A (ja) * 2018-02-02 2021-05-20 カースゲン セラピューティクス カンパニー リミテッドＣａｒｓｇｅｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏ．， Ｌｔｄ． 細胞免疫療法の組み合わせ
JP7337539B2 (ja) 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
CN113453685A (zh) * 2019-02-18 2021-09-28 美迪维尔公司 使用口服给药的二氧戊环核苷酸与抗pd1或抗pdl1单克隆抗体的组合治疗肝癌的方法
US20240024342A1 (en) * 2020-04-15 2024-01-25 Medivir Ab Miv-818/lenvatinib combination therapy for liver cancer
KR20210156389A (ko) 2020-06-17 2021-12-27 재단법인대구경북과학기술원 레고라페닙을 유효성분으로 포함하는 염증질환의 예방 또는 치료용 약학적 조성물
IT202000022636A1 (it) 2020-09-25 2022-03-25 Ente Ospedaliero Specializzato In Gastroenterologia Istituto Nazionale Di Ricovero E Cura A Caratter “terapia di combinazione di sorafenib e/o regorafenib con la proteina ricombinante umana proteoglicano-4 per il trattamento dell'epatocarcinoma”
WO2024205477A1 (en) * 2023-03-30 2024-10-03 Medivir Ab Method for treating liver cancers using fostroxacitabine bralpamide, an immune checkpoint inhibitor and a vegf antagonist

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002030922A2 (en) * 2000-10-13 2002-04-18 Shire Biochem Inc. Dioxolane analogs for improved inter-cellular delivery
WO2005009961A2 (en) * 2003-07-23 2005-02-03 Bayer Pharmaceuticals Corporation Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
WO2016030335A1 (en) * 2014-08-25 2016-03-03 Medivir Ab Dioxolane analogues of uridine for the treatment of cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1158985B1 (en) 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
DE602004011340T2 (de) 2003-05-20 2008-11-06 Bayer Healthcare Llc Diaryl-harnstoffe mit kinasehemmender wirkung
CN102671196B (zh) * 2006-04-05 2014-12-03 诺华股份有限公司 用于治疗癌症的治疗剂的组合
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
CN102190616B (zh) 2010-03-18 2015-07-29 苏州泽璟生物制药有限公司 一种氘代的ω-二苯基脲的合成及生产的方法和工艺
EP4140487A1 (en) 2012-04-13 2023-03-01 Epizyme Inc Combination therapy for treating cancer
CN103570613B (zh) 2012-07-18 2016-06-15 苏州泽璟生物制药有限公司 氘代ω-二苯基脲或其盐的多晶型物
WO2014022116A2 (en) 2012-07-28 2014-02-06 Calitor Sciences, Llc Substituted pyrazolone compounds and methods of use
WO2014047199A1 (en) * 2012-09-19 2014-03-27 The Research Foundation For The State University Of New York Novel prodrugs for selective anticancer therapy
EP3074399A1 (en) * 2013-11-27 2016-10-05 Idenix Pharmaceuticals LLC 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection
BR112016011949A8 (pt) * 2013-11-27 2020-04-28 Idenix Pharmaceuticals Llc composto, composição farmacêutica, e, uso dos mesmos”
PL3423061T3 (pl) * 2016-03-02 2024-12-16 Medivir Aktiebolag Leczenie skojarzone sorafenibem lub regorafenibem i amidofosforanowym prolekiem troksacytabiny

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002030922A2 (en) * 2000-10-13 2002-04-18 Shire Biochem Inc. Dioxolane analogs for improved inter-cellular delivery
WO2005009961A2 (en) * 2003-07-23 2005-02-03 Bayer Pharmaceuticals Corporation Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
WO2016030335A1 (en) * 2014-08-25 2016-03-03 Medivir Ab Dioxolane analogues of uridine for the treatment of cancer

Also Published As

Publication number Publication date
WO2017151044A1 (en) 2017-09-08
AU2017227516A1 (en) 2018-08-30
JP6968080B2 (ja) 2021-11-17
KR102703122B1 (ko) 2024-09-04
CN111956646B (zh) 2023-07-25
US10456413B2 (en) 2019-10-29
CN111956646A (zh) 2020-11-20
JP2019507764A (ja) 2019-03-22
CN109069509B (zh) 2020-10-16
ES2987989T3 (es) 2024-11-18
PL3423061T3 (pl) 2024-12-16
BR112018067387A2 (pt) 2019-01-02
EP3423061A1 (en) 2019-01-09
EP3423061C0 (en) 2024-08-07
AU2022203761B2 (en) 2024-06-13
US20200009166A1 (en) 2020-01-09
RU2018134336A (ru) 2020-04-02
HUE068940T2 (hu) 2025-02-28
US20190091246A1 (en) 2019-03-28
CA3014769C (en) 2024-01-09
EP3423061A4 (en) 2019-11-13
KR20180118745A (ko) 2018-10-31
EP3423061B1 (en) 2024-08-07
AU2022203761A1 (en) 2022-06-16
RS66090B1 (sr) 2024-11-29
ZA201805445B (en) 2019-07-31
RU2018134336A3 (OSRAM) 2020-05-22
CN109069509A (zh) 2018-12-21
MY198140A (en) 2023-08-07
SG11201806855WA (en) 2018-09-27
HRP20241508T1 (hr) 2025-01-03
US10960017B2 (en) 2021-03-30
CA3014769A1 (en) 2017-09-08

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