JP6968080B2 - ソラフェニブ又はレゴラフェニブとトロキサシタビンのホスホロアミデートプロドラッグを用いた併用療法 - Google Patents

ソラフェニブ又はレゴラフェニブとトロキサシタビンのホスホロアミデートプロドラッグを用いた併用療法 Download PDF

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JP6968080B2
JP6968080B2 JP2018545847A JP2018545847A JP6968080B2 JP 6968080 B2 JP6968080 B2 JP 6968080B2 JP 2018545847 A JP2018545847 A JP 2018545847A JP 2018545847 A JP2018545847 A JP 2018545847A JP 6968080 B2 JP6968080 B2 JP 6968080B2
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sorafenib
troxacitabin
cancer
prodrug
liver
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JP2019507764A (ja
JP2019507764A5 (OSRAM
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アルベルテラ，マーク
エネロス，アンデシュ
クラソン，ビョルン
エーベリ，フレドリク
エード，ヨーン
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メディヴィル・アクチエボラーグ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP2018545847A 2016-03-02 2017-02-28 ソラフェニブ又はレゴラフェニブとトロキサシタビンのホスホロアミデートプロドラッグを用いた併用療法 Active JP6968080B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1650274-2 2016-03-02
SE1650274 2016-03-02
SE1651204 2016-09-08
SE1651204-8 2016-09-08
PCT/SE2017/050186 WO2017151044A1 (en) 2016-03-02 2017-02-28 Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine

Publications (3)

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JP2019507764A JP2019507764A (ja) 2019-03-22
JP2019507764A5 JP2019507764A5 (OSRAM) 2020-04-09
JP6968080B2 true JP6968080B2 (ja) 2021-11-17

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JP2018545847A Active JP6968080B2 (ja) 2016-03-02 2017-02-28 ソラフェニブ又はレゴラフェニブとトロキサシタビンのホスホロアミデートプロドラッグを用いた併用療法

Country Status (17)

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US (2) US10456413B2 (OSRAM)
EP (1) EP3423061B1 (OSRAM)
JP (1) JP6968080B2 (OSRAM)
KR (1) KR102703122B1 (OSRAM)
CN (2) CN111956646B (OSRAM)
AU (2) AU2017227516B2 (OSRAM)
CA (1) CA3014769C (OSRAM)
ES (1) ES2987989T3 (OSRAM)
HR (1) HRP20241508T1 (OSRAM)
HU (1) HUE068940T2 (OSRAM)
MY (1) MY198140A (OSRAM)
PL (1) PL3423061T3 (OSRAM)
RS (1) RS66090B1 (OSRAM)
RU (1) RU2018134336A (OSRAM)
SG (1) SG11201806855WA (OSRAM)
WO (1) WO2017151044A1 (OSRAM)
ZA (1) ZA201805445B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3423061T3 (pl) 2016-03-02 2024-12-16 Medivir Aktiebolag Leczenie skojarzone sorafenibem lub regorafenibem i amidofosforanowym prolekiem troksacytabiny
JP2021512875A (ja) * 2018-02-02 2021-05-20 カースゲン セラピューティクス カンパニー リミテッドＣａｒｓｇｅｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏ．， Ｌｔｄ． 細胞免疫療法の組み合わせ
JP7337539B2 (ja) 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
CN113453685A (zh) * 2019-02-18 2021-09-28 美迪维尔公司 使用口服给药的二氧戊环核苷酸与抗pd1或抗pdl1单克隆抗体的组合治疗肝癌的方法
US20240024342A1 (en) * 2020-04-15 2024-01-25 Medivir Ab Miv-818/lenvatinib combination therapy for liver cancer
KR20210156389A (ko) 2020-06-17 2021-12-27 재단법인대구경북과학기술원 레고라페닙을 유효성분으로 포함하는 염증질환의 예방 또는 치료용 약학적 조성물
IT202000022636A1 (it) 2020-09-25 2022-03-25 Ente Ospedaliero Specializzato In Gastroenterologia Istituto Nazionale Di Ricovero E Cura A Caratter “terapia di combinazione di sorafenib e/o regorafenib con la proteina ricombinante umana proteoglicano-4 per il trattamento dell'epatocarcinoma”
WO2024205477A1 (en) * 2023-03-30 2024-10-03 Medivir Ab Method for treating liver cancers using fostroxacitabine bralpamide, an immune checkpoint inhibitor and a vegf antagonist

Family Cites Families (17)

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EP1158985B1 (en) 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2002030922A2 (en) * 2000-10-13 2002-04-18 Shire Biochem Inc. Dioxolane analogs for improved inter-cellular delivery
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
DE602004011340T2 (de) 2003-05-20 2008-11-06 Bayer Healthcare Llc Diaryl-harnstoffe mit kinasehemmender wirkung
NZ544920A (en) * 2003-07-23 2009-11-27 Bayer Healthcare Llc 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
CN102671196B (zh) * 2006-04-05 2014-12-03 诺华股份有限公司 用于治疗癌症的治疗剂的组合
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
CN102190616B (zh) 2010-03-18 2015-07-29 苏州泽璟生物制药有限公司 一种氘代的ω-二苯基脲的合成及生产的方法和工艺
EP4140487A1 (en) 2012-04-13 2023-03-01 Epizyme Inc Combination therapy for treating cancer
CN103570613B (zh) 2012-07-18 2016-06-15 苏州泽璟生物制药有限公司 氘代ω-二苯基脲或其盐的多晶型物
WO2014022116A2 (en) 2012-07-28 2014-02-06 Calitor Sciences, Llc Substituted pyrazolone compounds and methods of use
WO2014047199A1 (en) * 2012-09-19 2014-03-27 The Research Foundation For The State University Of New York Novel prodrugs for selective anticancer therapy
EP3074399A1 (en) * 2013-11-27 2016-10-05 Idenix Pharmaceuticals LLC 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection
BR112016011949A8 (pt) * 2013-11-27 2020-04-28 Idenix Pharmaceuticals Llc composto, composição farmacêutica, e, uso dos mesmos”
SG10201911558UA (en) * 2014-08-25 2020-01-30 Medivir Ab Dioxolane analogues of uridine for the treatment of cancer
PL3423061T3 (pl) * 2016-03-02 2024-12-16 Medivir Aktiebolag Leczenie skojarzone sorafenibem lub regorafenibem i amidofosforanowym prolekiem troksacytabiny

Also Published As

Publication number Publication date
WO2017151044A1 (en) 2017-09-08
AU2017227516A1 (en) 2018-08-30
KR102703122B1 (ko) 2024-09-04
CN111956646B (zh) 2023-07-25
US10456413B2 (en) 2019-10-29
CN111956646A (zh) 2020-11-20
JP2019507764A (ja) 2019-03-22
CN109069509B (zh) 2020-10-16
ES2987989T3 (es) 2024-11-18
PL3423061T3 (pl) 2024-12-16
BR112018067387A2 (pt) 2019-01-02
EP3423061A1 (en) 2019-01-09
EP3423061C0 (en) 2024-08-07
AU2022203761B2 (en) 2024-06-13
US20200009166A1 (en) 2020-01-09
RU2018134336A (ru) 2020-04-02
HUE068940T2 (hu) 2025-02-28
AU2017227516B2 (en) 2022-03-03
US20190091246A1 (en) 2019-03-28
CA3014769C (en) 2024-01-09
EP3423061A4 (en) 2019-11-13
KR20180118745A (ko) 2018-10-31
EP3423061B1 (en) 2024-08-07
AU2022203761A1 (en) 2022-06-16
RS66090B1 (sr) 2024-11-29
ZA201805445B (en) 2019-07-31
RU2018134336A3 (OSRAM) 2020-05-22
CN109069509A (zh) 2018-12-21
MY198140A (en) 2023-08-07
SG11201806855WA (en) 2018-09-27
HRP20241508T1 (hr) 2025-01-03
US10960017B2 (en) 2021-03-30
CA3014769A1 (en) 2017-09-08

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