AU2016370853A1 - Antibodies to quetiapine and use thereof - Google Patents
Antibodies to quetiapine and use thereof Download PDFInfo
- Publication number
- AU2016370853A1 AU2016370853A1 AU2016370853A AU2016370853A AU2016370853A1 AU 2016370853 A1 AU2016370853 A1 AU 2016370853A1 AU 2016370853 A AU2016370853 A AU 2016370853A AU 2016370853 A AU2016370853 A AU 2016370853A AU 2016370853 A1 AU2016370853 A1 AU 2016370853A1
- Authority
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- Australia
- Prior art keywords
- ser
- seq
- leu
- amino acid
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 title claims abstract description 172
- 229960004431 quetiapine Drugs 0.000 title claims abstract description 169
- 239000012634 fragment Substances 0.000 claims abstract description 136
- 230000027455 binding Effects 0.000 claims abstract description 110
- 229960001534 risperidone Drugs 0.000 claims abstract description 66
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims abstract description 66
- 229960005017 olanzapine Drugs 0.000 claims abstract description 61
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims abstract description 61
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims abstract description 59
- 229960004372 aripiprazole Drugs 0.000 claims abstract description 59
- 238000000034 method Methods 0.000 claims abstract description 55
- 238000003556 assay Methods 0.000 claims abstract description 49
- 238000002967 competitive immunoassay Methods 0.000 claims abstract description 16
- 125000000539 amino acid group Chemical group 0.000 claims description 189
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 159
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 132
- 230000009137 competitive binding Effects 0.000 claims description 48
- KRTLKZNAWAMORA-UUCOHRQLSA-N (3s,10s,13r,14r,17r)-17-[(2r)-4-(3,3-dimethyloxiran-2-yl)butan-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCC3=C(CCC4C(C)(C)[C@@H](O)CC[C@@]43C)[C@]2(C)CC1)C)CC1OC1(C)C KRTLKZNAWAMORA-UUCOHRQLSA-N 0.000 claims description 32
- 108091033319 polynucleotide Proteins 0.000 claims description 19
- 102000040430 polynucleotide Human genes 0.000 claims description 19
- 239000002157 polynucleotide Substances 0.000 claims description 19
- 239000003550 marker Substances 0.000 claims description 18
- 239000000164 antipsychotic agent Substances 0.000 claims description 13
- 238000003018 immunoassay Methods 0.000 claims description 12
- 229920001184 polypeptide Polymers 0.000 claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- 238000003149 assay kit Methods 0.000 claims description 11
- PMXMIIMHBWHSKN-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCC(O)C4=NC=3C)=NOC2=C1 PMXMIIMHBWHSKN-UHFFFAOYSA-N 0.000 claims description 10
- 238000002965 ELISA Methods 0.000 claims description 10
- 229960001057 paliperidone Drugs 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 239000002207 metabolite Substances 0.000 claims description 9
- 230000002860 competitive effect Effects 0.000 claims description 8
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 18
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 18
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 15
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 15
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 12
- 108010051242 phenylalanylserine Proteins 0.000 claims 6
- FMDHKPRACUXATF-ACZMJKKPSA-N Ser-Gln-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(O)=O FMDHKPRACUXATF-ACZMJKKPSA-N 0.000 claims 5
- SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical compound NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 claims 4
- XHVONGZZVUUORG-WEDXCCLWSA-N Gly-Thr-Lys Chemical compound NCC(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](C(O)=O)CCCCN XHVONGZZVUUORG-WEDXCCLWSA-N 0.000 claims 4
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- 108010065920 Insulin Lispro Proteins 0.000 claims 3
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- FQZPTCNSNPWHLJ-AVGNSLFASA-N Leu-Gln-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O FQZPTCNSNPWHLJ-AVGNSLFASA-N 0.000 claims 3
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- RMODQFBNDDENCP-IHRRRGAJSA-N Pro-Lys-Leu Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O RMODQFBNDDENCP-IHRRRGAJSA-N 0.000 claims 3
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- SYSWVVCYSXBVJG-RHYQMDGZSA-N Val-Leu-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N)O SYSWVVCYSXBVJG-RHYQMDGZSA-N 0.000 claims 3
- 108010008355 arginyl-glutamine Proteins 0.000 claims 3
- 108010068265 aspartyltyrosine Proteins 0.000 claims 3
- 108010026333 seryl-proline Proteins 0.000 claims 3
- 108010044292 tryptophyltyrosine Proteins 0.000 claims 3
- LGFCAXJBAZESCF-ACZMJKKPSA-N Ala-Gln-Ala Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(O)=O LGFCAXJBAZESCF-ACZMJKKPSA-N 0.000 claims 2
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9466—Antidepressants
Landscapes
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- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| PT2888284T (pt) | 2012-08-21 | 2022-11-18 | Janssen Pharmaceutica Nv | Anticorpos dirigidos contra haptenos de risperidona e a sua utilização |
| PL2888592T3 (pl) | 2012-08-21 | 2018-03-30 | Janssen Pharmaceutica Nv | Przeciwciała względem kwetiapiny i ich zastosowania |
| CA2882595C (en) | 2012-08-21 | 2019-06-04 | Ortho-Clinical Diagnostics, Inc. | Antibodies to olanzapine haptens and use thereof |
| CN104736564B (zh) * | 2012-08-21 | 2019-02-05 | 詹森药业有限公司 | 喹硫平半抗原的抗体及其用途 |
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| JP6994461B2 (ja) | 2015-12-17 | 2022-02-04 | ヤンセン ファーマシューティカ エヌ．ベー． | クエチアピンに対する抗体及びその使用 |
| CN116354904B (zh) * | 2023-04-26 | 2023-08-01 | 北京丹大生物技术有限公司 | 一种喹硫平衍生物半抗原、抗原、抗喹硫平抗体及其应用 |
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2016
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- 2016-12-15 CN CN201680074235.2A patent/CN108368180B/zh not_active Expired - Fee Related
- 2016-12-15 AU AU2016370853A patent/AU2016370853A1/en not_active Abandoned
- 2016-12-15 MA MA044067A patent/MA44067A/fr unknown
- 2016-12-15 US US15/380,729 patent/US10435478B2/en not_active Expired - Fee Related
- 2016-12-15 CA CA3008812A patent/CA3008812A1/en active Pending
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- 2016-12-15 EP EP16826522.1A patent/EP3390455A1/en not_active Withdrawn
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2019
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| WO2017106508A1 (en) | 2017-06-22 |
| US20200002438A1 (en) | 2020-01-02 |
| US11104742B2 (en) | 2021-08-31 |
| JP2019504014A (ja) | 2019-02-14 |
| US20170176474A1 (en) | 2017-06-22 |
| CN108368180A (zh) | 2018-08-03 |
| EP3390455A1 (en) | 2018-10-24 |
| JP6994461B2 (ja) | 2022-02-04 |
| CN108368180B (zh) | 2022-07-26 |
| MA44067A (fr) | 2018-10-24 |
| US10435478B2 (en) | 2019-10-08 |
| CA3008812A1 (en) | 2017-06-22 |
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