AU2016355268B2 - Combination therapy of tetracyclic quinolone analogs for treating cancer - Google Patents

Combination therapy of tetracyclic quinolone analogs for treating cancer Download PDF

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AU2016355268B2
AU2016355268B2 AU2016355268A AU2016355268A AU2016355268B2 AU 2016355268 B2 AU2016355268 B2 AU 2016355268B2 AU 2016355268 A AU2016355268 A AU 2016355268A AU 2016355268 A AU2016355268 A AU 2016355268A AU 2016355268 B2 AU2016355268 B2 AU 2016355268B2
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cancer
compound
optionally substituted
alkyl
pharmaceutically acceptable
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AU2016355268A1 (en
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John Soong
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Senhwa Biosciences Inc
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Senhwa Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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AU2016355268A 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer Active AU2016355268B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021225157A AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2023229524A AU2023229524B2 (en) 2015-11-20 2023-09-13 Combination therapy of tetracyclic quinolone analogs for treating cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562258211P 2015-11-20 2015-11-20
US62/258,211 2015-11-20
PCT/US2016/061176 WO2017087235A1 (en) 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer

Related Child Applications (1)

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AU2021225157A Division AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer

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AU2016355268A1 AU2016355268A1 (en) 2018-06-14
AU2016355268B2 true AU2016355268B2 (en) 2021-08-19

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AU2016355268A Active AU2016355268B2 (en) 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2021225157A Active AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2023229524A Active AU2023229524B2 (en) 2015-11-20 2023-09-13 Combination therapy of tetracyclic quinolone analogs for treating cancer

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AU2021225157A Active AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2023229524A Active AU2023229524B2 (en) 2015-11-20 2023-09-13 Combination therapy of tetracyclic quinolone analogs for treating cancer

Country Status (11)

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US (4) US10857156B2 (OSRAM)
EP (1) EP3377068B1 (OSRAM)
JP (2) JP7017509B2 (OSRAM)
KR (2) KR20250065935A (OSRAM)
CN (2) CN119185322A (OSRAM)
AU (3) AU2016355268B2 (OSRAM)
CA (1) CA3005730A1 (OSRAM)
IL (1) IL259423A (OSRAM)
RU (1) RU2752506C2 (OSRAM)
TW (1) TWI730013B (OSRAM)
WO (1) WO2017087235A1 (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9758518B2 (en) 2015-03-04 2017-09-12 Pimera, Inc. Compositions, uses and methods for making them
US10857156B2 (en) 2015-11-20 2020-12-08 Senhwa Biosciences, Inc. Combination therapy of tetracyclic quinolone analogs for treating cancer
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
AU2017330390A1 (en) * 2016-09-23 2019-04-18 The Johns Hopkins University Combinatory treatment strategies of cancer based on RNA polymerase I inhibition
EP3601286A4 (en) 2017-03-28 2020-09-23 Pimera, Inc. NEW CRYSTALLINE FORMS OF A POL1 INHIBITOR
US11130740B2 (en) 2017-04-25 2021-09-28 Arbutus Biopharma Corporation Substituted 2,3-dihydro-1H-indene analogs and methods using same
US20210030735A1 (en) * 2018-02-05 2021-02-04 Tesaro, Inc. Pediatric niraparib formulations and pediatric treatment methods
KR20200131251A (ko) * 2018-02-15 2020-11-23 센화 바이오사이언시즈 인코포레이티드 퀴놀론 유사체 및 이의 염, 조성물, 및 이들의 사용 방법
WO2019177011A1 (ja) * 2018-03-13 2019-09-19 国立大学法人大阪大学 腫瘍免疫賦活剤
US12083118B2 (en) 2018-03-29 2024-09-10 Arbutus Biopharma Corporation Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same
GB201816825D0 (en) * 2018-10-16 2018-11-28 Phoremost Ltd Target for anti-cancer therapy
US20230158071A1 (en) * 2018-12-07 2023-05-25 Crage Medical Co., Limited Tumor combined immunotherapy
CN113453685A (zh) 2019-02-18 2021-09-28 美迪维尔公司 使用口服给药的二氧戊环核苷酸与抗pd1或抗pdl1单克隆抗体的组合治疗肝癌的方法
CN110075061A (zh) * 2019-03-13 2019-08-02 安庆瑄宇医药科技有限公司 一种尼拉帕尼口服液及其制备方法
CN114599368A (zh) * 2019-08-14 2022-06-07 生华生物科技股份有限公司 四环化合物及其盐、组合物以及其使用方法
IL294399A (en) * 2020-01-09 2022-08-01 Astrazeneca Ab Combination therapy for treating cancer
CN113491768A (zh) * 2020-04-01 2021-10-12 深圳市罗湖区人民医院 Cd137抗体在制备促进nk细胞表达cd16分子的药物中的应用
WO2022036067A1 (en) * 2020-08-12 2022-02-17 Servier Pharmaceuticals, Llc Combination therapies for use in treating cancer
CN114409681A (zh) * 2022-03-18 2022-04-29 信义核新(北京)生物科技有限公司 用于治疗dna损伤修复缺陷肿瘤的喹诺酮类似物及其应用
CN115160341B (zh) * 2022-07-18 2023-07-18 中国医学科学院医学实验动物研究所 苯并噁嗪类化合物及其药物用途
CN119768184A (zh) * 2022-08-30 2025-04-04 东丽株式会社 用于癌的治疗和/或预防的药品
CN116063328B (zh) * 2023-03-29 2023-06-20 信义核新(北京)生物科技有限公司 一种四环喹诺酮化合物、药学上可接受的盐及其应用
WO2024222630A1 (zh) * 2023-04-23 2024-10-31 信义核新(北京)生物科技有限公司 喹诺酮衍生物及其在抗肿瘤中的应用
WO2024242545A1 (ko) * 2023-05-23 2024-11-28 (주) 메티메디제약 칼슘 락테이트를 활성 성분으로 포함하는 암 백신 조성물 및 그 용도
WO2025101688A1 (en) * 2023-11-08 2025-05-15 Mary Hitchcock Memorial Hospital For Itself And On Behalf Of Dartmouth-Hitchcock Clinic (Collectively Doing Business As Dartmouth-Hitchcock) Combination therapy using tetrathiomolybdate

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009127414A2 (en) * 2008-04-16 2009-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inhibition of angiogenesis and tumor metastasis
US20110218184A1 (en) * 2007-10-05 2011-09-08 Cylene Pharmaceuticals, Inc. Quinolone analogs and methods related thereto
US20130274198A1 (en) * 2012-03-28 2013-10-17 Dana-Farber Cancer Institute, Inc. Treating muc1-expressing cancers with combination therapies
US20140113951A1 (en) * 2011-03-11 2014-04-24 Sarissa Inc. Method of Treating Cancer by Inhibition of DNA Repair Proteins
US20140364434A1 (en) * 2011-12-07 2014-12-11 The Regents Of The University Of California Biomarkers for Prediction of Response to PARP Inhibition in Breast Cancer
WO2014209804A1 (en) * 2013-06-24 2014-12-31 Biomed Valley Discoveries, Inc. Bispecific antibodies

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
ATE269848T1 (de) 1999-04-07 2004-07-15 Univ Virginia Calciumkanalblocker als antikrebsmittel
AU2002361493A1 (en) 2001-12-13 2003-06-23 Wockhardt Limited New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6900224B2 (en) 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
EP1633724B1 (en) 2003-03-12 2011-05-04 Kudos Pharmaceuticals Limited Phthalazinone derivatives
BRPI0412899B1 (pt) 2003-07-25 2021-10-05 Cancer Research Technology Limited Uso de um composto ou um sal farmaceuticamente aceitável do mesmo para a manufatura de um medicamento citotóxico para o tratamento de câncer de ovário, câncer de mama, câncer de próstata ou câncer pancreático
KR101137311B1 (ko) 2003-09-22 2012-04-23 얀센 파마슈티카 엔.브이. 7-아미노알킬리데닐-헤테로사이클릭 퀴놀론 및 나프티리돈
EP1684736B1 (en) 2003-12-01 2011-08-24 Kudos Pharmaceuticals Limited Dna damage repair inhibitors for treatment of cancer
ES2873875T3 (es) 2004-05-13 2021-11-04 Icos Corp Quinazolinonas como inhibidores de fosfatidilinositol 3-quinasa delta humano
MX2007003282A (es) 2004-09-17 2007-10-16 Cylene Pharmaceuticals Inc Analogos de quinolona.
DK1928887T3 (en) 2005-08-05 2015-03-23 Senhwa Biosciences Inc Methods for preparing quinolonanaloger
WO2007022474A2 (en) 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF
AR057555A1 (es) 2005-10-27 2007-12-05 Merck Frosst Canada Ltd Un inhibidor de fosfodiesterasa-4 4-oxo-1-(3-sustituido fenil-1,4-dihidro-1,8-naftiridin-3-carboxamida y un procedimiento de preparacion del mismo
US20090291437A1 (en) 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
US20100063046A1 (en) 2006-05-17 2010-03-11 Whitten Jeffrey P Tetracyclic imidazole analogs
WO2007146813A2 (en) 2006-06-08 2007-12-21 Cylene Pharmaceuticals, Inc. Pyridinone analogs as cell proliferation inhibitors
US20100305136A1 (en) 2006-06-08 2010-12-02 Johnny Yasuo Nagasawa Quinolone analogs derivatized with sulfonic acid, sulfonate or sulfonamide
GB0701992D0 (en) 2007-02-02 2007-03-14 7Tm Pharma As Grehlin Receptor Modulators
US20110065687A1 (en) 2007-04-17 2011-03-17 Michael Schwaebe Hydrazide compounds and uses thereof
US20100112089A1 (en) 2008-05-14 2010-05-06 Takeda Pharmaceutical Company Limited Peptide compound and use thereof
US20140086839A1 (en) 2011-03-17 2014-03-27 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
WO2013082366A1 (en) * 2011-12-01 2013-06-06 The Brigham And Women's Hospital, Inc. Anti-ceacam1 recombinant antibodies for cancer therapy
CA2873402C (en) * 2012-05-15 2023-10-24 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
US9415118B2 (en) 2013-03-13 2016-08-16 Novartis Ag Antibody drug conjugates
ES2754207T3 (es) 2013-11-28 2020-04-16 Tel Hashomer Medical Res Infrastructure & Services Ltd Inhibidores de la ARN polimerasa I y usos de los mismos
SI3134123T1 (sl) 2014-02-21 2021-08-31 Nektar Therapeutics (India) Pvt. Ltd. IL-2Rbeta-selektivni agonisti v kombinaciji s protitelesom proti- CTLA-4 ali protitelesom proti-PD-1
US10857156B2 (en) 2015-11-20 2020-12-08 Senhwa Biosciences, Inc. Combination therapy of tetracyclic quinolone analogs for treating cancer
US9957282B2 (en) 2015-12-14 2018-05-01 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
KR20200131251A (ko) 2018-02-15 2020-11-23 센화 바이오사이언시즈 인코포레이티드 퀴놀론 유사체 및 이의 염, 조성물, 및 이들의 사용 방법
TW202115091A (zh) 2019-08-14 2021-04-16 生華生物科技股份有限公司 喹啉類似物之結晶型及其鹽類、組合物、及彼等之使用方法
CN114599368A (zh) 2019-08-14 2022-06-07 生华生物科技股份有限公司 四环化合物及其盐、组合物以及其使用方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110218184A1 (en) * 2007-10-05 2011-09-08 Cylene Pharmaceuticals, Inc. Quinolone analogs and methods related thereto
WO2009127414A2 (en) * 2008-04-16 2009-10-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inhibition of angiogenesis and tumor metastasis
US20140113951A1 (en) * 2011-03-11 2014-04-24 Sarissa Inc. Method of Treating Cancer by Inhibition of DNA Repair Proteins
US20140364434A1 (en) * 2011-12-07 2014-12-11 The Regents Of The University Of California Biomarkers for Prediction of Response to PARP Inhibition in Breast Cancer
US20130274198A1 (en) * 2012-03-28 2013-10-17 Dana-Farber Cancer Institute, Inc. Treating muc1-expressing cancers with combination therapies
WO2014209804A1 (en) * 2013-06-24 2014-12-31 Biomed Valley Discoveries, Inc. Bispecific antibodies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SANDEEP S. NEGI ET AL, "rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis", ONCOTARGET, (2015-07-20), vol. 6, no. 20, doi:10.18632/oncotarget.4093 *
SANDEEP S. NEGI ET AL, "Transient rRNA synthesis inhibition with CX-5461 is sufficient to elicit growth arrest and cell death in acute lymphoblastic leukemia cells", ONCOTARGET, (2015-10-27), vol. 6, no. 33, doi:10.18632/oncotarget.5413 *

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