AU2016353350B2 - Formulation of L-ornithine phenylacetate - Google Patents
Formulation of L-ornithine phenylacetate Download PDFInfo
- Publication number
- AU2016353350B2 AU2016353350B2 AU2016353350A AU2016353350A AU2016353350B2 AU 2016353350 B2 AU2016353350 B2 AU 2016353350B2 AU 2016353350 A AU2016353350 A AU 2016353350A AU 2016353350 A AU2016353350 A AU 2016353350A AU 2016353350 B2 AU2016353350 B2 AU 2016353350B2
- Authority
- AU
- Australia
- Prior art keywords
- phenylacetylglutamine
- plasma
- phenylacetate
- pharmaceutical formulation
- auco
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 title claims abstract description 75
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- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 198
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims description 87
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Priority Applications (1)
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AU2021290236A AU2021290236A1 (en) | 2015-11-13 | 2021-12-21 | Formulations of L-ornithine phenylacetate |
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US201562255300P | 2015-11-13 | 2015-11-13 | |
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US15/133,087 | 2016-04-19 | ||
US15/133,087 US20160338982A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
PCT/US2016/061678 WO2017083758A1 (en) | 2015-11-13 | 2016-11-11 | Formulation of l-ornithine phenylacetate |
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AU2021290236A Division AU2021290236A1 (en) | 2015-11-13 | 2021-12-21 | Formulations of L-ornithine phenylacetate |
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AU2016353350A1 AU2016353350A1 (en) | 2018-05-10 |
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AU2021290236A Abandoned AU2021290236A1 (en) | 2015-11-13 | 2021-12-21 | Formulations of L-ornithine phenylacetate |
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EP (1) | EP3373923A4 (ja) |
JP (2) | JP7294807B2 (ja) |
KR (1) | KR20180086431A (ja) |
CN (2) | CN113768863A (ja) |
AU (2) | AU2016353350B2 (ja) |
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CU20200012A7 (es) | 2017-08-14 | 2021-02-04 | Axcella Health Inc | Composiciones de aminoácidos para el tratamiento de enfermedad hepática |
CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
CA3157376A1 (en) * | 2019-10-16 | 2021-04-22 | Ocera Therapeutics, Inc. | Dosages and uses of ornithine phenylacetate for treating hyperammonemia |
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WO2006056794A1 (en) * | 2004-11-26 | 2006-06-01 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
WO2010144498A2 (en) * | 2009-06-08 | 2010-12-16 | Ucl Business Plc | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
US8173706B2 (en) * | 2009-04-03 | 2012-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
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US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
GB0426141D0 (en) * | 2004-11-26 | 2004-12-29 | Ucl Biomedica Plc | Treatment |
DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
AU2015221466B2 (en) | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
AU2014250643B2 (en) | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
TR201903978T4 (tr) | 2010-10-06 | 2019-04-22 | Ocera Therapeutics Inc | L-ornitin fenil asetat yapım yöntemleri. |
CN103705490B (zh) * | 2013-10-31 | 2016-08-17 | 蚌埠丰原医药科技发展有限公司 | 一种门冬氨酸鸟氨酸的缓释制剂及其制备工艺 |
CN107708684A (zh) * | 2015-04-20 | 2018-02-16 | 欧塞拉治疗有限公司 | L‑鸟氨酸苯乙酸盐制剂 |
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WO2006056794A1 (en) * | 2004-11-26 | 2006-06-01 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
US8173706B2 (en) * | 2009-04-03 | 2012-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
WO2010144498A2 (en) * | 2009-06-08 | 2010-12-16 | Ucl Business Plc | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
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EP3373923A4 (en) | 2019-07-03 |
MX2018005088A (es) | 2019-05-16 |
CA3004331A1 (en) | 2017-05-18 |
WO2017083758A1 (en) | 2017-05-18 |
RU2018113801A (ru) | 2019-12-16 |
AU2016353350A1 (en) | 2018-05-10 |
SG11201802987UA (en) | 2018-05-30 |
EP3373923A1 (en) | 2018-09-19 |
MX2022001517A (es) | 2022-11-16 |
IL258630B1 (en) | 2023-04-01 |
BR112018009349A2 (pt) | 2018-11-13 |
JP2022058446A (ja) | 2022-04-12 |
CN108366983A (zh) | 2018-08-03 |
JP7294807B2 (ja) | 2023-06-20 |
KR20180086431A (ko) | 2018-07-31 |
IL258630B2 (en) | 2023-08-01 |
CN113768863A (zh) | 2021-12-10 |
AU2021290236A1 (en) | 2022-02-10 |
BR112018009349A8 (pt) | 2019-02-26 |
IL258630A (en) | 2018-06-28 |
JP2018533601A (ja) | 2018-11-15 |
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