AU2016246524B2 - Pharmaceutical compositions for combination therapy - Google Patents

Pharmaceutical compositions for combination therapy Download PDF

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Publication number
AU2016246524B2
AU2016246524B2 AU2016246524A AU2016246524A AU2016246524B2 AU 2016246524 B2 AU2016246524 B2 AU 2016246524B2 AU 2016246524 A AU2016246524 A AU 2016246524A AU 2016246524 A AU2016246524 A AU 2016246524A AU 2016246524 B2 AU2016246524 B2 AU 2016246524B2
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AU
Australia
Prior art keywords
insulin
pharmaceutical composition
liver
disease
oca
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016246524A
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English (en)
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AU2016246524A1 (en
Inventor
Luciano Adorini
Mark Pruzanski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intercept Pharmaceuticals Inc
Original Assignee
Intercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
Publication of AU2016246524A1 publication Critical patent/AU2016246524A1/en
Application granted granted Critical
Publication of AU2016246524B2 publication Critical patent/AU2016246524B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016246524A 2015-04-07 2016-04-06 Pharmaceutical compositions for combination therapy Ceased AU2016246524B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562144040P 2015-04-07 2015-04-07
US62/144,040 2015-04-07
PCT/US2016/026146 WO2016164413A1 (en) 2015-04-07 2016-04-06 Pharmaceutical compositions for combination therapy

Publications (2)

Publication Number Publication Date
AU2016246524A1 AU2016246524A1 (en) 2017-10-26
AU2016246524B2 true AU2016246524B2 (en) 2021-04-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016246524A Ceased AU2016246524B2 (en) 2015-04-07 2016-04-06 Pharmaceutical compositions for combination therapy

Country Status (25)

Country Link
US (1) US10894054B2 (cg-RX-API-DMAC10.html)
EP (1) EP3280421B1 (cg-RX-API-DMAC10.html)
JP (1) JP6879931B2 (cg-RX-API-DMAC10.html)
KR (1) KR20170132879A (cg-RX-API-DMAC10.html)
CN (1) CN107613986A (cg-RX-API-DMAC10.html)
AR (1) AR104195A1 (cg-RX-API-DMAC10.html)
AU (1) AU2016246524B2 (cg-RX-API-DMAC10.html)
BR (1) BR112017021311A2 (cg-RX-API-DMAC10.html)
CA (1) CA2981507A1 (cg-RX-API-DMAC10.html)
CL (2) CL2017002538A1 (cg-RX-API-DMAC10.html)
CO (1) CO2017010292A2 (cg-RX-API-DMAC10.html)
CR (1) CR20170456A (cg-RX-API-DMAC10.html)
EA (1) EA036757B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP17073004A (cg-RX-API-DMAC10.html)
ES (1) ES2974281T3 (cg-RX-API-DMAC10.html)
IL (2) IL254772A0 (cg-RX-API-DMAC10.html)
MA (1) MA41083A1 (cg-RX-API-DMAC10.html)
MX (1) MX2017012893A (cg-RX-API-DMAC10.html)
NI (1) NI201700121A (cg-RX-API-DMAC10.html)
PE (1) PE20180034A1 (cg-RX-API-DMAC10.html)
SM (1) SMT202400104T1 (cg-RX-API-DMAC10.html)
SV (1) SV2017005539A (cg-RX-API-DMAC10.html)
TN (1) TN2017000426A1 (cg-RX-API-DMAC10.html)
TW (1) TW201642869A (cg-RX-API-DMAC10.html)
WO (1) WO2016164413A1 (cg-RX-API-DMAC10.html)

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BR112017021311A2 (pt) 2018-06-26
EA036757B1 (ru) 2020-12-17
AR104195A1 (es) 2017-07-05
NI201700121A (es) 2018-01-10
SV2017005539A (es) 2019-01-18
MX2017012893A (es) 2018-01-15
PE20180034A1 (es) 2018-01-09
ES2974281T3 (es) 2024-06-26
CL2018001007A1 (es) 2018-06-15
IL268316A (en) 2019-09-26
SMT202400104T1 (it) 2024-05-14
EP3280421A4 (en) 2019-08-28
CO2017010292A2 (es) 2018-01-05
IL254772A0 (en) 2017-12-31
US20180117065A1 (en) 2018-05-03
JP2018510900A (ja) 2018-04-19
KR20170132879A (ko) 2017-12-04
CL2017002538A1 (es) 2018-04-20
EA201792203A1 (ru) 2018-02-28
US10894054B2 (en) 2021-01-19
ECSP17073004A (es) 2018-02-28
WO2016164413A1 (en) 2016-10-13
AU2016246524A1 (en) 2017-10-26
TW201642869A (zh) 2016-12-16
IL268316B (en) 2022-02-01
JP6879931B2 (ja) 2021-06-02
CA2981507A1 (en) 2016-10-13
MA41083A1 (fr) 2018-05-31
EP3280421B1 (en) 2023-12-27
CN107613986A (zh) 2018-01-19
CR20170456A (es) 2018-06-13
EP3280421A1 (en) 2018-02-14
TN2017000426A1 (en) 2019-04-12

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