AU2015356643B2 - Methods and compositions using Klotho variant polypeptides - Google Patents

Methods and compositions using Klotho variant polypeptides Download PDF

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Publication number
AU2015356643B2
AU2015356643B2 AU2015356643A AU2015356643A AU2015356643B2 AU 2015356643 B2 AU2015356643 B2 AU 2015356643B2 AU 2015356643 A AU2015356643 A AU 2015356643A AU 2015356643 A AU2015356643 A AU 2015356643A AU 2015356643 B2 AU2015356643 B2 AU 2015356643B2
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klotho
seq
polypeptide
fgf23
fusion
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AU2015356643A1 (en
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Donglin Guo
Chikwendu Ibebunjo
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01031—Beta-glucuronidase (3.2.1.31)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Biophysics (AREA)
  • Hematology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
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  • Rheumatology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
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AU2015356643A 2014-12-04 2015-12-02 Methods and compositions using Klotho variant polypeptides Ceased AU2015356643B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462087516P 2014-12-04 2014-12-04
US62/087,516 2014-12-04
PCT/IB2015/059294 WO2016088059A1 (en) 2014-12-04 2015-12-02 Methods and compositions using klotho variant polypeptides

Publications (2)

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AU2015356643A1 AU2015356643A1 (en) 2017-06-22
AU2015356643B2 true AU2015356643B2 (en) 2019-01-24

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US (2) US10654909B2 (cg-RX-API-DMAC7.html)
EP (1) EP3227319B1 (cg-RX-API-DMAC7.html)
JP (1) JP2017537926A (cg-RX-API-DMAC7.html)
KR (1) KR20170084332A (cg-RX-API-DMAC7.html)
CN (1) CN107810201A (cg-RX-API-DMAC7.html)
AU (1) AU2015356643B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017011398A2 (cg-RX-API-DMAC7.html)
CA (1) CA2969307A1 (cg-RX-API-DMAC7.html)
EA (1) EA201791238A1 (cg-RX-API-DMAC7.html)
MX (2) MX2017007303A (cg-RX-API-DMAC7.html)
TW (1) TW201628641A (cg-RX-API-DMAC7.html)
WO (1) WO2016088059A1 (cg-RX-API-DMAC7.html)

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JP7244923B2 (ja) * 2016-11-22 2023-03-23 クロトー セラピューティクス インコーポレイテッド 新規な組換えクロトータンパク質ならびにそれを含む組成物
JP7316946B2 (ja) 2017-07-06 2023-07-28 イエール ユニバーシティ 内分泌型ｆｇｆ関連疾患を処置または防止するための組成物および方法
EP3724230A4 (en) * 2017-12-13 2022-01-19 Yale University Compositions and methods for treating or preventing endocrine fgf23-linked diseases
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US20220008520A1 (en) * 2018-11-21 2022-01-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for reducing age-related striated muscle and cognitive decline
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