JP2017537926A - Ｋｌｏｔｈｏ変種ポリペプチドを使用する方法および組成物 - Google Patents

Ｋｌｏｔｈｏ変種ポリペプチドを使用する方法および組成物 Download PDF

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JP2017537926A
JP2017537926A JP2017529778A JP2017529778A JP2017537926A JP 2017537926 A JP2017537926 A JP 2017537926A JP 2017529778 A JP2017529778 A JP 2017529778A JP 2017529778 A JP2017529778 A JP 2017529778A JP 2017537926 A JP2017537926 A JP 2017537926A
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klotho
seq
fgf23
sklotho
fusion
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JP2017537926A5 (cg-RX-API-DMAC7.html
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グオ，ドンリン
イベブンジョ，チクウェンデュ
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ノバルティス アーゲー
ノバルティス アーゲー
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/475—Growth factors; Growth regulators
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JP2017529778A 2014-12-04 2015-12-02 Ｋｌｏｔｈｏ変種ポリペプチドを使用する方法および組成物 Pending JP2017537926A (ja)

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US201462087516P 2014-12-04 2014-12-04
US62/087,516 2014-12-04
PCT/IB2015/059294 WO2016088059A1 (en) 2014-12-04 2015-12-02 Methods and compositions using klotho variant polypeptides

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JP2017537926A true JP2017537926A (ja) 2017-12-21
JP2017537926A5 JP2017537926A5 (cg-RX-API-DMAC7.html) 2019-01-17

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US (2) US10654909B2 (cg-RX-API-DMAC7.html)
EP (1) EP3227319B1 (cg-RX-API-DMAC7.html)
JP (1) JP2017537926A (cg-RX-API-DMAC7.html)
KR (1) KR20170084332A (cg-RX-API-DMAC7.html)
CN (1) CN107810201A (cg-RX-API-DMAC7.html)
AU (1) AU2015356643B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017011398A2 (cg-RX-API-DMAC7.html)
CA (1) CA2969307A1 (cg-RX-API-DMAC7.html)
EA (1) EA201791238A1 (cg-RX-API-DMAC7.html)
MX (2) MX2017007303A (cg-RX-API-DMAC7.html)
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US10632180B2 (en) 2015-02-06 2020-04-28 The Regents Of The University Of California Methods and compositions for improved cognition
JP7244923B2 (ja) * 2016-11-22 2023-03-23 クロトー セラピューティクス インコーポレイテッド 新規な組換えクロトータンパク質ならびにそれを含む組成物
JP7316946B2 (ja) 2017-07-06 2023-07-28 イエール ユニバーシティ 内分泌型ｆｇｆ関連疾患を処置または防止するための組成物および方法
EP3724230A4 (en) * 2017-12-13 2022-01-19 Yale University Compositions and methods for treating or preventing endocrine fgf23-linked diseases
WO2019140250A1 (en) * 2018-01-12 2019-07-18 New York University SOLUBLE α-KLOTH PROTEINS, PROTEIN FRAGMENTS, AND USES THEREOF
US20220008520A1 (en) * 2018-11-21 2022-01-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for reducing age-related striated muscle and cognitive decline
CN112695049A (zh) * 2020-08-20 2021-04-23 山东兴瑞生物科技有限公司 修饰间充质干细胞的融合基因、质粒、修饰得到干细胞及制备方法
CN112915193B (zh) * 2021-03-05 2022-09-13 南方医科大学南方医院 Kp-1在制备治疗慢性肺病的药物中的用途
CN112915192B (zh) * 2021-03-05 2022-10-25 南方医科大学南方医院 Kp-1在制备治疗慢性肝病的药物中的用途
WO2023035014A2 (en) * 2021-09-03 2023-03-09 The Uab Research Foundation Uab Osp Fibroblast growth factor 23 modulating compounds
WO2024168241A2 (en) * 2023-02-10 2024-08-15 The Trustees Of Indiana University Stabilized fgf23 fusion proteins, compositions and a targeted therapy for hyperphosphatemia
EP4434534A1 (en) 2023-03-22 2024-09-25 ADvantage Therapeutics, Inc. Klotho mrna
US20250154487A1 (en) * 2023-11-10 2025-05-15 Regeneron Pharmaceuticals, Inc. Engineered alpha klotho polypeptides and uses thereof
US20250376667A1 (en) * 2024-06-07 2025-12-11 Regeneron Pharmaceuticals, Inc. Engineered alpha klotho polypeptides and uses thereof

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