AU2015316611B2 - Imidazo[4,5-c]pyridine derived SSAO inhibitors - Google Patents

Imidazo[4,5-c]pyridine derived SSAO inhibitors Download PDF

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Publication number
AU2015316611B2
AU2015316611B2 AU2015316611A AU2015316611A AU2015316611B2 AU 2015316611 B2 AU2015316611 B2 AU 2015316611B2 AU 2015316611 A AU2015316611 A AU 2015316611A AU 2015316611 A AU2015316611 A AU 2015316611A AU 2015316611 B2 AU2015316611 B2 AU 2015316611B2
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cyano
optionally substituted
ring
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AU2015316611A1 (en
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Lee Patient
Edward Savory
Iain Simpson
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Proximagen LLC
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Proximagen LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
AU2015316611A 2014-09-17 2015-09-17 Imidazo[4,5-c]pyridine derived SSAO inhibitors Ceased AU2015316611B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1416444.6A GB201416444D0 (en) 2014-09-17 2014-09-17 New compounds
GB1416444.6 2014-09-17
PCT/GB2015/052691 WO2016042332A1 (en) 2014-09-17 2015-09-17 Imidazo[4,5-c]pyridine derived ssao inhibitors

Publications (2)

Publication Number Publication Date
AU2015316611A1 AU2015316611A1 (en) 2017-04-06
AU2015316611B2 true AU2015316611B2 (en) 2019-05-30

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AU2015316611A Ceased AU2015316611B2 (en) 2014-09-17 2015-09-17 Imidazo[4,5-c]pyridine derived SSAO inhibitors

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US (1) US11530208B2 (OSRAM)
EP (1) EP3194389B1 (OSRAM)
JP (1) JP6589246B2 (OSRAM)
CN (1) CN107074853B (OSRAM)
AU (1) AU2015316611B2 (OSRAM)
BR (1) BR112017005324A2 (OSRAM)
CA (1) CA2961424A1 (OSRAM)
DK (1) DK3194389T3 (OSRAM)
ES (1) ES2744548T3 (OSRAM)
GB (1) GB201416444D0 (OSRAM)
HU (1) HUE045827T2 (OSRAM)
IL (1) IL251166B (OSRAM)
PL (1) PL3194389T3 (OSRAM)
PT (1) PT3194389T (OSRAM)
WO (1) WO2016042332A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201304526D0 (en) * 2013-03-13 2013-04-24 Proximagen Ltd New compounds
GB201416446D0 (en) * 2014-09-17 2014-10-29 Proximagen Ltd New enzyme inhibitor compounds
WO2018027892A1 (en) 2016-08-12 2018-02-15 Eli Lilly And Company Amino pyrimidine ssao inhibitors
WO2018148856A1 (en) 2017-02-14 2018-08-23 Eli Lilly And Company Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors
WO2022046779A1 (en) 2020-08-25 2022-03-03 Eli Lilly And Company Polymorphs of an ssao inhibitor

Citations (5)

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Publication number Priority date Publication date Assignee Title
WO2002038153A1 (en) * 2000-11-09 2002-05-16 Biovitrum Ab New use of 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine derivatives
WO2010031791A1 (en) * 2008-09-16 2010-03-25 Biovitrum Ab (Publ) New compounds ii
WO2010031789A1 (en) * 2008-09-16 2010-03-25 Biovitrum Ab (Publ) New compounds i
WO2014140592A1 (en) * 2013-03-13 2014-09-18 Proximagen Limited Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as ssao inhibitors
US20150258101A1 (en) * 2014-03-13 2015-09-17 Proximagen Limited New compounds

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US6982286B2 (en) 2001-07-12 2006-01-03 Biotie Therapies Corp. Carbocyclic hydrazino inhibitors of copper-containing amine oxidases
US20050096360A1 (en) 2003-08-08 2005-05-05 Salter-Cid Luisa M. Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment of diseases
JP2007504238A (ja) 2003-09-04 2007-03-01 アベンティス・ファーマスーティカルズ・インコーポレイテツド ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）の阻害剤としての置換インドール
WO2007120528A2 (en) 2006-03-31 2007-10-25 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
US7947723B2 (en) 2008-02-01 2011-05-24 Spelman College Synthesis and anti-proliferative effect of benzimidazole derivatives
DK2376490T3 (da) 2008-12-04 2013-04-15 Proximagen Ltd Imidazopyridinforbindelser
EP2417133A1 (en) 2009-04-06 2012-02-15 PTC Therapeutics, Inc. Compounds and methods for antiviral treatment
GB201004311D0 (en) * 2010-03-15 2010-04-28 Proximagen Ltd New enzyme inhibitor compounds
EP2518071A1 (en) * 2011-04-29 2012-10-31 Almirall, S.A. Imidazopyridine derivatives as PI3K inhibitors
US9150574B2 (en) 2011-09-14 2015-10-06 Proximagen Limited Enzyme inhibitor compounds
GB201115853D0 (en) 2011-09-14 2011-10-26 Proximagen Ltd New enzyme inhibitor compounds
WO2013078254A1 (en) 2011-11-22 2013-05-30 Array Biopharma Inc. Bicyclic heteroaryl derivatives as kinase inhibitors
GB201304527D0 (en) 2013-03-13 2013-04-24 Proximagen Ltd New compounds
WO2015189534A1 (en) 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
GB201416446D0 (en) 2014-09-17 2014-10-29 Proximagen Ltd New enzyme inhibitor compounds
CA3007768A1 (en) * 2015-12-07 2017-06-15 Benevolentai Cambridge Limited Vap-1 inhibitors for treating pain
GB201709136D0 (en) * 2017-06-08 2017-07-26 Proximagen Ltd New therapeutic uses of enzyme inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038153A1 (en) * 2000-11-09 2002-05-16 Biovitrum Ab New use of 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine derivatives
WO2010031791A1 (en) * 2008-09-16 2010-03-25 Biovitrum Ab (Publ) New compounds ii
WO2010031789A1 (en) * 2008-09-16 2010-03-25 Biovitrum Ab (Publ) New compounds i
WO2014140592A1 (en) * 2013-03-13 2014-09-18 Proximagen Limited Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as ssao inhibitors
US20150258101A1 (en) * 2014-03-13 2015-09-17 Proximagen Limited New compounds

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Publication number Publication date
JP6589246B2 (ja) 2019-10-16
AU2015316611A1 (en) 2017-04-06
GB201416444D0 (en) 2014-10-29
BR112017005324A2 (pt) 2017-12-12
US11530208B2 (en) 2022-12-20
ES2744548T3 (es) 2020-02-25
DK3194389T3 (da) 2019-09-09
US20170275281A1 (en) 2017-09-28
JP2017532315A (ja) 2017-11-02
EP3194389A1 (en) 2017-07-26
CA2961424A1 (en) 2016-03-24
IL251166B (en) 2020-06-30
PT3194389T (pt) 2019-09-19
HUE045827T2 (hu) 2020-01-28
WO2016042332A1 (en) 2016-03-24
PL3194389T3 (pl) 2019-11-29
CN107074853B (zh) 2019-07-23
IL251166A0 (en) 2017-04-30
EP3194389B1 (en) 2019-08-07
CN107074853A (zh) 2017-08-18

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