AU2015296304B2 - Methods, compositions, and kits for analysis of structurally diverse complex lipids - Google Patents

Methods, compositions, and kits for analysis of structurally diverse complex lipids Download PDF

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Publication number
AU2015296304B2
AU2015296304B2 AU2015296304A AU2015296304A AU2015296304B2 AU 2015296304 B2 AU2015296304 B2 AU 2015296304B2 AU 2015296304 A AU2015296304 A AU 2015296304A AU 2015296304 A AU2015296304 A AU 2015296304A AU 2015296304 B2 AU2015296304 B2 AU 2015296304B2
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Australia
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lipid
mixture
fatty acids
separate
present
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AU2015296304A1 (en
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Steven Watkins
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Metabolon Inc
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Metabolon Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G01N2496/80—Multi-analyte reference solutions containing cholesterol, glucose and the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2015296304A 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids Active AU2015296304B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462031099P 2014-07-30 2014-07-30
US62/031,099 2014-07-30
PCT/US2015/042904 WO2016019140A1 (en) 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids

Publications (2)

Publication Number Publication Date
AU2015296304A1 AU2015296304A1 (en) 2017-02-02
AU2015296304B2 true AU2015296304B2 (en) 2019-08-29

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Family Applications (1)

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AU2015296304A Active AU2015296304B2 (en) 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids

Country Status (8)

Country Link
US (1) US11181535B2 (enExample)
EP (1) EP3174991B1 (enExample)
JP (1) JP6810023B2 (enExample)
CN (1) CN107075539B (enExample)
AU (1) AU2015296304B2 (enExample)
CA (1) CA2955204A1 (enExample)
ES (1) ES2978375T3 (enExample)
WO (1) WO2016019140A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3602605A4 (en) * 2017-03-31 2020-12-30 Metabolon, Inc. COMPREHENSIVE AND QUANTITATIVE LIPID AND TOCOPHEROL ANALYSIS
JP7306676B2 (ja) * 2019-02-26 2023-07-11 国立大学法人九州大学 脂質プロファイリングシステム、脂質プロファイリング方法、及び脂質プロファイリングプログラム
CN114144679A (zh) * 2019-06-04 2022-03-04 阿凡提极性脂质有限责任公司 用于脂质组学中的通用脂质定量标准
CN110609097A (zh) * 2019-09-12 2019-12-24 谱尼测试集团股份有限公司 一种磷脂酰丝氨酸类化合物的筛查方法
CN116106283B (zh) * 2023-02-16 2025-07-29 清华大学 缩醛磷脂的荧光分析方法与应用
CN116879415A (zh) * 2023-05-25 2023-10-13 厦门市迈理奥科技有限公司 一种脂质组学分析内标及其用途和检测方法
EP4741813A1 (en) * 2023-07-03 2026-05-13 Shimadzu Corporation Analysis method using lysophosphatidylcholine compound containing stable isotope element in choline moiety

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100159540A1 (en) * 2007-03-26 2010-06-24 Ana Rodriguez Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
EP2345897A1 (en) * 2010-01-18 2011-07-20 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Improved method for the detection of polyunsaturated fatty acids
WO2014016586A1 (en) * 2012-07-24 2014-01-30 University Of Dundee Isotopic labelling of proteins

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US4224031A (en) * 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
GB0128498D0 (en) 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
US20040024065A1 (en) 2002-03-11 2004-02-05 Watkins Steven M. Novel metabolic targets and markers
US7306952B2 (en) * 2002-06-26 2007-12-11 Washington University In St. Louis Molecular fingerprinting of triglycerides in biological samples by electrospray ionization tandem mass spectrometry
AU2004256368B2 (en) * 2003-07-11 2010-08-05 Tatiana A. Egorova-Zachernyuk Compositions and methods for stable isotope labelling of biological compounds
CN100567967C (zh) * 2006-08-31 2009-12-09 华南理工大学 一种定量测定纸浆树脂中甘油三酯含量的方法
EP2286236B1 (en) * 2008-05-28 2016-04-20 Basf Se Methods for assessing liver toxicity
US8263413B1 (en) * 2008-10-17 2012-09-11 Andrew S Hansen Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
SG10201405975VA (en) * 2009-10-01 2014-11-27 Phenomenome Discoveries Inc Serum-based biomarkers of pancreatic cancer and uses thereof for diseasedetection and diagnosis
CN101824064A (zh) * 2010-01-29 2010-09-08 上海化工研究院 一种13c标记胆甾醇羧酸酯的合成方法
US10705100B1 (en) * 2013-09-11 2020-07-07 HB Biotech, LLC Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
CN103743851B (zh) * 2014-02-14 2015-06-17 中国农业科学院油料作物研究所 一种食用油中甘油三酯的单柱二维液相色谱-质谱分析方法及其应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100159540A1 (en) * 2007-03-26 2010-06-24 Ana Rodriguez Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
EP2345897A1 (en) * 2010-01-18 2011-07-20 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Improved method for the detection of polyunsaturated fatty acids
WO2014016586A1 (en) * 2012-07-24 2014-01-30 University Of Dundee Isotopic labelling of proteins

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Daren Stephens, "Fatty Acid Mass Spectrometry Protocol Updated 10/11/2007 By Daren Stephens", (2007-10-11), URL: http://www.lipidmaps.org/protocols/PP0000003800.pdf, (2017-11-17) *
Ekroos K et al, Anal. Chem. 2002, 74, p941-949 *
Khalil M B et al, Mass Spectrometry Reviews, 2010, 29, pp 877– 929 *
MOORE JEFF D ET AL, "Quantitation and standardization of lipid internal standards for mass spectroscopy", METHODS IN ENZYMO, ACADEMIC PRESS, US, (2007-01-01), vol. 432, ISSN 0076-6879, pages 351 - 367 *
MURPHY et al., "Mass Spectrometric Analysis of Long-Chain Lipids.", Mass Spectrometry Review, vol. 30, no. 4, (2011-07), (2015-09-25) *

Also Published As

Publication number Publication date
EP3174991A1 (en) 2017-06-07
EP3174991A4 (en) 2018-02-14
CA2955204A1 (en) 2016-02-04
JP2017524708A (ja) 2017-08-31
AU2015296304A1 (en) 2017-02-02
CN107075539B (zh) 2021-11-12
WO2016019140A1 (en) 2016-02-04
JP6810023B2 (ja) 2021-01-06
EP3174991B1 (en) 2024-03-20
US20170192023A1 (en) 2017-07-06
US11181535B2 (en) 2021-11-23
CN107075539A (zh) 2017-08-18
ES2978375T3 (es) 2024-09-11

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