JP6810023B2 - 構造的に多様な複合脂質を分析するための方法、組成物およびキット - Google Patents

構造的に多様な複合脂質を分析するための方法、組成物およびキット Download PDF

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JP6810023B2
JP6810023B2 JP2017505546A JP2017505546A JP6810023B2 JP 6810023 B2 JP6810023 B2 JP 6810023B2 JP 2017505546 A JP2017505546 A JP 2017505546A JP 2017505546 A JP2017505546 A JP 2017505546A JP 6810023 B2 JP6810023 B2 JP 6810023B2
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lipid
fatty acid
internal standard
mixture
acid residues
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JP2017524708A5 (enExample
JP2017524708A (ja
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ワトキンス スティーブン
ワトキンス スティーブン
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メタボロン，インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2496/00—Reference solutions for assays of biological material
    • G01N2496/80—Multi-analyte reference solutions containing cholesterol, glucose and the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control

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  • Health & Medical Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
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  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2017505546A 2014-07-30 2015-07-30 構造的に多様な複合脂質を分析するための方法、組成物およびキット Active JP6810023B2 (ja)

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US201462031099P 2014-07-30 2014-07-30
US62/031,099 2014-07-30
PCT/US2015/042904 WO2016019140A1 (en) 2014-07-30 2015-07-30 Methods, compositions, and kits for analysis of structurally diverse complex lipids

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JP2017524708A JP2017524708A (ja) 2017-08-31
JP2017524708A5 JP2017524708A5 (enExample) 2018-09-06
JP6810023B2 true JP6810023B2 (ja) 2021-01-06

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US (1) US11181535B2 (enExample)
EP (1) EP3174991B1 (enExample)
JP (1) JP6810023B2 (enExample)
CN (1) CN107075539B (enExample)
AU (1) AU2015296304B2 (enExample)
CA (1) CA2955204A1 (enExample)
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WO (1) WO2016019140A1 (enExample)

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US20200033360A1 (en) * 2017-03-31 2020-01-30 Metabolon, Inc. Comprehensive and quantitative lipid and tocopherol analysis
JP7306676B2 (ja) * 2019-02-26 2023-07-11 国立大学法人九州大学 脂質プロファイリングシステム、脂質プロファイリング方法、及び脂質プロファイリングプログラム
CN114144679A (zh) * 2019-06-04 2022-03-04 阿凡提极性脂质有限责任公司 用于脂质组学中的通用脂质定量标准
CN110609097A (zh) * 2019-09-12 2019-12-24 谱尼测试集团股份有限公司 一种磷脂酰丝氨酸类化合物的筛查方法
CN116106283B (zh) * 2023-02-16 2025-07-29 清华大学 缩醛磷脂的荧光分析方法与应用
WO2025009258A1 (ja) * 2023-07-03 2025-01-09 株式会社島津製作所 コリン部分に安定同位体元素を含むリゾホスファチジルコリン化合物を用いた分析方法

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US4224031A (en) * 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
GB0128498D0 (en) 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
EP1490076A4 (en) 2002-03-11 2010-01-06 Lipomics Technologies Inc NEW METABOLIC TARGETS AND MARKERS
US7306952B2 (en) * 2002-06-26 2007-12-11 Washington University In St. Louis Molecular fingerprinting of triglycerides in biological samples by electrospray ionization tandem mass spectrometry
CA2532038C (en) * 2003-07-11 2013-11-26 Tatiana A. Egorova-Zachernyuk Compositions and methods for stable isotope labelling of biological compounds
CN100567967C (zh) * 2006-08-31 2009-12-09 华南理工大学 一种定量测定纸浆树脂中甘油三酯含量的方法
WO2008118457A2 (en) * 2007-03-26 2008-10-02 University Of Medicine And Dentistry Of Nj Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
CN102105792A (zh) * 2008-05-28 2011-06-22 巴斯夫欧洲公司 评估肝毒性的工具和方法
US8263413B1 (en) * 2008-10-17 2012-09-11 Andrew S Hansen Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
US10024857B2 (en) 2009-10-01 2018-07-17 Med-Life Discoveries Lp Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis
EP2345897A1 (en) * 2010-01-18 2011-07-20 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Improved method for the detection of polyunsaturated fatty acids
CN101824064A (zh) * 2010-01-29 2010-09-08 上海化工研究院 一种13c标记胆甾醇羧酸酯的合成方法
GB201213127D0 (en) * 2012-07-24 2012-09-05 Univ Dundee Novel isotopic labelling method
US10705100B1 (en) * 2013-09-11 2020-07-07 HB Biotech, LLC Methods for analyzing lipids and membrane proteins in biological matter using stable isotopes and mass spectrometry
CN103743851B (zh) * 2014-02-14 2015-06-17 中国农业科学院油料作物研究所 一种食用油中甘油三酯的单柱二维液相色谱-质谱分析方法及其应用

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ES2978375T3 (es) 2024-09-11
JP2017524708A (ja) 2017-08-31
EP3174991B1 (en) 2024-03-20
AU2015296304A1 (en) 2017-02-02
CN107075539A (zh) 2017-08-18
US11181535B2 (en) 2021-11-23
WO2016019140A1 (en) 2016-02-04
EP3174991A1 (en) 2017-06-07
US20170192023A1 (en) 2017-07-06
AU2015296304B2 (en) 2019-08-29
CA2955204A1 (en) 2016-02-04
CN107075539B (zh) 2021-11-12
EP3174991A4 (en) 2018-02-14

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