AU2015277637B2 - Apparatus and methods for magnetic mixing - Google Patents
Apparatus and methods for magnetic mixing Download PDFInfo
- Publication number
- AU2015277637B2 AU2015277637B2 AU2015277637A AU2015277637A AU2015277637B2 AU 2015277637 B2 AU2015277637 B2 AU 2015277637B2 AU 2015277637 A AU2015277637 A AU 2015277637A AU 2015277637 A AU2015277637 A AU 2015277637A AU 2015277637 B2 AU2015277637 B2 AU 2015277637B2
- Authority
- AU
- Australia
- Prior art keywords
- shaft
- chamber
- magnetically responsive
- responsive component
- magnet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims abstract description 45
- 238000002156 mixing Methods 0.000 title claims abstract description 30
- 238000003752 polymerase chain reaction Methods 0.000 claims description 93
- 239000003153 chemical reaction reagent Substances 0.000 claims description 44
- 230000008569 process Effects 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 230000003321 amplification Effects 0.000 claims description 15
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 15
- 108020004707 nucleic acids Proteins 0.000 claims description 15
- 150000007523 nucleic acids Chemical class 0.000 claims description 15
- 102000039446 nucleic acids Human genes 0.000 claims description 15
- 229910001220 stainless steel Inorganic materials 0.000 claims description 11
- 239000010935 stainless steel Substances 0.000 claims description 11
- 238000010839 reverse transcription Methods 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 230000003287 optical effect Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- -1 nucleoside triphosphates Chemical class 0.000 claims description 4
- 229910052779 Neodymium Inorganic materials 0.000 claims description 2
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 claims description 2
- 239000002777 nucleoside Substances 0.000 claims description 2
- 239000008188 pellet Substances 0.000 claims description 2
- 239000001226 triphosphate Substances 0.000 claims description 2
- 235000011178 triphosphate Nutrition 0.000 claims description 2
- 230000033001 locomotion Effects 0.000 description 13
- 239000000463 material Substances 0.000 description 11
- 230000036961 partial effect Effects 0.000 description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 230000004907 flux Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
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- 238000003757 reverse transcription PCR Methods 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 108091093088 Amplicon Proteins 0.000 description 2
- 102000004533 Endonucleases Human genes 0.000 description 2
- 108010042407 Endonucleases Proteins 0.000 description 2
- 108060002716 Exonuclease Proteins 0.000 description 2
- 239000012807 PCR reagent Substances 0.000 description 2
- 230000001351 cycling effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- HOWGUJZVBDQJKV-UHFFFAOYSA-N docosane Chemical compound CCCCCCCCCCCCCCCCCCCCCC HOWGUJZVBDQJKV-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 102000013165 exonuclease Human genes 0.000 description 2
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- 230000000670 limiting effect Effects 0.000 description 2
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- 125000003729 nucleotide group Chemical group 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 230000004075 alteration Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
- B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/813—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles mixing simultaneously in two or more mixing receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
- B01F2035/99—Heating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Power Engineering (AREA)
- Electromagnetism (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462013648P | 2014-06-18 | 2014-06-18 | |
| US62/013,648 | 2014-06-18 | ||
| PCT/US2015/034332 WO2015195357A1 (en) | 2014-06-18 | 2015-06-05 | Apparatus and methods for magnetic mixing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015277637A1 AU2015277637A1 (en) | 2017-01-05 |
| AU2015277637B2 true AU2015277637B2 (en) | 2019-03-28 |
Family
ID=54869086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015277637A Ceased AU2015277637B2 (en) | 2014-06-18 | 2015-06-05 | Apparatus and methods for magnetic mixing |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10179899B2 (enExample) |
| EP (2) | EP3157658B1 (enExample) |
| JP (2) | JP6491240B2 (enExample) |
| KR (2) | KR102381695B1 (enExample) |
| CN (2) | CN110575781B (enExample) |
| AU (1) | AU2015277637B2 (enExample) |
| CA (1) | CA2951649C (enExample) |
| WO (1) | WO2015195357A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015195357A1 (en) | 2014-06-18 | 2015-12-23 | Luminex Corporation | Apparatus and methods for magnetic mixing |
| FR3038526A1 (fr) * | 2015-07-06 | 2017-01-13 | Provaine | Systeme de fabrication d'une formulation |
| US10953376B2 (en) * | 2015-09-03 | 2021-03-23 | Tetracore, Inc. | Device and method for mixing and bubble removal |
| CN113015910A (zh) * | 2019-04-22 | 2021-06-22 | 深圳迈瑞生物医疗电子股份有限公司 | 一种磁珠试剂的混匀装置、混匀方法以及样本分析设备 |
| KR102092003B1 (ko) * | 2019-12-05 | 2020-05-15 | 한창기전 주식회사 | 산화 및 전처리 장치 일체형 유체이동 시스템을 탑재한 총인 및 총질소 측정시스템 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911555A (en) * | 1989-05-04 | 1990-03-27 | The Jackson Laboratory | Magnetic stirrer for multiple samples |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US2774803A (en) * | 1952-09-20 | 1956-12-18 | Asea Ab | Inductive stirring device for metallurgical furnace |
| FR2109370A5 (enExample) * | 1970-10-14 | 1972-05-26 | Bernard Du Grail Alain | |
| US4040605A (en) * | 1976-07-14 | 1977-08-09 | Marvin Stanley Towsend | Magnetic stirring apparatus |
| US5306510A (en) | 1988-01-14 | 1994-04-26 | Cyberlab, Inc. | Automated pipetting system |
| US5352036A (en) | 1992-09-23 | 1994-10-04 | Habley Medical Technology Corporation | Method for mixing and dispensing a liquid pharmaceutical with a miscible component |
| US5599660A (en) | 1993-01-19 | 1997-02-04 | Pharmacia Biotech Inc. | Method and preparation for sequential delivery of wax-embedded, inactivated biological and chemical reagents |
| JPH09500826A (ja) | 1993-07-30 | 1997-01-28 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 向流多相液体分離のための装置 |
| DE19644302A1 (de) | 1995-11-28 | 1997-06-05 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis von Telomerase-Aktivität |
| DE69839294T2 (de) * | 1997-09-29 | 2009-04-09 | F. Hoffmann-La Roche Ag | Gerät zur Abscheidung magnetischer Teilchen |
| US6086831A (en) * | 1998-06-10 | 2000-07-11 | Mettler-Toledo Bohdan, Inc. | Modular reaction block assembly with thermoelectric cooling and heating |
| US6176609B1 (en) | 1998-10-13 | 2001-01-23 | V & P Scientific, Inc. | Magnetic tumble stirring method, devices and machines for mixing in vessels |
| US6793167B2 (en) * | 1999-01-12 | 2004-09-21 | Island Oasis Cocktail Company, Inc. | Food processing apparatus including magnetic drive |
| US6357907B1 (en) | 1999-06-15 | 2002-03-19 | V & P Scientific, Inc. | Magnetic levitation stirring devices and machines for mixing in vessels |
| AU5776400A (en) | 1999-06-30 | 2001-01-31 | Quidel Corporation | Method and kit for measuring total pyridinium crosslinks |
| JP2003506708A (ja) * | 1999-08-05 | 2003-02-18 | ブライアン・ウィリアム・キング | 直接吸引反応も注入も可能なデバイスならびにその使用方法 |
| US6382827B1 (en) | 2000-11-01 | 2002-05-07 | Dade Behring Inc. | Method and apparatus for mixing liquid solutions using a rotating magnet to generate a stirring vortex action |
| JP2002152308A (ja) * | 2000-11-09 | 2002-05-24 | Nec Corp | データ通信システム、その通信方法及びその通信プログラムを記録した記録媒体 |
| EP1243315A1 (en) * | 2001-03-22 | 2002-09-25 | Avantium International B.V. | Stirring device and method for measuring a parameter of the substance to be stirred |
| US6467946B1 (en) | 2001-04-24 | 2002-10-22 | Dade Microscan Inc. | Method and apparatus for mixing liquid samples in a container using rotating magnetic fields |
| US20030017620A1 (en) * | 2001-06-21 | 2003-01-23 | Carron Keith T. | Lyophilization of colloidal metals for surface enhanced Raman scattering |
| US6461034B1 (en) | 2001-11-14 | 2002-10-08 | V & P Scientific, Inc. | Use of a bubble paddle tumble stirrer to mix the contents of a vessel while the contents are being removed |
| US20040053319A1 (en) | 2002-09-17 | 2004-03-18 | Mcwilliams Diana R. | Isolation of genetic molecules from a complex biological constrauct for use in genetic expression analysis |
| US7351337B1 (en) | 2003-11-07 | 2008-04-01 | Chester Milo | Magnetic fuel conditioning apparatus |
| US7484880B2 (en) | 2005-06-24 | 2009-02-03 | V & P Scientific, Inc. | Vortex stirring of vessels in a two-dimensional array |
| JP4981295B2 (ja) * | 2005-10-04 | 2012-07-18 | キヤノン株式会社 | Ｄｎａ処理方法およびｄｎａ処理装置 |
| CN101522294B (zh) * | 2006-06-21 | 2012-05-16 | 斯彼诺米克斯公司 | 一种用于处理和混合液体介质中的磁性颗粒的设备和方法 |
| CN101466460A (zh) * | 2006-07-14 | 2009-06-24 | 西格玛-奥尔德利希公司 | 磁力搅拌器 |
| CA2754884C (en) | 2007-06-21 | 2013-04-30 | Gen-Probe Incorporated | Methods of concentrating an analyte |
| US7791441B1 (en) * | 2008-04-15 | 2010-09-07 | Jefferson George F | Magnetically powered spinning magnet |
| EP2349549B1 (en) | 2008-09-16 | 2012-07-18 | Ibis Biosciences, Inc. | Mixing cartridges, mixing stations, and related kits, and system |
| WO2010089138A1 (en) * | 2009-02-09 | 2010-08-12 | Caprotec Bioanalytics Gmbh | Devices, systems and methods for separating magnetic particles |
| FR2972646B1 (fr) * | 2011-03-14 | 2015-02-27 | Total Sa | Melange d'un fluide multiphase |
| US9340417B2 (en) * | 2011-06-29 | 2016-05-17 | The Regents Of The University Of California | Magnetic recovery method of magnetically responsive high-aspect ratio photoresist microstructures |
| US8657484B1 (en) * | 2012-01-18 | 2014-02-25 | The United States Of America As Represented By The Secretary Of The Army | Apparatus for mixing contents enclosed within a container |
| DE102012201475B4 (de) * | 2012-02-01 | 2014-12-18 | Gna Biosolutions Gmbh | Verfahren zum Vervielfältigen von Nukleinsäuren |
| EP2864495A4 (en) * | 2012-06-20 | 2016-06-08 | Bio Rad Laboratories | STABILIZED DROPLETS FOR CALIBRATING AND TESTING |
| WO2015195357A1 (en) | 2014-06-18 | 2015-12-23 | Luminex Corporation | Apparatus and methods for magnetic mixing |
-
2015
- 2015-06-05 WO PCT/US2015/034332 patent/WO2015195357A1/en not_active Ceased
- 2015-06-05 CN CN201910773669.7A patent/CN110575781B/zh not_active Expired - Fee Related
- 2015-06-05 EP EP15809156.1A patent/EP3157658B1/en active Active
- 2015-06-05 EP EP21170510.8A patent/EP3892366A1/en not_active Withdrawn
- 2015-06-05 KR KR1020177001571A patent/KR102381695B1/ko active Active
- 2015-06-05 CN CN201580037764.0A patent/CN106488799B/zh not_active Expired - Fee Related
- 2015-06-05 JP JP2016573903A patent/JP6491240B2/ja not_active Expired - Fee Related
- 2015-06-05 CA CA2951649A patent/CA2951649C/en active Active
- 2015-06-05 AU AU2015277637A patent/AU2015277637B2/en not_active Ceased
- 2015-06-05 US US14/731,459 patent/US10179899B2/en active Active
- 2015-06-05 KR KR1020227010091A patent/KR102513883B1/ko active Active
-
2018
- 2018-11-28 US US16/202,315 patent/US10851336B2/en not_active Expired - Fee Related
-
2019
- 2019-02-28 JP JP2019035341A patent/JP6754458B2/ja not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911555A (en) * | 1989-05-04 | 1990-03-27 | The Jackson Laboratory | Magnetic stirrer for multiple samples |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015277637A1 (en) | 2017-01-05 |
| WO2015195357A1 (en) | 2015-12-23 |
| JP6754458B2 (ja) | 2020-09-09 |
| CN106488799B (zh) | 2019-10-08 |
| JP2019110913A (ja) | 2019-07-11 |
| CN110575781B (zh) | 2022-07-29 |
| KR102513883B1 (ko) | 2023-03-24 |
| KR20220044381A (ko) | 2022-04-07 |
| US20190093061A1 (en) | 2019-03-28 |
| EP3892366A1 (en) | 2021-10-13 |
| KR102381695B1 (ko) | 2022-04-01 |
| CN106488799A (zh) | 2017-03-08 |
| JP6491240B2 (ja) | 2019-03-27 |
| EP3157658B1 (en) | 2021-10-13 |
| US10179899B2 (en) | 2019-01-15 |
| KR20170018957A (ko) | 2017-02-20 |
| CN110575781A (zh) | 2019-12-17 |
| US20150368601A1 (en) | 2015-12-24 |
| EP3157658A1 (en) | 2017-04-26 |
| EP3157658A4 (en) | 2018-02-21 |
| CA2951649A1 (en) | 2015-12-23 |
| US10851336B2 (en) | 2020-12-01 |
| CA2951649C (en) | 2023-10-03 |
| JP2017524352A (ja) | 2017-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |