AU2015240806B2 - Conjugates of an IL-15 moiety and a polymer - Google Patents

Conjugates of an IL-15 moiety and a polymer Download PDF

Info

Publication number
AU2015240806B2
AU2015240806B2 AU2015240806A AU2015240806A AU2015240806B2 AU 2015240806 B2 AU2015240806 B2 AU 2015240806B2 AU 2015240806 A AU2015240806 A AU 2015240806A AU 2015240806 A AU2015240806 A AU 2015240806A AU 2015240806 B2 AU2015240806 B2 AU 2015240806B2
Authority
AU
Australia
Prior art keywords
moiety
conjugate
daltons
polymer
och
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015240806A
Other languages
English (en)
Other versions
AU2015240806A1 (en
Inventor
Thomas Chang
Deborah H. Charych
Peter Benedict Kirk
Xiaofeng Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of AU2015240806A1 publication Critical patent/AU2015240806A1/en
Application granted granted Critical
Publication of AU2015240806B2 publication Critical patent/AU2015240806B2/en
Priority to AU2019283778A priority Critical patent/AU2019283778A1/en
Priority to AU2021258008A priority patent/AU2021258008A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2015240806A 2014-04-03 2015-04-01 Conjugates of an IL-15 moiety and a polymer Active AU2015240806B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2019283778A AU2019283778A1 (en) 2014-04-03 2019-12-16 Conjugates of an IL-15 moiety and a polymer
AU2021258008A AU2021258008A1 (en) 2014-04-03 2021-10-28 Conjugates of an IL-15 moiety and a polymer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461974914P 2014-04-03 2014-04-03
US61/974,914 2014-04-03
PCT/US2015/023871 WO2015153753A2 (en) 2014-04-03 2015-04-01 Conjugates of an il-15 moiety and a polymer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019283778A Division AU2019283778A1 (en) 2014-04-03 2019-12-16 Conjugates of an IL-15 moiety and a polymer

Publications (2)

Publication Number Publication Date
AU2015240806A1 AU2015240806A1 (en) 2016-10-13
AU2015240806B2 true AU2015240806B2 (en) 2019-09-19

Family

ID=54241432

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2015240806A Active AU2015240806B2 (en) 2014-04-03 2015-04-01 Conjugates of an IL-15 moiety and a polymer
AU2019283778A Abandoned AU2019283778A1 (en) 2014-04-03 2019-12-16 Conjugates of an IL-15 moiety and a polymer
AU2021258008A Abandoned AU2021258008A1 (en) 2014-04-03 2021-10-28 Conjugates of an IL-15 moiety and a polymer

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2019283778A Abandoned AU2019283778A1 (en) 2014-04-03 2019-12-16 Conjugates of an IL-15 moiety and a polymer
AU2021258008A Abandoned AU2021258008A1 (en) 2014-04-03 2021-10-28 Conjugates of an IL-15 moiety and a polymer

Country Status (12)

Country Link
US (1) US20170035898A1 (https=)
EP (2) EP3919071A1 (https=)
JP (2) JP6728055B2 (https=)
KR (1) KR102432169B1 (https=)
CN (1) CN106456716A (https=)
AU (3) AU2015240806B2 (https=)
CA (1) CA2942571C (https=)
ES (1) ES2876433T3 (https=)
IL (1) IL248169A0 (https=)
MA (1) MA39711A (https=)
MX (2) MX388865B (https=)
WO (1) WO2015153753A2 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2986306A4 (en) 2013-04-18 2016-12-07 Armo Biosciences Inc METHOD FOR USE OF INTERLEUKIN-10 FOR THE TREATMENT OF ILLNESSES AND SUFFERING
ES2688206T3 (es) 2013-06-17 2018-10-31 Armo Biosciences, Inc. Procedimiento de evaluación de la identidad y la estabilidad de proteínas
CN105658232A (zh) 2013-08-30 2016-06-08 阿尔莫生物科技股份有限公司 使用白细胞介素-10治疗疾病和病症的方法
EP3068425B1 (en) 2013-11-11 2021-01-27 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
WO2015187295A2 (en) 2014-06-02 2015-12-10 Armo Biosciences, Inc. Methods of lowering serum cholesterol
WO2016060996A2 (en) 2014-10-14 2016-04-21 Armo Biosciences, Inc. Interleukin-15 compositions and uses thereof
AU2015336101A1 (en) 2014-10-22 2017-04-20 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
US10618970B2 (en) 2015-02-03 2020-04-14 Armo Biosciences, Inc. Method of treating cancer with IL-10 and antibodies that induce ADCC
CA2986755A1 (en) 2015-05-28 2016-12-01 Armo Biosciences, Inc. Pegylated interleukin-10 for use in treating cancer
US10398761B2 (en) 2015-08-25 2019-09-03 Armo Biosciences, Inc. Methods of using combinations of PEG-IL-10 and IL-15 for treating cancers
AU2016335860B2 (en) 2015-10-08 2023-08-10 Nektar Therapeutics Combination of an IL-2Rbeta-selective agonist and a long-acting IL-15 agonist
US20180360977A1 (en) * 2015-12-21 2018-12-20 Armo Biosciences, Inc. Interleukin-15 Compositions and Uses Thereof
JP7185530B2 (ja) 2016-06-13 2022-12-07 トルク セラピューティクス， インコーポレイテッド 免疫細胞機能を促進するための方法および組成物
US12036283B2 (en) * 2017-05-15 2024-07-16 Nektar Therapeutics Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods
JP7285828B2 (ja) 2017-09-05 2023-06-02 トルク セラピューティクス， インコーポレイテッド 治療用タンパク質組成物ならびにその作製および使用方法
CA3091857A1 (en) * 2018-02-26 2019-08-29 Synthorx, Inc. Il-15 conjugates and uses thereof
WO2020097556A1 (en) * 2018-11-09 2020-05-14 Nektar Therapeutics Long-acting interleukin-15 receptor agonist in combination with another pharmacologically active agent
KR20220004134A (ko) * 2019-04-26 2022-01-11 프로린크스 엘엘시 서방형 사이토카인 컨쥬게이트
WO2020247388A2 (en) 2019-06-03 2020-12-10 Medikine, Inc. Il-2alpha receptor subunit binding compounds
CN114555632A (zh) * 2019-08-23 2022-05-27 新索思股份有限公司 Il-15缀合物及其用途
AU2022249281B2 (en) * 2021-03-29 2025-08-14 Aj Sciences (Yixing) Co., Ltd Protein-macromolecule conjugates and methods of use thereof
CN117597355A (zh) 2021-06-23 2024-02-23 赛腾制药 白细胞介素15变体
EP4370536A4 (en) * 2021-07-12 2026-04-22 Nektar Therapeutics MODIFIED POLYMER FORMS OF INTERFERON-GAMMA AND METHODS OF USE
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
US20250222027A1 (en) 2022-04-01 2025-07-10 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
WO2025101551A1 (en) * 2023-11-06 2025-05-15 Regents Of The University Of Minnesota Prostate-specific membrane antigen (psma)-binding peptides and method of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253587A1 (en) * 1995-02-22 2004-12-16 Immunex Corporation Antagonists of interleukin-15
WO2012016131A1 (en) * 2010-07-30 2012-02-02 Baxter International Inc. Nucleophilic catalysts for oxime linkage

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
EP0728210B1 (en) * 1993-11-12 2005-04-13 Gilead Sciences, Inc. Thrombin mutants
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
PT772624E (pt) 1994-04-06 2001-03-30 Immunex Corp Interleucina-15
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
DK1411075T3 (da) 1998-03-12 2008-10-27 Nektar Therapeutics Al Corp Fremgangsmåde til fremstilling af polymerkonjugater
WO2001062827A2 (en) 2000-02-22 2001-08-30 Shearwater Corporation N-maleimidyl polymer derivatives
WO2004060965A2 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
EP1581582B2 (en) 2003-01-06 2017-06-07 Nektar Therapeutics Thiol-selective water-soluble polmer derivatives
US7276478B2 (en) * 2003-09-25 2007-10-02 Zymogenetics, Inc. Methods of treating autoimmune diseases using IL-21
US20060057680A1 (en) * 2004-08-11 2006-03-16 Zheng Xin X Mutant interleukin-15 polypeptides
JP2008515896A (ja) 2004-10-05 2008-05-15 オクスナー クリニック ファウンデーション Ｉｌ−１５によるｂ細胞増殖の増強
US20060257361A1 (en) * 2005-04-12 2006-11-16 Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services Novel form of interleukin-15, Fc-IL-15, and methods of use
BRPI0611872B8 (pt) 2005-06-16 2021-05-25 Nektar Therapeutics reagente polimérico, conjugado, método para preparação de um conjugado e composição farmacêutica
KR101508621B1 (ko) 2007-02-28 2015-04-07 세리나 쎄라퓨틱스, 인코포레이티드 활성화된 폴리옥사졸린 및 이를 포함하는 조성물
CA2740904C (en) * 2008-10-21 2019-01-15 Baxter International Inc. Methods for determining active ingredients in pro-drug peg protein conjugates with releasable peg reagents (in vitro de-pegylation)
ES2866674T3 (es) * 2010-11-12 2021-10-19 Nektar Therapeutics Conjugados de una fracción de IL-2 y un polímero
CN102145178B (zh) * 2011-04-15 2012-09-26 北京凯因科技股份有限公司 Peg化白介素15
WO2013020079A2 (en) * 2011-08-04 2013-02-07 Nektar Therapeutics Conjugates of an il-11 moiety and a polymer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253587A1 (en) * 1995-02-22 2004-12-16 Immunex Corporation Antagonists of interleukin-15
WO2012016131A1 (en) * 2010-07-30 2012-02-02 Baxter International Inc. Nucleophilic catalysts for oxime linkage

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAILON PASCAL ET AL, "PEG-modified biopharmaceuticals", EXPERT OPINION ON DRUG DELI, INFORMA HEALTHCARE, GB, (2009-01-01), vol. 6, no. 1, doi:10.1517/17425240802650568, ISSN 1742-5247, pages 1 - 16 *
PETTIT D K ET AL, "POLYETHYLENE GLYCOL CONJUGATION TO LYSINE RESIDUES OF RECOMBINANT IL-15 GENERATES A SPECIFIC IL-15 ANTAGONIST", PROC. INTERN. SYMP. CONTROL. REL. BIOACT. MATER. (1995), vol. 22, page 496/497 *
PETTIT D K ET AL, "STRUCTURE-FUNCTION STUDIES OF INTERLEUKIN 15 USING SITE-SPECIFIC MUTAGENESIS, POLYETHYLENE GLYCOL CONJUGATION, AND HOMOLOGY MODELING", JOURNAL OF BIOLOGICAL CHEMISTRY (1997-01-24), vol. 272, no. 4, pages 2312 - 2318 *

Also Published As

Publication number Publication date
US20170035898A1 (en) 2017-02-09
AU2019283778A1 (en) 2020-01-16
EP3139947A4 (en) 2018-01-17
EP3139947B8 (en) 2021-06-30
EP3919071A1 (en) 2021-12-08
WO2015153753A3 (en) 2015-11-26
MA39711A (fr) 2015-10-08
JP2017511322A (ja) 2017-04-20
EP3139947A2 (en) 2017-03-15
WO2015153753A2 (en) 2015-10-08
IL248169A0 (en) 2016-11-30
MX2021015492A (es) 2022-02-22
AU2021258008A1 (en) 2021-11-25
KR102432169B1 (ko) 2022-08-11
AU2015240806A1 (en) 2016-10-13
EP3139947B1 (en) 2021-05-26
MX2016012908A (es) 2017-01-11
CA2942571C (en) 2023-09-19
KR20170005793A (ko) 2017-01-16
JP6728055B2 (ja) 2020-07-22
MX388865B (es) 2025-03-20
CN106456716A (zh) 2017-02-22
ES2876433T3 (es) 2021-11-12
CA2942571A1 (en) 2015-10-08
JP2020114875A (ja) 2020-07-30

Similar Documents

Publication Publication Date Title
AU2015240806B2 (en) Conjugates of an IL-15 moiety and a polymer
US12247059B2 (en) Conjugates of an IL-2 moiety and a polymer
AU2016228555B2 (en) Conjugates of an IL-7 moiety and a polymer
WO2013020079A2 (en) Conjugates of an il-11 moiety and a polymer
HK1235666A1 (en) Conjugates of il-15 and branched polyethylene glycol
HK1235666B (en) Conjugates of il-15 and branched polyethylene glycol
HK40053166A (en) Conjugates of an il-2 moiety and a polymer

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)