AU2015229222C1 - Compositions of human prothrombin and activated factor X for improving hemostasis in the treatment of bleeding disorders - Google Patents

Compositions of human prothrombin and activated factor X for improving hemostasis in the treatment of bleeding disorders Download PDF

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Publication number
AU2015229222C1
AU2015229222C1 AU2015229222A AU2015229222A AU2015229222C1 AU 2015229222 C1 AU2015229222 C1 AU 2015229222C1 AU 2015229222 A AU2015229222 A AU 2015229222A AU 2015229222 A AU2015229222 A AU 2015229222A AU 2015229222 C1 AU2015229222 C1 AU 2015229222C1
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AU
Australia
Prior art keywords
fxa
fii
composition
concentration
use according
Prior art date
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Active
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AU2015229222A
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English (en)
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AU2015229222B2 (en
AU2015229222A1 (en
Inventor
Michael Dockal
Sabine KNAPPE
Friedrich Scheiflinger
Susanne Till
Peter Leopold Turecek
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication date
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Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
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Publication of AU2015229222B2 publication Critical patent/AU2015229222B2/en
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Assigned to TAKEDA PHARMACEUTICAL COMPANY LIMITED reassignment TAKEDA PHARMACEUTICAL COMPANY LIMITED Request for Assignment Assignors: Baxalta GmbH, BAXALTA INCORPORATED
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2015229222A 2014-03-14 2015-03-13 Compositions of human prothrombin and activated factor X for improving hemostasis in the treatment of bleeding disorders Active AU2015229222C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461953496P 2014-03-14 2014-03-14
US61/953,496 2014-03-14
PCT/US2015/020361 WO2015138847A1 (en) 2014-03-14 2015-03-13 Compositions of human prothrombin and activated factor x for improving hemostasis in the treatment of bleeding disorders

Publications (3)

Publication Number Publication Date
AU2015229222A1 AU2015229222A1 (en) 2016-09-29
AU2015229222B2 AU2015229222B2 (en) 2020-08-27
AU2015229222C1 true AU2015229222C1 (en) 2020-12-24

Family

ID=52727470

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015229222A Active AU2015229222C1 (en) 2014-03-14 2015-03-13 Compositions of human prothrombin and activated factor X for improving hemostasis in the treatment of bleeding disorders

Country Status (9)

Country Link
US (2) US20150258182A1 (enExample)
EP (1) EP3116534B1 (enExample)
JP (1) JP6535036B2 (enExample)
CN (1) CN106413744B (enExample)
AU (1) AU2015229222C1 (enExample)
ES (1) ES2742898T3 (enExample)
NZ (1) NZ724105A (enExample)
TW (1) TWI653047B (enExample)
WO (1) WO2015138847A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI653047B (zh) 2014-03-14 2019-03-11 百特製藥公司 用於在出血性病症的治療中促進止血的人類凝血酶原及活化因子x的組成物
SG10201912497WA (en) * 2017-02-09 2020-02-27 Csl Behring Gmbh A blood coagulation factor replacement product for use in the treatment or prophylaxis of bleedings
EP3590528A1 (en) * 2018-07-06 2020-01-08 Octapharma AG Fx activation process and its use in the preparation of a fxa composition
EP4456935A1 (en) 2021-12-30 2024-11-06 Baxter International Inc. Fibrinogen and thrombin solutions for a fibrin sealant and fibrin sealant kit

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866122A (en) * 1996-03-20 1999-02-02 Immuno Aktiengesellschaft Pharmaceutical preparation for treating blood coagulation disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287180A (en) 1980-01-28 1981-09-01 Baxter Travenol Laboratories, Inc. Method for treating blood clotting factor inhibitors
US9956272B2 (en) 2007-05-30 2018-05-01 Bio Products Laboratory Limited Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
CN102905732A (zh) * 2010-03-15 2013-01-30 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的方法
TWI653047B (zh) 2014-03-14 2019-03-11 百特製藥公司 用於在出血性病症的治療中促進止血的人類凝血酶原及活化因子x的組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866122A (en) * 1996-03-20 1999-02-02 Immuno Aktiengesellschaft Pharmaceutical preparation for treating blood coagulation disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
P L Turecek ET AL, "FEIBA: mode of action", Haemophilia : the official journal of the World Federation of Hemophilia, England, (2004-09-01), page 3, URL: http://www.ncbi.nlm.nih.gov/pubmed/15385040 *

Also Published As

Publication number Publication date
US20150258182A1 (en) 2015-09-17
ES2742898T3 (es) 2020-02-17
AU2015229222B2 (en) 2020-08-27
WO2015138847A1 (en) 2015-09-17
JP6535036B2 (ja) 2019-06-26
EP3116534B1 (en) 2019-05-29
TWI653047B (zh) 2019-03-11
AU2015229222A1 (en) 2016-09-29
CN106413744A (zh) 2017-02-15
JP2017508806A (ja) 2017-03-30
US11160850B2 (en) 2021-11-02
US20190231855A1 (en) 2019-08-01
NZ724105A (en) 2023-02-24
TW201620545A (zh) 2016-06-16
EP3116534A1 (en) 2017-01-18
CN106413744B (zh) 2020-09-04

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 07 SEP 2020

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT FILED 07 SEP 2020

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Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Free format text: FORMER OWNER(S): BAXALTA GMBH; BAXALTA INCORPORATED