AU2014369879B2 - Structured substrates for improving detection of light emissions and methods relating to the same - Google Patents

Structured substrates for improving detection of light emissions and methods relating to the same Download PDF

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AU2014369879B2
AU2014369879B2 AU2014369879A AU2014369879A AU2014369879B2 AU 2014369879 B2 AU2014369879 B2 AU 2014369879B2 AU 2014369879 A AU2014369879 A AU 2014369879A AU 2014369879 A AU2014369879 A AU 2014369879A AU 2014369879 B2 AU2014369879 B2 AU 2014369879B2
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nanostructures
cavities
nanoparticles
reaction
layer
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AU2014369879A1 (en
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M. Shane Bowen
Hui Han
Sang Ryul Park
Bala Murali VENKATESAN
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Illumina Inc
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Illumina Inc
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
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    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
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    • C40—COMBINATORIAL TECHNOLOGY
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    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/628—Detection means characterised by use of a special device being a surface plasmon resonance spectrometer

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AU2014369879A 2013-12-23 2014-12-23 Structured substrates for improving detection of light emissions and methods relating to the same Ceased AU2014369879B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361920244P 2013-12-23 2013-12-23
US61/920,244 2013-12-23
PCT/US2014/072256 WO2015100373A2 (en) 2013-12-23 2014-12-23 Structured substrates for improving detection of light emissions and methods relating to the same

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AU2014369879A1 AU2014369879A1 (en) 2016-06-23
AU2014369879B2 true AU2014369879B2 (en) 2020-12-24

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US (2) US20180073065A1 (https=)
EP (2) EP3087181B1 (https=)
JP (1) JP7082860B2 (https=)
KR (2) KR102333635B1 (https=)
CN (1) CN106062212A (https=)
AU (1) AU2014369879B2 (https=)
BR (1) BR112016014923B1 (https=)
CA (2) CA3198424A1 (https=)
ES (1) ES2848062T3 (https=)
WO (1) WO2015100373A2 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015175398A1 (en) 2014-05-12 2015-11-19 President And Fellows Of Harvard College Systems and methods for making and using sensors, probes, and other devices
US9861710B1 (en) * 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
EP3696536A1 (en) 2015-04-14 2020-08-19 Illumina, Inc. A method of manufacturing a substrate and a method of analyzing biomolecules capable of generating light emissions
JP6752231B2 (ja) 2015-06-01 2020-09-09 カリフォルニア インスティテュート オブ テクノロジー 抗原を用いて特異的集団に関してｔ細胞をスクリーニングするための組成物および方法
AT517746B1 (de) * 2015-09-16 2018-03-15 Fianostics Gmbh Substrat
WO2017164403A1 (ja) * 2016-03-25 2017-09-28 大日本印刷株式会社 電磁波応答性積層体
WO2018165475A1 (en) 2017-03-08 2018-09-13 California Institute Of Technology Pairing antigen specificity of a t cell with t cell receptor sequences
CN106873234B (zh) * 2017-03-16 2019-10-25 京东方科技集团股份有限公司 发光显示器件及其制作方法、发光显示装置
WO2018222839A1 (en) 2017-06-01 2018-12-06 Radiabeam Technologies, Llc Split structure particle accelerators
JP7043051B2 (ja) * 2017-09-01 2022-03-29 学校法人関西学院 表面プラズモン励起増強蛍光検出装置および検出方法
EP4427841A3 (en) * 2017-09-08 2024-11-13 President And Fellows Of Harvard College Nanosensor methods and apparatuses for determination of analytes
EP3727674A4 (en) * 2017-12-21 2021-10-13 Illumina Inc. FLOW CELLS WITH HYDROGEL COATING
CN112469852A (zh) * 2018-04-14 2021-03-09 生捷科技控股公司 用于捕获dna分子的dna桥方法
JP7398639B2 (ja) * 2018-08-24 2023-12-15 パナソニックＩｐマネジメント株式会社 金属微細構造体および検出装置
CN112005101A (zh) * 2018-08-28 2020-11-27 松下知识产权经营株式会社 传感器基板及其制造方法
US20210345616A1 (en) * 2018-09-06 2021-11-11 Ramot At Tel-Aviv University Ltd. Method of producing metal nanoparticles and uses thereof
US11612049B2 (en) 2018-09-21 2023-03-21 Radiabeam Technologies, Llc Modified split structure particle accelerators
KR102821103B1 (ko) 2018-12-17 2025-06-13 일루미나, 인코포레이티드 유동 셀 및 시퀀싱 키트
CN113826011A (zh) 2019-02-27 2021-12-21 纳米马赛克公司 纳米传感器及其用途
NL2023516B1 (en) * 2019-05-28 2020-12-08 Illumina Inc Manufacturing a flowcell with a planar waveguide
CN110218628B (zh) * 2019-06-19 2021-01-29 中国科学院半导体研究所 一种数字pcr芯片及其制备方法
JP7664639B2 (ja) * 2020-04-20 2025-04-18 公立大学法人大阪 センサー
MX2022014810A (es) * 2020-11-16 2023-03-06 Illumina Cambridge Ltd Alteración de señales de celdas de flujo.
JP2023548869A (ja) * 2020-11-16 2023-11-21 イルミナ ケンブリッジ リミテッド 官能化プラズモンナノ構造
WO2022215038A1 (en) 2021-04-07 2022-10-13 3M Innovative Properties Company Fluorescence enhancement films for luminescent imaging
KR102760542B1 (ko) * 2021-06-29 2025-02-03 광주과학기술원 측면 흐름 분석-기반의 면역 검출용 이중 나노입자 및 이를 이용한 면역 검출 센서
WO2023205353A1 (en) * 2022-04-21 2023-10-26 Ultima Genomics, Inc. Self assembly of beads on substrates
KR102830132B1 (ko) * 2022-05-18 2025-07-07 주식회사 케이티앤지 발열체 및 이를 포함하는 에어로졸 발생 장치
US12055737B2 (en) * 2022-05-18 2024-08-06 GE Precision Healthcare LLC Aligned and stacked high-aspect ratio metallized structures
US12515223B2 (en) 2022-10-24 2026-01-06 Samsung Electronics Co., Ltd. 3D-tapered nanocavities with on-chip optical and molecular concentration for single molecule diagnostics
CN115639185B (zh) * 2022-11-04 2025-07-15 东南大学 一种a-b-a纳米三聚体阵列的制备方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013063382A2 (en) * 2011-10-28 2013-05-02 Illumina, Inc. Microarray fabrication system and method

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US7172864B1 (en) * 1993-11-01 2007-02-06 Nanogen Methods for electronically-controlled enzymatic reactions
US5552278A (en) 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20050244870A1 (en) 1999-04-20 2005-11-03 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
DK1259643T3 (da) 2000-02-07 2009-02-23 Illumina Inc Fremgangsmåde til detektion af nukleinsyre ved anvendelse af universel priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
ATE377093T1 (de) 2000-07-07 2007-11-15 Visigen Biotechnologies Inc Sequenzbestimmung in echtzeit
US6706479B2 (en) * 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
AU2002227156A1 (en) 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US6960298B2 (en) * 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
WO2004018497A2 (en) 2002-08-23 2004-03-04 Solexa Limited Modified nucleotides for polynucleotide sequencing
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
WO2005003304A2 (en) 2003-06-20 2005-01-13 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
EP1701785A1 (en) 2004-01-07 2006-09-20 Solexa Ltd. Modified molecular arrays
CA2579150C (en) 2004-09-17 2014-11-25 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
US7274458B2 (en) * 2005-03-07 2007-09-25 3M Innovative Properties Company Thermoplastic film having metallic nanoparticle coating
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
CA2648149A1 (en) 2006-03-31 2007-11-01 Solexa, Inc. Systems and devices for sequence by synthesis analysis
EP2066814A4 (en) * 2006-09-14 2010-12-29 Univ California MOLECULAR NANOPLASMONIC LINEAL FOR NUCLEASE ACTIVITY AND DNA FOOTPRINT
US8343746B2 (en) 2006-10-23 2013-01-01 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
JP5268444B2 (ja) * 2008-06-23 2013-08-21 株式会社日立ハイテクノロジーズ 単分子リアルタイムシーケンス装置，核酸分析装置及び単分子リアルタイムシーケンス方法
WO2010029175A1 (en) * 2008-09-12 2010-03-18 Modpro Ab Detection method and device based on nanoparticle aggregation
KR101041606B1 (ko) * 2009-08-18 2011-06-15 (주)아벨리노 다중 스팟 금속 증착형 나노구조배열 각막이상증 진단용 핵산칩 및 이의 제조방법
CN202281746U (zh) 2010-03-06 2012-06-20 伊鲁米那股份有限公司 检测来自样品光信号的测定设备及其光学组件和光学系统
WO2011159942A1 (en) 2010-06-18 2011-12-22 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
EP2606154B1 (en) * 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2012103110A2 (en) 2011-01-24 2012-08-02 Mohammad Naraghi Building facade surface for seasonal selectiveness of solar irradiation absorption and reflection
WO2012122418A1 (en) * 2011-03-08 2012-09-13 Lightspeed Genomics, Inc. Self-assembling high density ordered patterned biomolecule array and method for making and using the same
US9671327B2 (en) * 2011-03-18 2017-06-06 The Regents Of The University Of Colorado, A Body Corporate Ultrasensitive biochemical sensing device and method of sensing analytes
EP2718465B1 (en) 2011-06-09 2022-04-13 Illumina, Inc. Method of making an analyte array
AU2013246359B2 (en) * 2012-04-10 2017-03-30 The Trustees Of Princeton University Ultra-sensitive sensor
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
CN104487824A (zh) * 2012-07-29 2015-04-01 惠普发展公司，有限责任合伙企业 可植入的纳米传感器
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
CN103308462A (zh) * 2013-06-26 2013-09-18 南京邮电大学 银金核-卫星结构表面等离子体共振探针及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013063382A2 (en) * 2011-10-28 2013-05-02 Illumina, Inc. Microarray fabrication system and method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VENKATESAN BALA MURALI ET AL, "Nanopore sensors for nucleic acid analysis.", NATURE NANOTECHNOLOGY OCT 2011, (2011-10), vol. 6, no. 10, ISSN 1748-3395, pages 615 - 624 *

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