AU2014342593B2 - N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors - Google Patents

N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors Download PDF

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AU2014342593B2
AU2014342593B2 AU2014342593A AU2014342593A AU2014342593B2 AU 2014342593 B2 AU2014342593 B2 AU 2014342593B2 AU 2014342593 A AU2014342593 A AU 2014342593A AU 2014342593 A AU2014342593 A AU 2014342593A AU 2014342593 B2 AU2014342593 B2 AU 2014342593B2
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carboxamide
pyrrolidine
hydroxy
propan
pyrrolidin
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AU2014342593A1 (en
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Bing Wang
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Biomarin Pharmaceutical Inc
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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AU2014342593A 2013-10-29 2014-10-28 N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors Active AU2014342593B2 (en)

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US201361897110P 2013-10-29 2013-10-29
US61/897,110 2013-10-29
PCT/US2014/062516 WO2015065937A1 (en) 2013-10-29 2014-10-28 N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors

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US (2) US10239832B2 (enExample)
EP (1) EP3063141B1 (enExample)
JP (1) JP6526652B2 (enExample)
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AU (1) AU2014342593B2 (enExample)
CA (1) CA2927798C (enExample)
HR (1) HRP20181197T1 (enExample)
HU (1) HUE040220T2 (enExample)
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WO2021221953A1 (en) 2020-04-28 2021-11-04 The Regents Of The University Of Michigan Pyridine inhibitors of glucosylceramide synthase and therapeutic methods using the same
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JP2016535051A (ja) 2016-11-10
SI3063141T1 (sl) 2018-11-30
US20190276398A1 (en) 2019-09-12
AU2014342593A1 (en) 2016-05-05
US11358932B2 (en) 2022-06-14
SMT201800411T1 (it) 2018-09-13
IL245208B (en) 2020-09-30
CA2927798C (en) 2022-03-15
HUE040220T2 (hu) 2019-02-28
WO2015065937A1 (en) 2015-05-07
HRP20181197T1 (hr) 2018-11-30
TW201609635A (zh) 2016-03-16
US20160280643A1 (en) 2016-09-29
MX376685B (es) 2025-03-07
CN105849102B (zh) 2020-10-16
NZ719028A (en) 2021-12-24
TWI655185B (zh) 2019-04-01
IL245208A0 (en) 2016-06-30
EP3063141A1 (en) 2016-09-07
JP6526652B2 (ja) 2019-06-05
EP3063141B1 (en) 2018-02-28
CA2927798A1 (en) 2015-05-07
MX2016005437A (es) 2016-08-05
CN105849102A (zh) 2016-08-10
US10239832B2 (en) 2019-03-26

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