AU2014327233B2 - New 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors - Google Patents
New 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors Download PDFInfo
- Publication number
- AU2014327233B2 AU2014327233B2 AU2014327233A AU2014327233A AU2014327233B2 AU 2014327233 B2 AU2014327233 B2 AU 2014327233B2 AU 2014327233 A AU2014327233 A AU 2014327233A AU 2014327233 A AU2014327233 A AU 2014327233A AU 2014327233 B2 AU2014327233 B2 AU 2014327233B2
- Authority
- AU
- Australia
- Prior art keywords
- group
- hydrogen
- 4alkyl
- substituted
- 6alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- AFWBPNTWRKVDCI-UHFFFAOYSA-N CC1CCN(CCC(F)(F)F)CC1 Chemical compound CC1CCN(CCC(F)(F)F)CC1 AFWBPNTWRKVDCI-UHFFFAOYSA-N 0.000 description 2
- 0 *Cc1c(*)[n]c2c(*)c(*)nc(*)c12 Chemical compound *Cc1c(*)[n]c2c(*)c(*)nc(*)c12 0.000 description 1
- GDQMTDGUUOLIGK-UHFFFAOYSA-N Brc1ncc(c(C2CCNCC2)c[nH]2)c2c1 Chemical compound Brc1ncc(c(C2CCNCC2)c[nH]2)c2c1 GDQMTDGUUOLIGK-UHFFFAOYSA-N 0.000 description 1
- PYRCQIAYGFCXCA-UHFFFAOYSA-N CC(C)(CCc(c(c1c2)cnc2Br)c[n]1S(c1ccc(C)cc1)(=O)=O)O Chemical compound CC(C)(CCc(c(c1c2)cnc2Br)c[n]1S(c1ccc(C)cc1)(=O)=O)O PYRCQIAYGFCXCA-UHFFFAOYSA-N 0.000 description 1
- QZKWKIHWLGDMLP-UHFFFAOYSA-N CC(C1)(CN1C1CC1)F Chemical compound CC(C1)(CN1C1CC1)F QZKWKIHWLGDMLP-UHFFFAOYSA-N 0.000 description 1
- RKAXWSMSJHDUMV-UHFFFAOYSA-N CC(CC#N)c1c[nH]c2cc(Br)ncc12 Chemical compound CC(CC#N)c1c[nH]c2cc(Br)ncc12 RKAXWSMSJHDUMV-UHFFFAOYSA-N 0.000 description 1
- XQAKHSLZYFWGEU-UHFFFAOYSA-N CC1(C)CCN(CCCF)CC1 Chemical compound CC1(C)CCN(CCCF)CC1 XQAKHSLZYFWGEU-UHFFFAOYSA-N 0.000 description 1
- KFQQHGFHVVDLTL-UHFFFAOYSA-N CC1CCN(CCCF)CC1 Chemical compound CC1CCN(CCCF)CC1 KFQQHGFHVVDLTL-UHFFFAOYSA-N 0.000 description 1
- DHWXHYCQFFUPSD-UHFFFAOYSA-N CC1CCN(CCF)CC1 Chemical compound CC1CCN(CCF)CC1 DHWXHYCQFFUPSD-UHFFFAOYSA-N 0.000 description 1
- HTHUYXBZHCVPGU-UHFFFAOYSA-N CCCc1c[nH]c2cc(C)ncc12 Chemical compound CCCc1c[nH]c2cc(C)ncc12 HTHUYXBZHCVPGU-UHFFFAOYSA-N 0.000 description 1
- BPIJQXIQPHJMDO-UHFFFAOYSA-N Cc(cc1)ccc1S([n]1c(cc(nc2)Br)c2c(C2CCNCC2)c1)(=O)=O Chemical compound Cc(cc1)ccc1S([n]1c(cc(nc2)Br)c2c(C2CCNCC2)c1)(=O)=O BPIJQXIQPHJMDO-UHFFFAOYSA-N 0.000 description 1
- OVJXCAXFJTWWSX-UHFFFAOYSA-N FCCN1CCCCC1 Chemical compound FCCN1CCCCC1 OVJXCAXFJTWWSX-UHFFFAOYSA-N 0.000 description 1
- QRTBTMKDKYQNQK-UHFFFAOYSA-N NC(c(c(c1c2)cnc2Br)c[n]1-c1ccnc(N)n1)=O Chemical compound NC(c(c(c1c2)cnc2Br)c[n]1-c1ccnc(N)n1)=O QRTBTMKDKYQNQK-UHFFFAOYSA-N 0.000 description 1
- ZMTKXNUWQRIDLM-UHFFFAOYSA-N Nc1nccc(-[n]2c(cc(C#CC3(CCCC3)O)nc3)c3c(CCC#N)c2)n1 Chemical compound Nc1nccc(-[n]2c(cc(C#CC3(CCCC3)O)nc3)c3c(CCC#N)c2)n1 ZMTKXNUWQRIDLM-UHFFFAOYSA-N 0.000 description 1
- VGLKFQCLAWEYRD-UHFFFAOYSA-N Nc1nccc(-[n]2c3cc(Br)ncc3c(C3CCNCC3)c2)n1 Chemical compound Nc1nccc(-[n]2c3cc(Br)ncc3c(C3CCNCC3)c2)n1 VGLKFQCLAWEYRD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13186139 | 2013-09-26 | ||
| EP13186139.5 | 2013-09-26 | ||
| EP14176121 | 2014-07-08 | ||
| EP14176121.3 | 2014-07-08 | ||
| PCT/EP2014/070484 WO2015044267A1 (en) | 2013-09-26 | 2014-09-25 | NEW 1-(4-PYRIMIDINYL)-1H-PYRROLO[3,2-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014327233A1 AU2014327233A1 (en) | 2016-03-10 |
| AU2014327233B2 true AU2014327233B2 (en) | 2018-03-01 |
Family
ID=51619194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014327233A Ceased AU2014327233B2 (en) | 2013-09-26 | 2014-09-25 | New 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10005773B2 (enExample) |
| EP (1) | EP3071566B1 (enExample) |
| JP (1) | JP6402179B2 (enExample) |
| KR (1) | KR102317334B1 (enExample) |
| CN (1) | CN105579451B (enExample) |
| AU (1) | AU2014327233B2 (enExample) |
| BR (1) | BR112016005914A2 (enExample) |
| CA (1) | CA2922753C (enExample) |
| EA (1) | EA029595B1 (enExample) |
| ES (1) | ES2804595T3 (enExample) |
| IL (1) | IL244706B (enExample) |
| MX (1) | MX373186B (enExample) |
| TW (1) | TWI704146B (enExample) |
| WO (1) | WO2015044267A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| JP6616411B2 (ja) | 2014-10-23 | 2019-12-04 | ヤンセン ファーマシューティカ エヌ．ベー． | 新規な、ｎｉｋ阻害剤としてのピラゾール誘導体 |
| WO2016062792A1 (en) | 2014-10-23 | 2016-04-28 | Janssen Pharmaceutica Nv | New compounds as nik inhibitors |
| EA033237B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные пиразолопиримидина в качестве ингибиторов nik, фармацевтическая композиция и лекарственное средство, содержащее ее |
| AU2015334914B2 (en) | 2014-10-23 | 2019-09-19 | Janssen Pharmaceutica Nv | New thienopyrimidine derivatives as NIK inhibitors |
| HRP20200133T1 (hr) | 2016-01-22 | 2020-05-15 | Janssen Pharmaceutica Nv | Novi supstituirani derivati cijanoindolina kao inhibitori nik |
| EP3405464B1 (en) * | 2016-01-22 | 2019-12-04 | Janssen Pharmaceutica NV | New 6-membered heteroaromatic substituted cyanoindoline derivatives as nik inhibitors |
| EP3478675B1 (en) | 2016-06-30 | 2020-04-22 | Janssen Pharmaceutica NV | Heteroaromatic derivatives as nik inhibitors |
| WO2018002219A1 (en) | 2016-06-30 | 2018-01-04 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as nik inhibitors |
| JP7140751B2 (ja) * | 2016-08-24 | 2022-09-21 | エフ．ホフマン－ラ ロシュ アーゲー | ２－アザビシクロ［３．１．０］ヘキサン－３－オン誘導体及び使用方法 |
| CN109863142B (zh) * | 2016-08-24 | 2022-06-10 | 豪夫迈·罗氏有限公司 | 2-氮杂双环[3.1.0]己烷-3-酮衍生物及使用方法 |
| CR20210587A (es) | 2019-05-31 | 2022-02-11 | Janssen Pharmaceutica Nv | Inhibidores de molécula pequeña de quinasa inductora de nf-kb |
| CN113816957B (zh) * | 2021-10-29 | 2023-04-07 | 浙江工业大学 | 4-(7-氮杂吲哚)-2-氨基嘧啶类化合物及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009158011A1 (en) * | 2008-06-26 | 2009-12-30 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3990061B2 (ja) * | 1998-01-05 | 2007-10-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プリン誘導体および糖尿病の予防・治療剤としてのアデノシンａ２受容体拮抗剤 |
| BRPI0510319A (pt) | 2004-04-26 | 2007-10-16 | Pfizer | inibidores da enzima integrase de hiv |
| TW200736260A (en) * | 2005-11-10 | 2007-10-01 | Smithkline Beecham Corp | Inhibitors of Akt activity |
| DE102008005493A1 (de) | 2008-01-22 | 2009-07-23 | Merck Patent Gmbh | 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate |
| CA2728559A1 (en) * | 2008-07-03 | 2010-01-07 | Exelixis Inc. | Cdk modulators |
| WO2010042337A1 (en) | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
| WO2011050245A1 (en) * | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| AR085908A1 (es) | 2011-03-16 | 2013-11-06 | Hoffmann La Roche | DERIVADOS DE 3-BUTIN-2-OL Y DE CARBONITRILO CON ACTIVIDAD INHIBIDORA DE LA QUINASA INDUCTORA DE NF-kB (NIK) |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| AU2015334914B2 (en) | 2014-10-23 | 2019-09-19 | Janssen Pharmaceutica Nv | New thienopyrimidine derivatives as NIK inhibitors |
| JP6616411B2 (ja) | 2014-10-23 | 2019-12-04 | ヤンセン ファーマシューティカ エヌ．ベー． | 新規な、ｎｉｋ阻害剤としてのピラゾール誘導体 |
| WO2016062792A1 (en) | 2014-10-23 | 2016-04-28 | Janssen Pharmaceutica Nv | New compounds as nik inhibitors |
| EA033237B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные пиразолопиримидина в качестве ингибиторов nik, фармацевтическая композиция и лекарственное средство, содержащее ее |
-
2014
- 2014-09-24 TW TW103132898A patent/TWI704146B/zh not_active IP Right Cessation
- 2014-09-25 EA EA201690645A patent/EA029595B1/ru not_active IP Right Cessation
- 2014-09-25 US US15/024,603 patent/US10005773B2/en not_active Expired - Fee Related
- 2014-09-25 KR KR1020167007899A patent/KR102317334B1/ko not_active Expired - Fee Related
- 2014-09-25 AU AU2014327233A patent/AU2014327233B2/en not_active Ceased
- 2014-09-25 ES ES14772372T patent/ES2804595T3/es active Active
- 2014-09-25 CA CA2922753A patent/CA2922753C/en active Active
- 2014-09-25 EP EP14772372.0A patent/EP3071566B1/en active Active
- 2014-09-25 JP JP2016517332A patent/JP6402179B2/ja not_active Expired - Fee Related
- 2014-09-25 MX MX2016003861A patent/MX373186B/es active IP Right Grant
- 2014-09-25 WO PCT/EP2014/070484 patent/WO2015044267A1/en not_active Ceased
- 2014-09-25 BR BR112016005914A patent/BR112016005914A2/pt not_active Application Discontinuation
- 2014-09-25 CN CN201480052786.XA patent/CN105579451B/zh not_active Expired - Fee Related
-
2016
- 2016-03-22 IL IL244706A patent/IL244706B/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009158011A1 (en) * | 2008-06-26 | 2009-12-30 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| US10005773B2 (en) | 2018-06-26 |
| CN105579451A (zh) | 2016-05-11 |
| CA2922753C (en) | 2021-08-17 |
| EP3071566A1 (en) | 2016-09-28 |
| MX2016003861A (es) | 2016-07-26 |
| WO2015044267A1 (en) | 2015-04-02 |
| AU2014327233A1 (en) | 2016-03-10 |
| IL244706B (en) | 2021-02-28 |
| KR20160058814A (ko) | 2016-05-25 |
| CA2922753A1 (en) | 2015-04-02 |
| MX373186B (es) | 2020-05-12 |
| ES2804595T3 (es) | 2021-02-08 |
| EP3071566B1 (en) | 2020-04-15 |
| BR112016005914A2 (pt) | 2017-08-01 |
| EA029595B1 (ru) | 2018-04-30 |
| JP2016531868A (ja) | 2016-10-13 |
| TW201602104A (zh) | 2016-01-16 |
| KR102317334B1 (ko) | 2021-10-26 |
| US20160257679A1 (en) | 2016-09-08 |
| TWI704146B (zh) | 2020-09-11 |
| JP6402179B2 (ja) | 2018-10-10 |
| IL244706A0 (en) | 2016-04-21 |
| HK1224295A1 (zh) | 2017-08-18 |
| EA201690645A1 (ru) | 2016-08-31 |
| CN105579451B (zh) | 2017-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3071566B1 (en) | New 1-(4-pyrimidinyl)-1h-pyrrolo[3,2-c]pyridine derivatives as nik inhibitors | |
| AU2014259477B2 (en) | 3-(2-aminopyrimidin-4-yl)-5-(3-hydroxypropynyl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors for the treatment of cancer | |
| US10822342B2 (en) | Pyrazolopyrimidine derivatives as NIK inhibitors | |
| AU2014327235B2 (en) | New 3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors | |
| AU2015334914B2 (en) | New thienopyrimidine derivatives as NIK inhibitors | |
| AU2015334917A1 (en) | New compounds as NIK inhibitors | |
| EP3209654A1 (en) | New pyrazole derivatives as nik inhibitors | |
| HK1224295B (en) | New 1-(4-pyrimidinyl)-1 h-pyrrolo(3,2-c) pyridine derivatives as nik inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |