AU2014326257B2 - Compositions comprising heterogeneous populations of recombinant human clotting factor Xa proteins - Google Patents

Compositions comprising heterogeneous populations of recombinant human clotting factor Xa proteins Download PDF

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Publication number
AU2014326257B2
AU2014326257B2 AU2014326257A AU2014326257A AU2014326257B2 AU 2014326257 B2 AU2014326257 B2 AU 2014326257B2 AU 2014326257 A AU2014326257 A AU 2014326257A AU 2014326257 A AU2014326257 A AU 2014326257A AU 2014326257 B2 AU2014326257 B2 AU 2014326257B2
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AU
Australia
Prior art keywords
fxa variant
seq
protein
acid sequence
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014326257A
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English (en)
Other versions
AU2014326257A1 (en
Inventor
Michael Anthony JANKOWSKI
Keith A. Johnson
Wendy Carol PIACENZA
Jason C. ROUSE
Michael Shamashkin
Penelope Jane SHARPE
Mary Beth Switzer
Stacey B. WESTON
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Pfizer Inc
Original Assignee
Pfizer Inc
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Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of AU2014326257A1 publication Critical patent/AU2014326257A1/en
Application granted granted Critical
Publication of AU2014326257B2 publication Critical patent/AU2014326257B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Water Supply & Treatment (AREA)
  • Toxicology (AREA)
AU2014326257A 2013-09-24 2014-09-16 Compositions comprising heterogeneous populations of recombinant human clotting factor Xa proteins Ceased AU2014326257B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361881834P 2013-09-24 2013-09-24
US61/881,834 2013-09-24
PCT/IB2014/064564 WO2015044836A1 (en) 2013-09-24 2014-09-16 Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins

Publications (2)

Publication Number Publication Date
AU2014326257A1 AU2014326257A1 (en) 2016-03-10
AU2014326257B2 true AU2014326257B2 (en) 2017-08-10

Family

ID=51844797

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014326257A Ceased AU2014326257B2 (en) 2013-09-24 2014-09-16 Compositions comprising heterogeneous populations of recombinant human clotting factor Xa proteins

Country Status (19)

Country Link
US (3) US9757434B2 (https=)
EP (1) EP3049434A1 (https=)
JP (1) JP6429885B2 (https=)
KR (1) KR101988705B1 (https=)
CN (2) CN112195169A (https=)
AR (1) AR097732A1 (https=)
AU (1) AU2014326257B2 (https=)
BR (1) BR112016005899A8 (https=)
CA (1) CA2924981C (https=)
HK (1) HK1218760A1 (https=)
IL (2) IL244258A0 (https=)
MX (1) MX373466B (https=)
MY (1) MY173548A (https=)
PE (1) PE20160877A1 (https=)
RU (1) RU2648144C2 (https=)
SA (1) SA516370751B1 (https=)
SG (1) SG11201601221XA (https=)
TW (1) TWI631134B (https=)
WO (1) WO2015044836A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2761730T3 (es) 2013-01-31 2020-05-20 Pfizer Composiciones y procedimientos para contrarrestar la inhibición del factor Xa
EP3049434A1 (en) 2013-09-24 2016-08-03 Pfizer Inc. Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins
PT3472314T (pt) * 2016-06-17 2021-06-18 Alexion Pharma Inc Preparação de derivados do fator xa
EP3722418A1 (en) * 2019-04-08 2020-10-14 AB Enzymes Oy Solution stable enzyme composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090175931A1 (en) * 2005-11-15 2009-07-09 Camire Rodney M Compositions and methods for modulating hemostasis
WO2013049804A1 (en) * 2011-09-30 2013-04-04 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US5597799A (en) 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
AT405517B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
AT405516B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
AT410216B (de) 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
AU2001249389A1 (en) 2000-03-22 2001-10-03 The Children's Hospital Of Philadelphia Modified blood clotting factors and methods of use
FR2831170B1 (fr) 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
FR2841904B1 (fr) 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
WO2006018204A1 (en) 2004-08-17 2006-02-23 Zlb Behring Gmbh Modified vitamin k dependent polypeptides
EP1728798A1 (en) 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
EP1820508A1 (en) 2006-02-21 2007-08-22 CSL Behring GmbH Coagulation factor X polypeptides with modified activation properties
EP2915564B1 (en) * 2007-09-28 2020-11-04 Portola Pharmaceuticals, Inc. Antidotes for factor XA inhibitors and methods of using the same
EP2300497B1 (en) 2008-06-24 2012-08-08 Octapharma AG A process of purifying coagulation factor viii
MX2011004907A (es) * 2008-11-14 2011-07-29 Portola Pharm Inc Antidotos para inhibidores del factor xa y metodos para el uso de los mismos en combinacion con agentes de coagulacion de sangre.
JP5833448B2 (ja) 2008-12-19 2015-12-16 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル セリンプロテアーゼ誘導体および血液凝固疾患の予防または処置における使用
ES2605801T3 (es) 2009-07-15 2017-03-16 Portola Pharmaceuticals, Inc. Formulación de dosis unitaria de antídoto para inhibidores del factor Xa para su uso en la prevención de la hemorragia
TW201217527A (en) * 2010-07-09 2012-05-01 Biogen Idec Hemophilia Inc Processable single chain molecules and polypeptides made using same
FR2972114B1 (fr) 2011-03-01 2013-03-15 Univ Grenoble 1 Un nouveau leurre moleculaire procoagulant pour le traitement des hemophiles a ou b avec ou sans inhibiteur
WO2014018120A1 (en) 2012-07-25 2014-01-30 Catalyst Biosciences, Inc. Modified factor x polypeptides and uses thereof
ES2761730T3 (es) 2013-01-31 2020-05-20 Pfizer Composiciones y procedimientos para contrarrestar la inhibición del factor Xa
EP3049434A1 (en) 2013-09-24 2016-08-03 Pfizer Inc. Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins
EP3063170A4 (en) 2013-11-01 2017-06-28 The Children's Hospital of Philadelphia Compositions and methods for increasing the half-life of factor xa
BR112016014617A2 (pt) 2014-01-24 2017-09-19 Pfizer Variante do fator xa (fxa) e usos da referida variante

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090175931A1 (en) * 2005-11-15 2009-07-09 Camire Rodney M Compositions and methods for modulating hemostasis
WO2013049804A1 (en) * 2011-09-30 2013-04-04 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUNCE, M.W. et al.: "Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro", BLOOD (2011), Vol.117 No.1 pg290-298 *
IVANCIU, L. et al.: "A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia", NATURE BIOTECHNOLOGY (2011), Vol. 29 No.11 pages 1028-1033 *
YAN-MEI SUN, et al.: "Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X", BLOOD (2005), Vol.106 No.12 pg 3811-3815 *

Also Published As

Publication number Publication date
RU2016108608A (ru) 2017-10-26
JP6429885B2 (ja) 2018-11-28
WO2015044836A1 (en) 2015-04-02
KR20160044034A (ko) 2016-04-22
US20210106658A1 (en) 2021-04-15
BR112016005899A8 (pt) 2018-02-06
AU2014326257A1 (en) 2016-03-10
TWI631134B (zh) 2018-08-01
MY173548A (en) 2020-02-04
SA516370751B1 (ar) 2018-04-05
US20150182604A1 (en) 2015-07-02
IL279396A (en) 2021-01-31
MX373466B (es) 2020-05-25
TW201524996A (zh) 2015-07-01
HK1218760A1 (zh) 2017-03-10
PE20160877A1 (es) 2016-09-11
US10660946B2 (en) 2020-05-26
US9757434B2 (en) 2017-09-12
CN105579468A (zh) 2016-05-11
EP3049434A1 (en) 2016-08-03
US20170333535A1 (en) 2017-11-23
MX2016003871A (es) 2016-08-04
SG11201601221XA (en) 2016-04-28
CN112195169A (zh) 2021-01-08
BR112016005899A2 (pt) 2017-09-26
JP2016535071A (ja) 2016-11-10
RU2648144C2 (ru) 2018-03-22
CA2924981A1 (en) 2015-04-02
KR101988705B1 (ko) 2019-06-12
IL244258A0 (en) 2016-04-21
AR097732A1 (es) 2016-04-13
CA2924981C (en) 2020-03-31

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired