AU2014318924A1 - Atrasentan mandelate salts for the treatement of kidney diseases - Google Patents
Atrasentan mandelate salts for the treatement of kidney diseases Download PDFInfo
- Publication number
- AU2014318924A1 AU2014318924A1 AU2014318924A AU2014318924A AU2014318924A1 AU 2014318924 A1 AU2014318924 A1 AU 2014318924A1 AU 2014318924 A AU2014318924 A AU 2014318924A AU 2014318924 A AU2014318924 A AU 2014318924A AU 2014318924 A1 AU2014318924 A1 AU 2014318924A1
- Authority
- AU
- Australia
- Prior art keywords
- salt
- atrasentan
- mandelate
- mandelate salt
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- -1 Atrasentan mandelate salts Chemical class 0.000 title claims abstract description 209
- 208000017169 kidney disease Diseases 0.000 title claims abstract description 12
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
- C07C59/50—Mandelic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361877101P | 2013-09-12 | 2013-09-12 | |
| US61/877,101 | 2013-09-12 | ||
| US14/133,297 US8962675B1 (en) | 2013-09-12 | 2013-12-18 | Atrasentan mandelate salts |
| US14/133,297 | 2013-12-18 | ||
| PCT/US2014/054888 WO2015038571A1 (en) | 2013-09-12 | 2014-09-10 | Atrasentan mandelate salts for the treatement of kidney diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2014318924A1 true AU2014318924A1 (en) | 2016-03-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014318924A Abandoned AU2014318924A1 (en) | 2013-09-12 | 2014-09-10 | Atrasentan mandelate salts for the treatement of kidney diseases |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8962675B1 (enExample) |
| EP (2) | EP3044222B1 (enExample) |
| JP (1) | JP2016530311A (enExample) |
| CN (1) | CN105745204A (enExample) |
| AU (1) | AU2014318924A1 (enExample) |
| CA (1) | CA2923627C (enExample) |
| CL (1) | CL2016000583A1 (enExample) |
| MX (1) | MX2016003065A (enExample) |
| WO (1) | WO2015038571A1 (enExample) |
Families Citing this family (6)
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| RU2016103764A (ru) * | 2013-07-08 | 2017-08-11 | Эббви Инк. | Стабилизированные фармацевтические лекарственные формы, содержащие атрасентан |
| CN105905245B (zh) * | 2016-06-03 | 2018-12-25 | 青岛北海船舶重工有限责任公司 | 用于水面无人艇布放回收的吊笼 |
| CN116173014A (zh) | 2019-12-17 | 2023-05-30 | 奇努克医疗公司 | 用阿曲生坦治疗IgA肾病的方法 |
| US20220304979A1 (en) * | 2019-12-17 | 2022-09-29 | Chinook Therapeutics, Inc. | Methods of reducing disease flares |
| CR20230083A (es) | 2020-07-10 | 2023-05-16 | Astrazeneca Ab | Combinación de zibotentan y dapagliflozina para el tratamiento de la enfermedad renal crónica |
| CN120302971A (zh) | 2022-10-28 | 2025-07-11 | 奇努克治疗公司 | 使用内皮素受体拮抗剂和april结合抗体治疗iga肾病 |
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| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US7208517B1 (en) * | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
| US6946481B1 (en) | 1994-08-19 | 2005-09-20 | Abbott Laboratories | Endothelin antagonists |
| US7365093B2 (en) | 1994-08-19 | 2008-04-29 | Abbott Laboratories | Endothelin antagonists |
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| DE69527072T2 (de) * | 1994-08-19 | 2003-02-13 | Abbott Laboratories, Abbott Park | Endothelin antagoniste |
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| US5801250A (en) | 1996-12-13 | 1998-09-01 | Abbott Laboratories | Process for the stereoselective production of nitro-enamine compounds |
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| US20020055457A1 (en) | 2000-08-07 | 2002-05-09 | Janus Todd J. | Methods of treating cancer and the pain associated therewith using endothelin antagonists |
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| US20030022811A1 (en) | 2001-04-11 | 2003-01-30 | Amitabh Singh | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
| US20030092757A1 (en) | 2001-04-11 | 2003-05-15 | Amitabh Singh | Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer |
| UA79248C2 (en) * | 2001-11-09 | 2007-06-11 | Janssen Pharmaceutica Nv | Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives |
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| US20060189675A1 (en) | 2004-09-17 | 2006-08-24 | Steve King | Crystalline form of a drug |
| US20060135596A1 (en) * | 2004-09-17 | 2006-06-22 | Zhang Geoff G | Amorphous form of a drug |
| US20060063825A1 (en) * | 2004-09-17 | 2006-03-23 | Walter Dziki | Crystalline form of a drug |
| US20080132710A1 (en) | 2006-12-04 | 2008-06-05 | Abbott Laboratories | Atrasentan hydrochloride crystalline form 2 |
| EP2294047A2 (en) * | 2008-04-04 | 2011-03-16 | Actavis Group PTC EHF | Novel mandelate salt of fesoterodine |
| US20100184026A1 (en) | 2009-01-22 | 2010-07-22 | Abbott Laboratories | Companion Diagnostic Assays For Endothelin Receptor Antagonists |
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| MX2016003065A (es) | 2016-05-26 |
| EP3044222B1 (en) | 2017-07-05 |
| WO2015038571A1 (en) | 2015-03-19 |
| US8962675B1 (en) | 2015-02-24 |
| EP3239148A1 (en) | 2017-11-01 |
| CL2016000583A1 (es) | 2016-11-11 |
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