AU2014288857B2 - A pharmaceutical combination for the treatment of melanoma - Google Patents

A pharmaceutical combination for the treatment of melanoma Download PDF

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Publication number
AU2014288857B2
AU2014288857B2 AU2014288857A AU2014288857A AU2014288857B2 AU 2014288857 B2 AU2014288857 B2 AU 2014288857B2 AU 2014288857 A AU2014288857 A AU 2014288857A AU 2014288857 A AU2014288857 A AU 2014288857A AU 2014288857 B2 AU2014288857 B2 AU 2014288857B2
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AU
Australia
Prior art keywords
melanoma
inhibitor
compound
braf
vemurafenib
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AU2014288857A
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English (en)
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AU2014288857A1 (en
Inventor
Veena Agarwal
Giridharan Periyasamy
Maggie Rathos
Sreesha SRINIVASA
Ankita SRIVASTAVA
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Piramal Enterprises Ltd
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Piramal Enterprises Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2014288857A 2013-07-12 2014-07-11 A pharmaceutical combination for the treatment of melanoma Active AU2014288857B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361845749P 2013-07-12 2013-07-12
US61/845,749 2013-07-12
PCT/IB2014/063022 WO2015004636A1 (en) 2013-07-12 2014-07-11 A pharmaceutical combination for the treatment of melanoma

Publications (2)

Publication Number Publication Date
AU2014288857A1 AU2014288857A1 (en) 2016-02-04
AU2014288857B2 true AU2014288857B2 (en) 2019-03-14

Family

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Application Number Title Priority Date Filing Date
AU2014288857A Active AU2014288857B2 (en) 2013-07-12 2014-07-11 A pharmaceutical combination for the treatment of melanoma

Country Status (12)

Country Link
US (4) US11007174B2 (https=)
EP (1) EP3019166B1 (https=)
JP (5) JP6568060B2 (https=)
CN (3) CN111053768B (https=)
AR (1) AR096892A1 (https=)
AU (1) AU2014288857B2 (https=)
CA (1) CA2917742C (https=)
DK (1) DK3019166T3 (https=)
ES (1) ES2733929T3 (https=)
IL (1) IL243572B (https=)
TW (4) TW202031253A (https=)
WO (1) WO2015004636A1 (https=)

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US10821112B2 (en) * 2016-03-16 2020-11-03 Dicerna Pharmaceuticals, Inc. Compositions and methods for the treatment of a beta-catenin-associated disease or disorder
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EP3624896A4 (en) * 2017-05-16 2021-03-31 Biomed Valley Discoveries, Inc. COMPOSITIONS AND METHODS OF TREATMENT OF CANCER WITH ATYPICAL BRAF MUTATIONS
AU2018368453B2 (en) 2017-11-17 2024-05-30 The Board Of Trustees Of The University Of Illinois Cancer therapy by degrading dual MEK signaling
CN107827726B (zh) * 2017-11-28 2020-09-15 辽宁中医药大学 马齿苋中化合物Oleracone E及其提取分离方法
CN108591464B (zh) * 2018-06-28 2020-06-23 宁波奥克斯高科技有限公司 一种气体绝缘开关柜用密封结构
CA3114385A1 (en) * 2018-10-05 2020-04-09 The Board Of Trustees Of The University Of Illinois Combination therapy for the treatment of uveal melanoma
MX2021012248A (es) * 2019-04-11 2022-03-11 Mei Pharma Inc Polimorfos de voruciclib y metodos de elaboracion y uso de los mismos.
US20240000789A1 (en) * 2020-05-12 2024-01-04 Novartis Ag Therapeutic combinations comprising a craf inhibitor
CN112168821B (zh) * 2020-11-09 2022-10-14 中南大学湘雅医院 一种治疗维罗非尼耐药的黑色素瘤的联合用药物及其应用
MX2023005806A (es) * 2020-11-19 2023-07-31 Mei Pharma Inc Tratamiento de cánceres con mutación en oncogen homologo al virus kirsten de sarcoma de rata (kras).
CN117043159A (zh) * 2020-11-19 2023-11-10 梅制药公司 Kras突变型癌症的治疗

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Also Published As

Publication number Publication date
WO2015004636A1 (en) 2015-01-15
CN105530931B (zh) 2019-11-08
JP7799508B2 (ja) 2026-01-15
TW201534297A (zh) 2015-09-16
JP2022068335A (ja) 2022-05-09
US20160136132A1 (en) 2016-05-19
ES2733929T3 (es) 2019-12-03
TW202031253A (zh) 2020-09-01
US20190282544A1 (en) 2019-09-19
TW202233177A (zh) 2022-09-01
IL243572B (en) 2019-10-31
CN117731786A (zh) 2024-03-22
JP2024037891A (ja) 2024-03-19
JP2021001186A (ja) 2021-01-07
EP3019166B1 (en) 2019-05-08
DK3019166T3 (da) 2019-07-29
US20210393589A1 (en) 2021-12-23
JP2016525097A (ja) 2016-08-22
JP2019206565A (ja) 2019-12-05
TWI839690B (zh) 2024-04-21
CN105530931A (zh) 2016-04-27
US11007174B2 (en) 2021-05-18
TW202502325A (zh) 2025-01-16
US11839591B2 (en) 2023-12-12
CA2917742A1 (en) 2015-01-15
IL243572A0 (en) 2016-02-29
CA2917742C (en) 2020-04-14
EP3019166A4 (en) 2017-04-19
AU2014288857A1 (en) 2016-02-04
TWI680760B (zh) 2020-01-01
CN111053768B (zh) 2023-12-12
US12383530B2 (en) 2025-08-12
EP3019166A1 (en) 2016-05-18
US20240165076A1 (en) 2024-05-23
AR096892A1 (es) 2016-02-03
JP6568060B2 (ja) 2019-08-28
CN111053768A (zh) 2020-04-24

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