AU2014252807A1 - The local treatment of inflammatory ophthalmic diseases - Google Patents

The local treatment of inflammatory ophthalmic diseases Download PDF

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Publication number
AU2014252807A1
AU2014252807A1 AU2014252807A AU2014252807A AU2014252807A1 AU 2014252807 A1 AU2014252807 A1 AU 2014252807A1 AU 2014252807 A AU2014252807 A AU 2014252807A AU 2014252807 A AU2014252807 A AU 2014252807A AU 2014252807 A1 AU2014252807 A1 AU 2014252807A1
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AU
Australia
Prior art keywords
compound
alkyl
use according
nalidixic acid
cycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2014252807A
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English (en)
Inventor
Alan Leslie Rothaul
Robert Arthur SCOFFIN
Jeremy Gilbert Vinter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cresset Biomolecular Discovery Ltd
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Cresset Biomolecular Discovery Ltd
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Priority claimed from GB201306413A external-priority patent/GB201306413D0/en
Priority claimed from GB201306411A external-priority patent/GB201306411D0/en
Application filed by Cresset Biomolecular Discovery Ltd filed Critical Cresset Biomolecular Discovery Ltd
Publication of AU2014252807A1 publication Critical patent/AU2014252807A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/473Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
AU2014252807A 2013-04-09 2014-04-09 The local treatment of inflammatory ophthalmic diseases Abandoned AU2014252807A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1306413.4 2013-04-09
GB201306413A GB201306413D0 (en) 2013-04-09 2013-04-09 The local treatment of ophthalmic diseases
GB1306411.8 2013-04-09
GB201306411A GB201306411D0 (en) 2013-04-09 2013-04-09 Treatment of inflammatory conditions
PCT/GB2014/051108 WO2014167326A1 (en) 2013-04-09 2014-04-09 The local treatment of inflammatory ophthalmic diseases

Publications (1)

Publication Number Publication Date
AU2014252807A1 true AU2014252807A1 (en) 2015-11-12

Family

ID=50489339

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2014252807A Abandoned AU2014252807A1 (en) 2013-04-09 2014-04-09 The local treatment of inflammatory ophthalmic diseases
AU2014252808A Abandoned AU2014252808A1 (en) 2013-04-09 2014-04-09 The treatment of inflammatory disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2014252808A Abandoned AU2014252808A1 (en) 2013-04-09 2014-04-09 The treatment of inflammatory disorders

Country Status (11)

Country Link
US (2) US20160051526A1 (enExample)
EP (2) EP2983713A1 (enExample)
JP (2) JP2016516761A (enExample)
CN (2) CN105431172A (enExample)
AU (2) AU2014252807A1 (enExample)
CA (2) CA2909117A1 (enExample)
GB (2) GB2516137B (enExample)
HK (2) HK1221190A1 (enExample)
RU (2) RU2015145134A (enExample)
WO (2) WO2014167327A1 (enExample)
ZA (2) ZA201507718B (enExample)

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CN108348516B (zh) * 2015-10-29 2021-02-12 特一华制药株式会社 外用剂
AU2017336765B2 (en) 2016-09-28 2023-06-08 Medicon Pharmaceuticals, Inc. Compositions and methods for treating ophthalmic conditions
WO2020021035A1 (en) * 2018-07-26 2020-01-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of antibiotics for the treatment of immunoglobulin a nephropathy
EP3921309A1 (en) * 2019-02-08 2021-12-15 Frequency Therapeutics, Inc. Quinolin-4-one and 4(1h)-cinnolinone compounds and methods of using same
WO2021050649A1 (en) * 2019-09-11 2021-03-18 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept

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RU2015145134A3 (enExample) 2018-03-16
GB2516138A (en) 2015-01-14
HK1221166A1 (zh) 2017-05-26
GB201406390D0 (en) 2014-05-21
RU2015145135A (ru) 2017-05-12
WO2014167327A1 (en) 2014-10-16
CA2909111A1 (en) 2014-10-16
US20160051526A1 (en) 2016-02-25
JP2016516762A (ja) 2016-06-09
ZA201507724B (en) 2019-02-27
CN105555364A (zh) 2016-05-04
CA2909117A1 (en) 2014-10-16
GB2516138B (en) 2015-11-25
HK1221190A1 (zh) 2017-05-26
EP2983713A1 (en) 2016-02-17
JP2016516761A (ja) 2016-06-09
EP2983788A1 (en) 2016-02-17
RU2015145134A (ru) 2017-05-16
US20160068527A1 (en) 2016-03-10
AU2014252808A1 (en) 2015-11-12
CN105431172A (zh) 2016-03-23
GB2516138C (en) 2015-12-09
ZA201507718B (en) 2019-11-27
GB2516137A (en) 2015-01-14
WO2014167326A1 (en) 2014-10-16
GB2516137B (en) 2016-02-17
GB201406396D0 (en) 2014-05-21

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