AU2014244053B2 - Treatment of a diastolic cardiac dysfunction with a TRPV2 receptor agonist - Google Patents

Treatment of a diastolic cardiac dysfunction with a TRPV2 receptor agonist Download PDF

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Publication number
AU2014244053B2
AU2014244053B2 AU2014244053A AU2014244053A AU2014244053B2 AU 2014244053 B2 AU2014244053 B2 AU 2014244053B2 AU 2014244053 A AU2014244053 A AU 2014244053A AU 2014244053 A AU2014244053 A AU 2014244053A AU 2014244053 B2 AU2014244053 B2 AU 2014244053B2
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Prior art keywords
probenecid
trpv2
receptor agonist
subject
dose
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AU2014244053A
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AU2014244053A1 (en
Inventor
Keith W. Jones
Jack RUBINSTEIN
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University of Cincinnati
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University of Cincinnati
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2014244053A 2013-03-13 2014-03-13 Treatment of a diastolic cardiac dysfunction with a TRPV2 receptor agonist Active AU2014244053B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361778826P 2013-03-13 2013-03-13
US61/778,826 2013-03-13
PCT/US2014/025930 WO2014160153A1 (en) 2013-03-13 2014-03-13 Treatment of a diastolic cardiac dysfunction with a trpv2 receptor agonist

Publications (2)

Publication Number Publication Date
AU2014244053A1 AU2014244053A1 (en) 2015-09-24
AU2014244053B2 true AU2014244053B2 (en) 2018-08-30

Family

ID=50680137

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014244053A Active AU2014244053B2 (en) 2013-03-13 2014-03-13 Treatment of a diastolic cardiac dysfunction with a TRPV2 receptor agonist

Country Status (7)

Country Link
US (1) US10583103B2 (enExample)
EP (1) EP2968238A1 (enExample)
JP (3) JP2016512564A (enExample)
AU (1) AU2014244053B2 (enExample)
CA (1) CA2904671C (enExample)
MX (1) MX376077B (enExample)
WO (1) WO2014160153A1 (enExample)

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US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
EP3563859B1 (en) 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Cardiosphere-derived exosomes for tissue regeneration
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
EP3402543B1 (en) * 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
EP3612191B1 (en) 2017-04-19 2026-03-11 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
AU2018384096B2 (en) * 2017-12-12 2021-04-15 Cardiol Therapeutics Inc. Amphiphilic block copolymers, micelles, and methods for treating or preventing heart failure
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
US12642806B2 (en) 2019-10-25 2026-06-02 Cardiol Therapeutics Inc. Cannabidiol compositions for use in treating heart conditions
EP4106870A4 (en) * 2020-02-19 2024-04-10 Merchant, Shreema Compositions and therapeutic uses of cannabidiol
KR20210150011A (ko) * 2020-06-03 2021-12-10 주식회사 삼오파마켐 프로베네시드 및 아르기닌의 아미드 유도체, 이를 포함하는 약제학적 조성물 및 이의 제조 방법
CN113861633B (zh) * 2021-10-14 2022-12-20 武汉工程大学 一种p-n-b阻燃pbs塑料及其制备方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20130046021A1 (en) * 2011-08-12 2013-02-21 University Of Cincinnati Methods of treating cardiomyopathy, systolic cardiac dysfunction and the symptoms of congestive heart failure with probenecid

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JPH01211582A (ja) 1988-02-16 1989-08-24 Tanabe Seiyaku Co Ltd ベンゾジオキソール誘導体
CA2115442C (en) 1991-09-09 2003-09-23 Christopher Franklin Bigge Pharmaceutical preparation containing an uricosuric agent and an excitatory amino acid antagonist
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Also Published As

Publication number Publication date
US20160008305A1 (en) 2016-01-14
CA2904671C (en) 2022-08-30
US10583103B2 (en) 2020-03-10
MX2015012547A (es) 2016-02-10
CA2904671A1 (en) 2014-10-02
EP2968238A1 (en) 2016-01-20
JP2021042248A (ja) 2021-03-18
MX376077B (es) 2025-03-07
JP2024009140A (ja) 2024-01-19
JP2016512564A (ja) 2016-04-28
WO2014160153A1 (en) 2014-10-02
AU2014244053A1 (en) 2015-09-24

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