AU2014231229A1 - Single high dose of MVA induces a protective immune response in neonates and infants - Google Patents

Single high dose of MVA induces a protective immune response in neonates and infants Download PDF

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Publication number
AU2014231229A1
AU2014231229A1 AU2014231229A AU2014231229A AU2014231229A1 AU 2014231229 A1 AU2014231229 A1 AU 2014231229A1 AU 2014231229 A AU2014231229 A AU 2014231229A AU 2014231229 A AU2014231229 A AU 2014231229A AU 2014231229 A1 AU2014231229 A1 AU 2014231229A1
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AU
Australia
Prior art keywords
mva
administration
tcid
human
mice
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Abandoned
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AU2014231229A
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English (en)
Inventor
Paul Chaplin
Cedric Cheminay
Mark Suter
Ariane Volkmann
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Bavarian Nordic AS
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Bavarian Nordic AS
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Publication of AU2014231229A1 publication Critical patent/AU2014231229A1/en
Priority to AU2019200977A priority Critical patent/AU2019200977A1/en
Priority to AU2020260472A priority patent/AU2020260472A1/en
Priority to AU2022235527A priority patent/AU2022235527B2/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165Mumps or measles virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/275Poxviridae, e.g. avipoxvirus
    • A61K39/285Vaccinia virus or variola virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24041Use of virus, viral particle or viral elements as a vector
    • C12N2710/24043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18411Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AU2014231229A 2013-03-15 2014-03-14 Single high dose of MVA induces a protective immune response in neonates and infants Abandoned AU2014231229A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2019200977A AU2019200977A1 (en) 2013-03-15 2019-02-12 Single high dose of mva induces a protective immune response in neonates and infants
AU2020260472A AU2020260472A1 (en) 2013-03-15 2020-10-29 Single high dose of mva induces a protective immune response in neonates and infants
AU2022235527A AU2022235527B2 (en) 2013-03-15 2022-09-20 Single high dose of mva induces a protective immune response in neonates and infants

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361788722P 2013-03-15 2013-03-15
US61/788,722 2013-03-15
PCT/EP2014/000693 WO2014139687A1 (en) 2013-03-15 2014-03-14 Single high dose of mva induces a protective immune response in neonates and infants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019200977A Division AU2019200977A1 (en) 2013-03-15 2019-02-12 Single high dose of mva induces a protective immune response in neonates and infants

Publications (1)

Publication Number Publication Date
AU2014231229A1 true AU2014231229A1 (en) 2015-09-17

Family

ID=50389388

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2014231229A Abandoned AU2014231229A1 (en) 2013-03-15 2014-03-14 Single high dose of MVA induces a protective immune response in neonates and infants
AU2019200977A Abandoned AU2019200977A1 (en) 2013-03-15 2019-02-12 Single high dose of mva induces a protective immune response in neonates and infants
AU2020260472A Abandoned AU2020260472A1 (en) 2013-03-15 2020-10-29 Single high dose of mva induces a protective immune response in neonates and infants
AU2022235527A Active AU2022235527B2 (en) 2013-03-15 2022-09-20 Single high dose of mva induces a protective immune response in neonates and infants

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2019200977A Abandoned AU2019200977A1 (en) 2013-03-15 2019-02-12 Single high dose of mva induces a protective immune response in neonates and infants
AU2020260472A Abandoned AU2020260472A1 (en) 2013-03-15 2020-10-29 Single high dose of mva induces a protective immune response in neonates and infants
AU2022235527A Active AU2022235527B2 (en) 2013-03-15 2022-09-20 Single high dose of mva induces a protective immune response in neonates and infants

Country Status (17)

Country Link
US (1) US9707291B2 (https=)
EP (2) EP2968524A1 (https=)
JP (1) JP6480875B2 (https=)
KR (1) KR102269491B1 (https=)
CN (1) CN105101993A (https=)
AU (4) AU2014231229A1 (https=)
BR (1) BR112015021781A2 (https=)
CA (1) CA2905569C (https=)
EA (1) EA034825B1 (https=)
HK (1) HK1216860A1 (https=)
IL (1) IL241059B (https=)
MX (1) MX376293B (https=)
MY (1) MY175269A (https=)
SG (2) SG11201507192SA (https=)
UA (1) UA126785C2 (https=)
WO (1) WO2014139687A1 (https=)
ZA (1) ZA201507017B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102269491B1 (ko) * 2013-03-15 2021-06-25 버베리안 노딕 에이/에스 단회 고용량의 mva가 신생아 및 영아에서 보호 면역 반응을 유도
US10653766B2 (en) 2014-03-12 2020-05-19 Bavarian Nordic A/S Use of oil and water emulsions for increasing B cell responses with modified Vaccinia Ankara virus
EP4164682A1 (en) * 2020-06-10 2023-04-19 Bavarian Nordic A/S A recombinant modified vaccinia virus ankara (mva) vaccine against coronavirus disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9117596D0 (en) * 1991-08-15 1991-10-02 John Gibson Lifting Gear Ltd Pulling system
US5471902A (en) * 1994-02-22 1995-12-05 Athenry Enterprises Limited Tuning system for pianos
US7628980B2 (en) * 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7097842B2 (en) * 2000-11-23 2006-08-29 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7445924B2 (en) * 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
UA76731C2 (uk) * 2000-11-23 2006-09-15 Баваріан Нордік А/С Штам mva-bn модифікованого вірусу коров'ячої віспи ankara, фармацевтична композиція, вакцина, застосування mva-bn для приготування лікарського препарату та для приготування вакцини, спосіб введення гомологічної і/або гетерологічної послідовності нуклеїнової кислоти в клітини-мішені in vitro, спосіб одержання пептиду або білка, спосіб одержання mva-bn, клітина, набір для основної/бустерної імунізації
CN100540051C (zh) * 2002-04-19 2009-09-16 巴法里安诺迪克有限公司 用于接种新生儿的改良的安卡拉痘苗病毒
US7501127B2 (en) * 2002-05-16 2009-03-10 Bavarian Nordic A/S Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara
UA100836C2 (ru) * 2005-02-23 2013-02-11 Бавариан Нордик А/С Применение модифицированного вируса осповакцины анкара (mva) для быстрой индукции иммунитета против поксвирусных или других инфекционных агентов
EP2064351A1 (en) * 2006-09-08 2009-06-03 Bavarian Nordic A/S Phenotypic and genotypic differences of mva strains
EP2303322A1 (en) * 2008-06-20 2011-04-06 Bavarian Nordic A/S Recombinant modified vaccinia virus measles vaccine
AU2010305030A1 (en) * 2009-10-08 2012-05-10 Bavarian Nordic A/S Generation of a broad T-cell response in humans against HIV
US9463238B2 (en) * 2011-12-09 2016-10-11 Bavarian Nordic A/S Recombinant poxvirus vector comprising tetanus toxin fragment C
WO2013189611A1 (en) * 2012-06-22 2013-12-27 Bavarian Nordic A/S Poxviral vectors for low antibody response after a first priming immunization
KR102435054B1 (ko) * 2012-08-01 2022-08-22 버베리안 노딕 에이/에스 재조합 변형된 백시니아 바이러스 앙카라(ankara) (mva) 호흡기 신시티알 바이러스(rsv) 백신
KR102269491B1 (ko) * 2013-03-15 2021-06-25 버베리안 노딕 에이/에스 단회 고용량의 mva가 신생아 및 영아에서 보호 면역 반응을 유도

Also Published As

Publication number Publication date
IL241059A0 (en) 2015-11-30
MX376293B (es) 2025-03-07
MX2015011388A (es) 2016-02-03
JP6480875B2 (ja) 2019-03-13
EA034825B1 (ru) 2020-03-25
AU2019200977A1 (en) 2019-02-28
CA2905569A1 (en) 2014-09-18
JP2016514114A (ja) 2016-05-19
CA2905569C (en) 2023-07-25
IL241059B (en) 2020-10-29
SG11201507192SA (en) 2015-10-29
KR20150129027A (ko) 2015-11-18
HK1216860A1 (zh) 2016-12-09
CN105101993A (zh) 2015-11-25
US20160030551A1 (en) 2016-02-04
NZ711569A (en) 2021-03-26
SG10201707340XA (en) 2017-10-30
MY175269A (en) 2020-06-17
ZA201507017B (en) 2018-12-19
EA201591803A1 (ru) 2016-02-29
WO2014139687A1 (en) 2014-09-18
AU2022235527B2 (en) 2023-10-26
EP2968524A1 (en) 2016-01-20
UA126785C2 (uk) 2023-02-08
EP3708187A1 (en) 2020-09-16
US9707291B2 (en) 2017-07-18
AU2022235527A1 (en) 2022-10-13
AU2020260472A1 (en) 2020-11-26
KR102269491B1 (ko) 2021-06-25
BR112015021781A2 (pt) 2017-07-18

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