AU2014229638B2 - Methods for the synthesis of sphingomyelins and dihydrosphingomyelins - Google Patents
Methods for the synthesis of sphingomyelins and dihydrosphingomyelins Download PDFInfo
- Publication number
- AU2014229638B2 AU2014229638B2 AU2014229638A AU2014229638A AU2014229638B2 AU 2014229638 B2 AU2014229638 B2 AU 2014229638B2 AU 2014229638 A AU2014229638 A AU 2014229638A AU 2014229638 A AU2014229638 A AU 2014229638A AU 2014229638 B2 AU2014229638 B2 AU 2014229638B2
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- AU
- Australia
- Prior art keywords
- zro
- compound
- palmitoyl
- benzoyl
- eryi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC=C[C@]([C@](CO*)NC(C)=O)O Chemical compound CC=C[C@]([C@](CO*)NC(C)=O)O 0.000 description 8
- SZBAHLKUFYTSHY-FQKKNNILSA-N C/C=C/[C@H](CCOP(OCCBr)(Br)=O)O Chemical compound C/C=C/[C@H](CCOP(OCCBr)(Br)=O)O SZBAHLKUFYTSHY-FQKKNNILSA-N 0.000 description 1
- HCEKSPDSQNWZAO-WSKFYRRCSA-N CC(C)(C)OC(N1C(C)(C)OC[C@H]1C/C=C/C)=O Chemical compound CC(C)(C)OC(N1C(C)(C)OC[C@H]1C/C=C/C)=O HCEKSPDSQNWZAO-WSKFYRRCSA-N 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)N)O Chemical compound CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)N)O WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- SBMUNILHNJLMBF-UHFFFAOYSA-N O=P1(OCCO1)Cl Chemical compound O=P1(OCCO1)Cl SBMUNILHNJLMBF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/141—Esters of phosphorous acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/24—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2018267598A AU2018267598A1 (en) | 2013-03-15 | 2018-11-21 | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361801641P | 2013-03-15 | 2013-03-15 | |
| US61/801,641 | 2013-03-15 | ||
| EP13306056.6 | 2013-07-23 | ||
| EP13306056 | 2013-07-23 | ||
| PCT/IB2014/000494 WO2014140787A2 (en) | 2013-03-15 | 2014-03-14 | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018267598A Division AU2018267598A1 (en) | 2013-03-15 | 2018-11-21 | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014229638A1 AU2014229638A1 (en) | 2015-08-20 |
| AU2014229638B2 true AU2014229638B2 (en) | 2018-09-06 |
Family
ID=51538203
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014229638A Active AU2014229638B2 (en) | 2013-03-15 | 2014-03-14 | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| AU2018267598A Abandoned AU2018267598A1 (en) | 2013-03-15 | 2018-11-21 | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018267598A Abandoned AU2018267598A1 (en) | 2013-03-15 | 2018-11-21 | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
Country Status (16)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011008599A (es) | 2009-02-16 | 2011-11-18 | Cerenis Therapeutics Sa | Peptidos mimeticos de la apolipoproteina a-i. |
| HRP20171587T1 (hr) | 2010-10-18 | 2017-12-01 | Cerenis Therapeutics Holding Sa | Spojevi, pripravci i postupci pogodni za mobilizaciju kolesterola |
| US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| SG11201506456VA (en) * | 2013-03-15 | 2015-09-29 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| US20190046608A1 (en) | 2017-08-10 | 2019-02-14 | Cerenis Therapeutics Holding Sa | Apomers |
| TW201919712A (zh) | 2017-08-10 | 2019-06-01 | 法商塞勒尼斯醫療控股公司 | 運送子(cargomers) |
| CN111757886A (zh) * | 2018-03-27 | 2020-10-09 | 日油株式会社 | 鞘磷脂衍生的脂质及其生产方法 |
| JP7303618B2 (ja) * | 2018-10-05 | 2023-07-05 | 日本精化株式会社 | スフィンゴリン脂質前駆体及びその製造方法、並びに、スフィンゴリン脂質の製造方法 |
| WO2021209808A1 (en) | 2020-04-16 | 2021-10-21 | Abionyx Pharma Sa | Cer-001 therapy for treating kidney disease |
| KR20230004605A (ko) | 2020-04-16 | 2023-01-06 | 아비오닉스 파마 에스에이 | 지질 결합 단백질-기반 복합체를 사용하여 급성 상태를 치료하는 방법 |
| AU2021254856A1 (en) | 2020-04-16 | 2022-11-10 | Abionyx Pharma Sa | CER-001 therapy for treating kidney disease |
| CA3197168A1 (en) | 2020-10-01 | 2022-04-07 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| CA3216226A1 (en) | 2021-04-15 | 2022-10-20 | Abionyx Pharma Sa | Use of lipid binding protein-based complexes in organ preservation solutions |
| US20250230208A1 (en) | 2022-04-06 | 2025-07-17 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| CN119317440A (zh) | 2022-04-06 | 2025-01-14 | 阿比奥尼克斯制药公司 | 使用基于脂质结合蛋白的复合物治疗白细胞增多、内皮功能障碍和心脏炎的方法 |
| WO2023237935A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein-based complexes |
| CA3258787A1 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | METHODS OF TREATMENT OF HYPERINFLAMMATORY DISEASES USING LIPID-BINDING PROTEIN COMPLEXES |
| IL317896A (en) | 2022-06-28 | 2025-02-01 | Abionyx Pharma Sa | Compounds and processes for the synthesis of sphingomyelins |
| KR20260010675A (ko) | 2023-01-13 | 2026-01-21 | 아비오닉스 파마 에스에이 | 지질 결합 단백질 분자 치료 |
| IL327995A (en) | 2023-10-31 | 2026-06-01 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5220043A (en) * | 1991-03-21 | 1993-06-15 | Ohio University | Synthesis of D-erythro-sphingomyelins |
| WO2014108564A1 (fr) * | 2013-01-14 | 2014-07-17 | M2I Development | Nouveaux intermédiaires de synthèse permettant d'accéder avec de bons rendements à des dérivés de sphingosines, céramides et sphingomyelines |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0146810A3 (de) | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| US5766627A (en) | 1993-11-16 | 1998-06-16 | Depotech | Multivescular liposomes with controlled release of encapsulated biologically active substances |
| HUT75162A (en) | 1993-11-16 | 1997-04-28 | Depotech Corp | Vesicles with controlled release of actives |
| EP1053243B1 (en) | 1998-02-12 | 2011-03-30 | Emory University | Sphingolipid derivatives and their methods of use |
| JP2004002215A (ja) * | 2002-05-23 | 2004-01-08 | National Institute Of Advanced Industrial & Technology | スフィンゴ脂質誘導体の製造方法 |
| WO2005068480A1 (en) | 2004-01-15 | 2005-07-28 | Biolab Ltd. | Sphingomyelin, intermediates thereof and methods for preparation of same |
| AU2005251691A1 (en) | 2004-05-17 | 2005-12-22 | Tekmira Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
| ES2317259T3 (es) * | 2004-06-29 | 2009-04-16 | Jado Technologies Gmbh | Esfingolipidos contra procesos patologicos en baldas lipidicas. |
| JP2006045113A (ja) | 2004-08-04 | 2006-02-16 | Kemikurea:Kk | リン酸エステル類 |
| JP4825947B2 (ja) | 2004-08-04 | 2011-11-30 | 学校法人関西学院 | 不飽和アミノジオール類の製造方法 |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| AR057456A1 (es) | 2005-07-20 | 2007-12-05 | Merck & Co Inc | Inhibidores de la proteasa ns3 del vhc |
| JP2007204384A (ja) | 2006-01-31 | 2007-08-16 | Kemikurea:Kk | 光学活性リン酸誘導体およびこれを用いた光学活性スフィンゴシン１−リン酸誘導体の製造方法 |
| WO2008096880A1 (ja) * | 2007-02-09 | 2008-08-14 | Gifu University | スフィンゴ糖脂質の合成法 |
| WO2008111450A1 (ja) | 2007-03-09 | 2008-09-18 | Otsuka Chemical Co., Ltd. | スフィンゴシン化合物、その製造方法及びスフィンゴミエリナーゼ阻害剤 |
| WO2010041255A2 (en) | 2008-10-07 | 2010-04-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Liposomal systems comprising sphingomyelin |
| LT2673296T (lt) | 2011-02-07 | 2019-02-25 | Cerenis Therapeutics Holding Sa | Lipoproteino kompleksai ir jų gamyba ir jų panaudojimai |
| US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| SG11201506456VA (en) | 2013-03-15 | 2015-09-29 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
-
2014
- 2014-03-14 SG SG11201506456VA patent/SG11201506456VA/en unknown
- 2014-03-14 JP JP2015562366A patent/JP6438417B2/ja active Active
- 2014-03-14 AU AU2014229638A patent/AU2014229638B2/en active Active
- 2014-03-14 SG SG10201804887YA patent/SG10201804887YA/en unknown
- 2014-03-14 EP EP18160532.0A patent/EP3363805B1/en active Active
- 2014-03-14 KR KR1020157025911A patent/KR20150132188A/ko not_active Withdrawn
- 2014-03-14 EP EP20214357.4A patent/EP3842443B1/en active Active
- 2014-03-14 ES ES20214357T patent/ES3017659T3/es active Active
- 2014-03-14 CN CN201480015700.6A patent/CN105051051B/zh active Active
- 2014-03-14 MX MX2015012877A patent/MX387128B/es unknown
- 2014-03-14 EP EP14729036.5A patent/EP2970344A2/en not_active Withdrawn
- 2014-03-14 WO PCT/IB2014/000494 patent/WO2014140787A2/en not_active Ceased
- 2014-03-14 DK DK18160532.0T patent/DK3363805T3/da active
- 2014-03-14 BR BR112015023558A patent/BR112015023558A2/pt not_active Application Discontinuation
- 2014-03-14 CA CA2900902A patent/CA2900902C/en active Active
- 2014-03-14 HK HK16102047.1A patent/HK1214266A1/zh unknown
- 2014-03-14 US US14/213,269 patent/US20140316154A1/en not_active Abandoned
-
2015
- 2015-04-22 US US14/693,520 patent/US9643915B2/en active Active
- 2015-08-14 ZA ZA2015/05860A patent/ZA201505860B/en unknown
- 2015-08-19 PH PH12015501835A patent/PH12015501835A1/en unknown
-
2017
- 2017-04-04 US US15/478,532 patent/US20170204122A1/en not_active Abandoned
-
2018
- 2018-06-21 JP JP2018117808A patent/JP2018168171A/ja active Pending
- 2018-11-21 AU AU2018267598A patent/AU2018267598A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5220043A (en) * | 1991-03-21 | 1993-06-15 | Ohio University | Synthesis of D-erythro-sphingomyelins |
| WO2014108564A1 (fr) * | 2013-01-14 | 2014-07-17 | M2I Development | Nouveaux intermédiaires de synthèse permettant d'accéder avec de bons rendements à des dérivés de sphingosines, céramides et sphingomyelines |
Non-Patent Citations (2)
| Title |
|---|
| Murakami, M. et al ., "An Efficient Synthesis of Short-chain Sphingomyelin Analogs and Their Susceptibility to Hydrolysis Catalyzed by Sphingomyelinase", Bioorganic & Medicinal Chemistry Letters, 1997, Vol. 7, No. 13, pages 1725-1728. * |
| Weiss A., "New approaches to synthesis of stereospeci¿c sphingomyelin", Chemistry and Physics of Lipids, 1999, Vol. 102 pages 3-12. * |
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