AU2014224599B2 - Treatment and prevention of remote ischemia-reperfusion injury - Google Patents

Treatment and prevention of remote ischemia-reperfusion injury Download PDF

Info

Publication number
AU2014224599B2
AU2014224599B2 AU2014224599A AU2014224599A AU2014224599B2 AU 2014224599 B2 AU2014224599 B2 AU 2014224599B2 AU 2014224599 A AU2014224599 A AU 2014224599A AU 2014224599 A AU2014224599 A AU 2014224599A AU 2014224599 B2 AU2014224599 B2 AU 2014224599B2
Authority
AU
Australia
Prior art keywords
ser
leu
thr
val
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2014224599A
Other languages
English (en)
Other versions
AU2014224599A1 (en
Inventor
Claudia Duehrkop-Sisewitsch
Sylvia Miescher
Marc Nolte
Robert Rieben
Rolf SPIRIG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Bern
CSL Behring GmbH Deutschland
Original Assignee
Universitaet Bern
CSL Behring GmbH Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Bern, CSL Behring GmbH Deutschland filed Critical Universitaet Bern
Publication of AU2014224599A1 publication Critical patent/AU2014224599A1/en
Assigned to CSL BEHRING GMBH, UNIVERSITAET BERN reassignment CSL BEHRING GMBH Amend patent request/document other than specification (104) Assignors: CSL BEHRING GMBH, UNIVERSITAT BERN
Application granted granted Critical
Publication of AU2014224599B2 publication Critical patent/AU2014224599B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Microbiology (AREA)
AU2014224599A 2013-03-08 2014-03-07 Treatment and prevention of remote ischemia-reperfusion injury Active AU2014224599B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13158478 2013-03-08
EP13158478.1 2013-03-08
PCT/EP2014/054489 WO2014135694A1 (en) 2013-03-08 2014-03-07 Treatment and prevention of remote ischemia-reperfusion injury

Publications (2)

Publication Number Publication Date
AU2014224599A1 AU2014224599A1 (en) 2015-08-20
AU2014224599B2 true AU2014224599B2 (en) 2018-11-08

Family

ID=47833003

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014224599A Active AU2014224599B2 (en) 2013-03-08 2014-03-07 Treatment and prevention of remote ischemia-reperfusion injury

Country Status (10)

Country Link
US (2) US10286047B2 (OSRAM)
EP (1) EP2964255B1 (OSRAM)
JP (2) JP6636334B2 (OSRAM)
KR (1) KR102403299B1 (OSRAM)
CN (1) CN105188750A (OSRAM)
AU (1) AU2014224599B2 (OSRAM)
CA (1) CA2901225C (OSRAM)
DK (1) DK2964255T3 (OSRAM)
ES (1) ES2844189T3 (OSRAM)
WO (1) WO2014135694A1 (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2683397T3 (pl) 2011-03-09 2018-01-31 Csl Behring Gmbh Inhibitory czynnika XII do podawania w zabiegach medycznych obejmujących kontakt z powierzchniami sztucznymi
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
US10286047B2 (en) 2013-03-08 2019-05-14 Csl Behring Gmbh Treatment and prevention of remote ischemia-reperfusion injury
PL3071219T3 (pl) * 2013-11-22 2019-04-30 Shire Viropharma Inc Sposoby leczenia zależnego od przeciwciała odrzucenia przeszczepu narządu u pacjentów za pomocą inhibitora esterazy c1
DK3157548T3 (da) 2014-06-18 2021-09-06 Csl Behring Gmbh Terapi anvendelse af en faktor xii-inhibitor i en neurotraumatisk sygdom
US20160130324A1 (en) * 2014-10-31 2016-05-12 Shire Human Genetic Therapies, Inc. C1 Inhibitor Fusion Proteins and Uses Thereof
MA43270A (fr) * 2015-11-19 2021-06-02 Takeda Pharmaceuticals Co Inhibiteur de la c1 estérase humaine recombinante et ses utilisations
AU2017247004B2 (en) 2016-04-06 2022-07-07 Csl Limited Method of treating atherosclerosis
CN109562149A (zh) 2016-08-05 2019-04-02 德国杰特贝林生物制品有限公司 C1酯酶抑制剂的药物制剂
US11903963B2 (en) 2017-03-10 2024-02-20 The University Of North Carolina At Chapel Hill Short-acting heparin-based anticoagulant compounds and methods
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
EP3691653B1 (en) 2017-11-03 2025-03-12 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
US11505619B2 (en) 2017-12-15 2022-11-22 Csl Limited Use of a FXIIa-inhibitor in the treatment of renal fibrosis and/or chronic kidney disease
WO2019246264A1 (en) 2018-06-20 2019-12-26 The University Of North Carolina At Chapel Hill Cell protective methods and compositions
CN108852308B (zh) * 2018-06-22 2021-03-30 苏州高新区人民医院 一种基于多参数影像技术优化检测体系的超时间窗ais临床再灌注方法
WO2020210491A1 (en) * 2019-04-10 2020-10-15 Pantheryx, Inc. Methods and compositions for reducing gut ischemia/reperfusion-induced injury
JP7788281B2 (ja) * 2019-06-12 2025-12-18 シーエスエル・イノベーション・プロプライエタリー・リミテッド 可溶性補体受容体１型変異体コンジュゲートおよびその使用
EP4041251A4 (en) * 2019-11-13 2023-11-29 The University of North Carolina at Chapel Hill Heparan sulfate (hs) oligosaccharides effect in liver ischemia reperfusion injury

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090777A (en) * 1993-09-01 2000-07-18 Stiching Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Method to reduce myocardial injury during acute myocardial infarction
WO2007073186A2 (en) * 2005-12-21 2007-06-28 Pharming Intellectual Property Bv Use of c1 inhibitor for the prevention of ischemia-reperfusion injury
US20090233852A1 (en) * 2004-09-27 2009-09-17 Dyax Corp. Kallikrein Inhibitors and Anti-Thrombolytic Agents and Uses Thereof

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5714358A (en) 1980-07-02 1982-01-25 Toray Industries Antithrombus medical material
US4383219A (en) 1980-08-19 1983-05-10 Indiana University Foundation Nuclear magnetic resonance spatial mapping
DE3228502A1 (de) 1982-07-30 1984-02-02 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung des c1-inaktivators und seine verwendung
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
US4963657A (en) 1988-06-09 1990-10-16 Temple University Of The Commonwealth System Of Higher Education Monoclonal antibodies to the light chain region of human factor XII and methods of preparing and using the same
CA2006596C (en) 1988-12-22 2000-09-05 Rika Ishikawa Chemically-modified g-csf
GB8901859D0 (en) 1989-01-27 1989-03-15 Shield Diagnostics Limited Diagnostic test
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
EP0534988A1 (en) 1990-05-10 1993-04-07 Cetus Corporation Inhibitors of factor xii activation and applications thereof
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
ATE240740T1 (de) 1991-03-15 2003-06-15 Amgen Inc Pegylation von polypeptiden
DE4222534A1 (de) 1992-07-09 1994-01-13 Behringwerke Ag Verwendung von Komplement-Inhibitoren zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie von entzündlichen Darm- und Hauterkrankungen sowie Purpura
DE4244735A1 (de) 1992-08-24 1994-03-31 Behringwerke Ag Verwendung von C1-Inaktivator zur Bekämpfung von Komplikationen bei der Anwendung von Zytokinen, endogenen Mediatoren, gentechnisch produzierten Mediator-Hybriden oder Wachstumsfaktoren im Rahmen der therapeutischen Anwendung dieser Substanzen
US5380299A (en) 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
JPH11501506A (ja) 1994-12-12 1999-02-09 ベス イスラエル デアコネス メディカル センター キメラ型サイトカインおよびその利用
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
US5786692A (en) 1995-08-18 1998-07-28 Brigham And Women's Hospital, Inc. Line scan diffusion imaging
DE19903693A1 (de) 1998-04-24 1999-10-28 Centeon Pharma Gmbh Protease zur Aktivierung des Gerinnungsfaktors VII
US5674236A (en) 1996-04-30 1997-10-07 Medtronic, Inc. Lancet for capillary puncture blood samples
JPH11209399A (ja) 1997-11-20 1999-08-03 Asahi Chem Ind Co Ltd 高比重リポ蛋白質を有効成分とする医薬組成物
US8088386B2 (en) 1998-03-20 2012-01-03 Genentech, Inc. Treatment of complement-associated disorders
GB9800817D0 (en) 1998-01-16 1998-03-11 Bio Discovery Ltd Serine protease inhibitors
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7053176B1 (en) 1999-09-16 2006-05-30 Altana Pharma Ag Combination of C1-INH and lung surfactant for the treatment of respiratory disorders
JP2001276217A (ja) 2000-04-04 2001-10-09 Dountsuendorufaa Udo 単一又は複数の疾患のある患者での組織、血漿又は血液透析用のバイオコートされた吸着剤
AU2001266557A1 (en) 2000-04-12 2001-10-23 Human Genome Sciences, Inc. Albumin fusion proteins
DK1355919T3 (da) 2000-12-12 2011-03-14 Medimmune Llc Molekyler med længere halveringstider, sammensætninger og anvendelser deraf
WO2003034944A1 (de) 2001-10-15 2003-05-01 Hemoteq Gmbh Beschichtung von stents zur verhinderung von restenose
EP1471853B1 (en) 2002-02-06 2017-03-22 OrbusNeich Medical, Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
CN1326496C (zh) 2002-02-11 2007-07-18 黄金－T技术股份有限公司 预防血栓形成的装置
IL163586A0 (en) 2002-02-21 2005-12-18 Quark Biotech Inc Methods of preventing or treating brain ischemia or brain injury
EP1572936A2 (en) 2002-03-05 2005-09-14 Eli Lilly And Company Heterologous g-csf fusion proteins
EP1573339A2 (en) 2002-12-20 2005-09-14 Axis-Shield Diagnostics Limited Detection or determination of variants of factor xiia
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
CA2515453C (en) 2003-02-21 2013-09-24 Tanox, Inc. Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury
US20050176108A1 (en) 2003-03-13 2005-08-11 Young-Min Kim Physiologically active polypeptide conjugate having prolonged in vivo half-life
ATE497783T1 (de) 2003-05-06 2011-02-15 Syntonix Pharmaceuticals Inc Gerinnungsfaktor vii-fc chimäre proteine zur behandlung von hämostatischen krankheiten
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
ES2830499T3 (es) 2003-05-16 2021-06-03 Pharming Intellectual Property B V Inhibidor de C1 con una semivida corta para un tratamiento transitorio
AU2004251145C1 (en) 2003-06-12 2011-04-14 Eli Lilly And Company GLP-1 analog fusion proteins
US20050059660A1 (en) 2003-08-01 2005-03-17 Pharmacia & Upjohn Company Novel combination
EP1670931A2 (en) 2003-09-05 2006-06-21 GTC Biotherapeutics, Inc. Method for the production of fusion proteins in transgenic mammal milk
RU2370276C2 (ru) 2003-12-31 2009-10-20 Мерк Патент Гмбх Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ
US7670595B2 (en) 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
JP4958555B2 (ja) 2004-09-22 2012-06-20 協和発酵キリン株式会社 安定化されたヒトＩｇＧ４抗体
US20070135620A1 (en) 2004-11-12 2007-06-14 Xencor, Inc. Fc variants with altered binding to FcRn
AU2005318464B2 (en) 2004-12-23 2012-02-23 Csl Behring Gmbh Prevention of thrombus formation and/or stabilization
WO2010080538A1 (en) 2008-12-19 2010-07-15 Macrogenics, Inc. Covalent diabodies and uses thereof
US20070196367A1 (en) 2006-02-22 2007-08-23 Valentin Dinu Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
AU2007234006A1 (en) 2006-03-31 2007-10-11 Adenobio N.V. Compositions, methods, and kits using adenosine and inosine in combination for diagnosis and treatment
GB0607515D0 (en) 2006-04-13 2006-05-24 Axis Shield Diagnostics Ltd Anti-factor xlla therapy
PT2698166E (pt) 2006-10-10 2016-01-27 Regenesance B V Inibição do complemento para regeneração nervosa aprimorada
PE20081834A1 (es) 2006-12-31 2009-01-16 Boehringer Ingelheim Int Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos
US20100119512A1 (en) 2007-01-25 2010-05-13 Joslin Diabetes Center Methods of diagnosing, treating, and preventing increased vascular permeability
CA2678001C (en) 2007-02-12 2017-07-11 Stefan Schulte Therapeutic application of kazal-type serine protease inhibitors
LT3002298T (lt) 2007-11-21 2019-12-10 Univ Oregon Health & Science Monokloniniai antikūnai prieš faktorių xi ir jų panaudojimo būdai
WO2010049423A1 (en) 2008-10-27 2010-05-06 Life Sciences Research Partners Vzw Effects of nitric oxide inhalation on long-term myocardial reperfusion injury
US20100143325A1 (en) 2008-12-09 2010-06-10 Vascular Laboratory, Inc. Composition And Methods Involving Thrombolytic Agents
JP2012515556A (ja) 2009-01-23 2012-07-12 バイオジェン・アイデック・エムエイ・インコーポレイテッド 低下したエフェクタ機能を有する安定化Ｆｃポリペプチドおよび使用方法
MY157239A (en) 2009-05-27 2016-05-13 Baxalta Inc A method to produce a highly concentrated immunoglobulin preparation for subcutaneous use
EP2497489A1 (en) 2011-03-09 2012-09-12 CSL Behring GmbH Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
PL2683397T3 (pl) 2011-03-09 2018-01-31 Csl Behring Gmbh Inhibitory czynnika XII do podawania w zabiegach medycznych obejmujących kontakt z powierzchniami sztucznymi
IL230564B2 (en) 2011-07-22 2023-09-01 Csl Ltd Anticoagulant monoclonal antibodies anti–factor xii/fxiia, a method for their preparation, a pharmaceutical compound containing them and medical uses.
EP2758076B1 (en) 2011-09-24 2018-12-12 CSL Behring GmbH Combination therapy using immunoglobulin and c1-inhibitor
EP2623110A1 (en) 2012-01-31 2013-08-07 CSL Behring GmbH Factor XII inhibitors for the treatment of neurological inflammatory disorders
KR102419640B1 (ko) * 2013-01-20 2022-07-12 다케다 파머수티컬 컴패니 리미티드 pKal 매개 장애의 평가, 검정 및 치료
US10286047B2 (en) 2013-03-08 2019-05-14 Csl Behring Gmbh Treatment and prevention of remote ischemia-reperfusion injury
KR20160026905A (ko) 2013-06-28 2016-03-09 체에스엘 베링 게엠베하 인자 ｘｉｉ 억제제 및 ｃ1-억제제를 이용한 병용 치료요법
AU2017247004B2 (en) 2016-04-06 2022-07-07 Csl Limited Method of treating atherosclerosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090777A (en) * 1993-09-01 2000-07-18 Stiching Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Method to reduce myocardial injury during acute myocardial infarction
US20090233852A1 (en) * 2004-09-27 2009-09-17 Dyax Corp. Kallikrein Inhibitors and Anti-Thrombolytic Agents and Uses Thereof
WO2007073186A2 (en) * 2005-12-21 2007-06-28 Pharming Intellectual Property Bv Use of c1 inhibitor for the prevention of ischemia-reperfusion injury

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FRANTZ STEFAN ET AL, CIRCULATION, & 80TH ANNUAL SCIENTIFIC SESSION OF THE AMERICAN-HEART-ASSOCIATION; NOV 04 -07, 2007, (2007-10), vol. 116, no. 16, Suppl. S, page 134 *
GEORG HORSTICK, "C1-Esterase Inhibitor in Ischemia and Reperfusion", Immunobiol. (2002), Vol. 205, pp. 552-562. *
Grunenfelder et al., Journal of Investigative Surgery, 2002; Vol. 15, Pages 281-286. *
LU F ET AL, "The effect of C1 inhibitor on intestinal ischaemia and reperfusion injury", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 45, no. 16, doi:1 0.101 6/J.MOLIMM.2008.08.181, ISSN 0161-5890, (2008-10-01), page 4156, (2008-10-01) *

Also Published As

Publication number Publication date
CA2901225C (en) 2023-09-19
JP2016511267A (ja) 2016-04-14
US20160008442A1 (en) 2016-01-14
HK1216607A1 (zh) 2016-11-25
KR20150128888A (ko) 2015-11-18
JP2020007362A (ja) 2020-01-16
DK2964255T3 (da) 2021-02-08
US20190269766A1 (en) 2019-09-05
CA2901225A1 (en) 2014-09-12
WO2014135694A1 (en) 2014-09-12
ES2844189T3 (es) 2021-07-21
AU2014224599A1 (en) 2015-08-20
US10286047B2 (en) 2019-05-14
JP6636334B2 (ja) 2020-01-29
CN105188750A (zh) 2015-12-23
US10973891B2 (en) 2021-04-13
EP2964255A1 (en) 2016-01-13
JP7666891B2 (ja) 2025-04-22
EP2964255B1 (en) 2020-11-04
KR102403299B1 (ko) 2022-06-03

Similar Documents

Publication Publication Date Title
US10973891B2 (en) Treatment and prevention of remote ischemia-reperfusion injury
KR102067394B1 (ko) 신경학적 염증성 장애의 치료를 위한 인자 ｘｉｉ 억제제
US20240398914A1 (en) Combination therapy using a factor xii inhibitor and a c-1 inhibitor
JP6744313B2 (ja) 血漿カリクレインおよび第ｘｉｉ因子に対する二重特異性抗体
US20140323404A1 (en) Anticoagulant polypeptide and applications thereof
EP3157548B1 (en) Therapy using a factor xii inhibitor in a neurotraumatic disorder
CN113474373B (zh) 具有抗血栓形成和抗炎作用的新型抗因子xi人源化抗体及其用途
KR20230030644A (ko) 항-단백질 단일-도메인 항체 및 이를 포함하는 폴리펩타이드
HK1216607B (en) Treatment and prevention of remote ischemia-reperfusion injury
CN119233992A (zh) 抗活化蛋白c的人抗体及其用途
HK1220132B (en) Combination therapy using a factor xii inhibitor and a c1-inhibitor
HK1232804B (en) Therapy using a factor xii inhibitor in a neurotraumatic disorder

Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ SPIRIG, ROLF; MIESCHER, SYLVIA; NOLTE, MARC; DUEHRKOP-SISEWITSCH, CLAUDIA AND RIEBEN, ROBERT

FGA Letters patent sealed or granted (standard patent)