AU2014212490A1 - Spiro-lactam NMDA receptor modulators and uses thereof - Google Patents

Spiro-lactam NMDA receptor modulators and uses thereof Download PDF

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Publication number
AU2014212490A1
AU2014212490A1 AU2014212490A AU2014212490A AU2014212490A1 AU 2014212490 A1 AU2014212490 A1 AU 2014212490A1 AU 2014212490 A AU2014212490 A AU 2014212490A AU 2014212490 A AU2014212490 A AU 2014212490A AU 2014212490 A1 AU2014212490 A1 AU 2014212490A1
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AU
Australia
Prior art keywords
compound
alkyl
group
halogen
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2014212490A
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English (en)
Inventor
M. Amin Khan
John A. Lowe Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptinyx Inc
Original Assignee
Aptinyx Inc
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Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50097881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2014212490(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aptinyx Inc filed Critical Aptinyx Inc
Publication of AU2014212490A1 publication Critical patent/AU2014212490A1/en
Assigned to Aptinyx, Inc. reassignment Aptinyx, Inc. Request for Assignment Assignors: NAUREX, INC.
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
AU2014212490A 2013-01-29 2014-01-29 Spiro-lactam NMDA receptor modulators and uses thereof Abandoned AU2014212490A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361757939P 2013-01-29 2013-01-29
US61/757,939 2013-01-29
PCT/US2014/013626 WO2014120789A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
AU2014212490A1 true AU2014212490A1 (en) 2015-07-30

Family

ID=50097881

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014212490A Abandoned AU2014212490A1 (en) 2013-01-29 2014-01-29 Spiro-lactam NMDA receptor modulators and uses thereof

Country Status (16)

Country Link
US (2) US9738650B2 (ko)
EP (1) EP2951186B1 (ko)
JP (1) JP2016506961A (ko)
KR (1) KR20150110586A (ko)
CN (1) CN105026401A (ko)
AU (1) AU2014212490A1 (ko)
BR (1) BR112015018095A2 (ko)
CA (1) CA2899010A1 (ko)
CL (1) CL2015002124A1 (ko)
EA (1) EA201591404A1 (ko)
IL (1) IL240165A0 (ko)
MX (1) MX2015009778A (ko)
PE (1) PE20151438A1 (ko)
PH (1) PH12015501600A1 (ko)
SG (1) SG11201505937SA (ko)
WO (1) WO2014120789A1 (ko)

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WO2010033757A1 (en) 2008-09-18 2010-03-25 Naurex, Inc. Nmda receptor modulators and uses thereof
KR20150110787A (ko) 2013-01-29 2015-10-02 노렉스, 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
KR20150110586A (ko) 2013-01-29 2015-10-02 노렉스, 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
BR112015018089B1 (pt) 2013-01-29 2022-09-20 Aptinyx Inc Compostos moduladores de receptor de nmda de espiro-lactama, composição farmacêutica os compreendendo e uso dos mesmos
PE20151416A1 (es) 2013-01-29 2015-10-10 Naurex Inc Moduladores de receptores nmda de espiro-lactama y sus usos
EP2951185B1 (en) 2013-01-29 2016-12-21 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
KR102128675B1 (ko) 2016-05-19 2020-06-30 앱티닉스 인크. 스피로-락탐 nmda 수용체 조정제 및 그의 용도
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
CN109937204B (zh) 2016-08-01 2022-11-25 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
AU2017305240B2 (en) * 2016-08-01 2021-12-09 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
EP3490990B1 (en) 2016-08-01 2023-12-06 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam nmda modulators and methods of using same
WO2018026763A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
IL264496B (en) * 2016-08-01 2022-09-01 Aptinyx Inc Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
US11578072B2 (en) * 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
MX2020008106A (es) * 2018-01-31 2020-09-25 Aptinyx Inc Moduladores del receptor nmda espiro-lactama y usos de los mismos.
WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
CN109485598A (zh) * 2018-11-29 2019-03-19 河南师范大学 一种去除氨基上喹啉保护基的新方法
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EP4007574A4 (en) * 2019-08-01 2023-08-02 Aptinyx Inc. METHODS OF TREATING DISORDERS ASSOCIATED WITH HIGH LEVELS OF ANTIBODIES INTERACTING WITH THE NMDA RECEPTOR
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

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BR112015018089B1 (pt) 2013-01-29 2022-09-20 Aptinyx Inc Compostos moduladores de receptor de nmda de espiro-lactama, composição farmacêutica os compreendendo e uso dos mesmos
PE20151416A1 (es) 2013-01-29 2015-10-10 Naurex Inc Moduladores de receptores nmda de espiro-lactama y sus usos

Also Published As

Publication number Publication date
CL2015002124A1 (es) 2015-12-04
KR20150110586A (ko) 2015-10-02
EA201591404A1 (ru) 2016-01-29
CA2899010A1 (en) 2014-08-07
PH12015501600A1 (en) 2015-10-19
EP2951186B1 (en) 2018-07-25
IL240165A0 (en) 2015-09-24
US10253032B2 (en) 2019-04-09
JP2016506961A (ja) 2016-03-07
US9738650B2 (en) 2017-08-22
SG11201505937SA (en) 2015-09-29
EP2951186A1 (en) 2015-12-09
WO2014120789A1 (en) 2014-08-07
US20150376195A1 (en) 2015-12-31
US20180155354A1 (en) 2018-06-07
PE20151438A1 (es) 2015-10-10
CN105026401A (zh) 2015-11-04
MX2015009778A (es) 2016-02-09
BR112015018095A2 (pt) 2017-07-18

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PC1 Assignment before grant (sect. 113)

Owner name: APTINYX, INC.

Free format text: FORMER APPLICANT(S): NAUREX, INC.

MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application