AU2013267209B2 - Modulation of hepatitis B virus cccDNA transcription - Google Patents

Modulation of hepatitis B virus cccDNA transcription Download PDF

Info

Publication number
AU2013267209B2
AU2013267209B2 AU2013267209A AU2013267209A AU2013267209B2 AU 2013267209 B2 AU2013267209 B2 AU 2013267209B2 AU 2013267209 A AU2013267209 A AU 2013267209A AU 2013267209 A AU2013267209 A AU 2013267209A AU 2013267209 B2 AU2013267209 B2 AU 2013267209B2
Authority
AU
Australia
Prior art keywords
group
hydrogen
inhibitor
alkyl
hbv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013267209A
Other languages
English (en)
Other versions
AU2013267209A1 (en
Inventor
Harold R. Almond
Timothy M. Block
Jinhong Chang
Ju-Tao Guo
William A. Kinney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BARUCH S BLUMBERG INSTITUTE
Drexel University
Original Assignee
BARUCH S BLUMBERG INST
Drexel University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BARUCH S BLUMBERG INST, Drexel University filed Critical BARUCH S BLUMBERG INST
Publication of AU2013267209A1 publication Critical patent/AU2013267209A1/en
Application granted granted Critical
Publication of AU2013267209B2 publication Critical patent/AU2013267209B2/en
Priority to AU2017202675A priority Critical patent/AU2017202675A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123Tripeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126Tetrapeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013267209A 2012-06-01 2013-05-31 Modulation of hepatitis B virus cccDNA transcription Ceased AU2013267209B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017202675A AU2017202675A1 (en) 2012-06-01 2017-04-21 Modulation of hepatitis b virus cccdna transcription

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261654374P 2012-06-01 2012-06-01
US61/654,374 2012-06-01
PCT/US2013/043691 WO2013181584A2 (en) 2012-06-01 2013-05-31 Modulation of hepatitis b virus cccdna transcription

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017202675A Division AU2017202675A1 (en) 2012-06-01 2017-04-21 Modulation of hepatitis b virus cccdna transcription

Publications (2)

Publication Number Publication Date
AU2013267209A1 AU2013267209A1 (en) 2014-12-18
AU2013267209B2 true AU2013267209B2 (en) 2017-02-02

Family

ID=49674087

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013267209A Ceased AU2013267209B2 (en) 2012-06-01 2013-05-31 Modulation of hepatitis B virus cccDNA transcription
AU2017202675A Abandoned AU2017202675A1 (en) 2012-06-01 2017-04-21 Modulation of hepatitis b virus cccdna transcription

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017202675A Abandoned AU2017202675A1 (en) 2012-06-01 2017-04-21 Modulation of hepatitis b virus cccdna transcription

Country Status (13)

Country Link
US (3) US9623071B2 (enExample)
EP (1) EP2854832A4 (enExample)
JP (1) JP6431478B2 (enExample)
KR (1) KR101945578B1 (enExample)
CN (1) CN104507488A (enExample)
AU (2) AU2013267209B2 (enExample)
BR (1) BR112014029697A2 (enExample)
CA (1) CA2874828A1 (enExample)
HK (1) HK1208823A1 (enExample)
IL (1) IL235912A0 (enExample)
PH (1) PH12014502659A1 (enExample)
SG (1) SG11201407970VA (enExample)
WO (1) WO2013181584A2 (enExample)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5977837B2 (ja) 2011-12-21 2016-08-24 ノヴィラ・セラピューティクス・インコーポレイテッド B型肝炎抗ウイルス剤
MX373711B (es) 2012-08-28 2020-05-08 Janssen Sciences Ireland Uc Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b.
WO2014074906A1 (en) * 2012-11-09 2014-05-15 Indiana University Research And Technology Corporation Alternative uses for hbv assembly effectors
JP2016501531A (ja) 2012-12-12 2016-01-21 ザ・ブロード・インスティテュート・インコーポレイテッド 配列操作および治療適用のための系、方法および組成物の送達、エンジニアリングおよび最適化
ES2701749T3 (es) 2012-12-12 2019-02-25 Broad Inst Inc Métodos, modelos, sistemas y aparatos para identificar secuencias diana para enzimas Cas o sistemas CRISPR-Cas para secuencias diana y transmitir resultados de los mismos
WO2014093701A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
DK2961732T3 (en) 2013-02-28 2017-07-10 Janssen Sciences Ireland Uc SULFAMOYLARYLAMIDS AND USE THEREOF AS MEDICINES TO TREAT HEPATITIS B
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
CN105102451B (zh) 2013-04-03 2018-09-18 爱尔兰詹森科学公司 N-苯基-氨甲酰衍生物及其作为药物用于治疗乙型肝炎的用途
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
SG10201710487VA (en) 2013-06-17 2018-01-30 Broad Inst Inc Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for Targeting Disorders and Diseases Using Viral Components
EP3725885A1 (en) 2013-06-17 2020-10-21 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
EP3825406A1 (en) 2013-06-17 2021-05-26 The Broad Institute Inc. Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
WO2014204724A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
EP3011030B1 (en) 2013-06-17 2023-11-08 The Broad Institute, Inc. Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
KR102244937B1 (ko) 2013-07-25 2021-04-27 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 글리옥사미드 치환된 피롤아미드 유도체 및 b형 간염 치료용 의약으로서의 이의 용도
DK3060547T3 (en) 2013-10-23 2018-01-15 Janssen Sciences Ireland Uc CARBOXAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATMENT OF HEPATITS B
WO2015089364A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Crystal structure of a crispr-cas system, and uses thereof
EP3080271B1 (en) 2013-12-12 2020-02-12 The Broad Institute, Inc. Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
BR112016013547A2 (pt) 2013-12-12 2017-10-03 Broad Inst Inc Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
KR20160089530A (ko) 2013-12-12 2016-07-27 더 브로드 인스티튜트, 인코퍼레이티드 Hbv 및 바이러스 질병 및 질환을 위한 crispr­cas 시스템 및 조성물의 전달,용도 및 치료적 적용
WO2015089462A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
EP4219699A1 (en) 2013-12-12 2023-08-02 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9181288B2 (en) 2014-01-16 2015-11-10 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
EP3102225B1 (en) 2014-02-05 2020-03-25 Novira Therapeutics Inc. Combination therapy for treatment of hbv infections
US11078193B2 (en) 2014-02-06 2021-08-03 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
US9400280B2 (en) 2014-03-27 2016-07-26 Novira Therapeutics, Inc. Piperidine derivatives and methods of treating hepatitis B infections
MX375407B (es) 2014-06-20 2025-03-06 Univ Drexel Antígeno e de hepadnavirus marcado y su uso en el tamizado de sustancias antivirales.
EP3985115A1 (en) 2014-12-12 2022-04-20 The Broad Institute, Inc. Protected guide rnas (pgrnas)
AU2015369725A1 (en) 2014-12-24 2017-06-29 Massachusetts Institute Of Technology CRISPR having or associated with destabilization domains
US9884831B2 (en) 2015-03-19 2018-02-06 Novira Therapeutics, Inc. Azocane and azonane derivatives and methods of treating hepatitis B infections
WO2016161268A1 (en) 2015-04-01 2016-10-06 Enanta Pharmaceuticals, Inc. Hepatitis b antviral agents
US10738035B2 (en) 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2016205759A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
RU2752834C2 (ru) 2015-06-18 2021-08-09 Те Брод Инститьют, Инк. Мутации фермента crispr, уменьшающие нецелевые эффекты
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017015451A1 (en) * 2015-07-22 2017-01-26 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
KR101771309B1 (ko) * 2015-07-24 2017-08-24 재단법인 목암생명과학연구소 B형 간염 바이러스의 cccDNA 형성 억제용 약학 조성물
TW201718496A (zh) 2015-09-29 2017-06-01 諾維拉治療公司 B型肝炎抗病毒劑之晶型
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
CN109069488B (zh) 2016-03-07 2021-09-07 英安塔制药有限公司 乙型肝炎抗病毒剂
CN109640980A (zh) 2016-04-15 2019-04-16 诺维拉治疗公司 包含壳体装配抑制剂的组合和方法
KR20190027814A (ko) 2016-06-10 2019-03-15 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
EP3484489B1 (en) 2016-07-15 2025-06-18 Viracta Subsidiary, Inc. Hdac inhibitors for use with nk cell based therapies
RU2019120163A (ru) 2016-12-13 2021-01-15 Ам Сиенсес Инк Фармацевтическая композиция для предупреждения или лечения гепатита B
TWI811236B (zh) 2017-08-28 2023-08-11 美商因那塔製藥公司 B型肝炎抗病毒試劑
WO2019110589A1 (en) * 2017-12-04 2019-06-13 F. Hoffmann-La Roche Ag Pyrrolo[2,3-b]pyrazine compounds as cccdna inhibitors for the treatment of hepatitis b virus (hbv) infection
WO2019113175A1 (en) 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
TW201927789A (zh) 2017-12-06 2019-07-16 美商因那塔製藥公司 B型肝炎抗病毒試劑
WO2019143902A2 (en) 2018-01-22 2019-07-25 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
JP2021515769A (ja) 2018-03-14 2021-06-24 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー カプシド集合調節剤の投薬レジメン
WO2019191166A1 (en) 2018-03-29 2019-10-03 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
KR102273071B1 (ko) * 2018-06-12 2021-07-05 주식회사 에이엠사이언스 B형 간염 예방 또는 치료용 조성물
WO2019240504A1 (en) * 2018-06-12 2019-12-19 Am Sciences Co., Ltd. Modified oligonucleotides for inhibition of target gene expression
US10865211B2 (en) 2018-09-21 2020-12-15 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
CN112888480A (zh) * 2018-10-24 2021-06-01 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒疾病的新型三环化合物
US11198693B2 (en) 2018-11-21 2021-12-14 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
MA55020A (fr) 2019-02-22 2021-12-29 Janssen Sciences Ireland Unlimited Co Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b
AR119732A1 (es) 2019-05-06 2022-01-05 Janssen Sciences Ireland Unlimited Co Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb
KR20220034736A (ko) 2019-05-31 2022-03-18 비락타 서브시디어리 인크. 히스톤 데아세틸라제 억제제를 사용하여 바이러스 관련 암을 치료하는 방법
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
EP4037706A4 (en) * 2019-10-02 2023-09-13 University of Washington Compositions and methods for treatment of hepatitis b virus infection
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
EP4200419A2 (en) * 2020-08-21 2023-06-28 F. Hoffmann-La Roche AG Use of a1cf inhibitors for treating hepatitis b virus infection
CN112274516B (zh) * 2020-10-26 2022-08-05 中山大学附属第三医院 一种新型含碘抗病毒药物
IT202100005054A1 (it) * 2021-03-04 2022-09-04 Azienda Ospedaliero Univ Di Parma Composto farmaceutico per l’uso in un trattamento terapeutico dell’infezione cronica da hbv e metodo per l’identificazione di linfociti esauriti

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110245154A1 (en) * 2010-03-11 2011-10-06 Hemaquest Pharmaceuticals, Inc. Methods and Compositions for Treating Viral or Virally-Induced Conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051846A1 (en) 2000-12-22 2002-07-04 Zee, Ok Pyo Apicidin-derivatives, their synthetic methods, and antitumor compositions containing the same
US20100009970A1 (en) * 2008-03-19 2010-01-14 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US20110086869A1 (en) 2009-09-24 2011-04-14 The Trustees Of Boston University Methods for treating viral disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110245154A1 (en) * 2010-03-11 2011-10-06 Hemaquest Pharmaceuticals, Inc. Methods and Compositions for Treating Viral or Virally-Induced Conditions

Non-Patent Citations (28)

* Cited by examiner, † Cited by third party
Title
CAS Registry Number 1126426-52-5; STN Entry Date 25 March 2009; Cyclo[L-alanyl-(2S)-2-amino-8-oxodecanoyl-L-tryptophyl-L-leucyl] *
CAS Registry Number 1126426-54-7; STN Entry Date 25 March 2009; Cyclo[L-alanyl-(2S)-2-amino-8-oxodecanoyl-D-tryptophyl-L-leucyl] *
CAS Registry Number 1126426-56-9; STN Entry Date 25 March 2009; Cyclo[L-alanyl-(2S)-2-amino-8-(hydroxyamino)-8-oxooctanoyl-L-tryptophyl-L-leucyl] *
CAS Registry Number 1126426-59-2; STN Entry Date 25 March 2009; Cyclo[D-alanyl-(2S)-2-amino-8-oxodecanoyl-L-tryptophyl-L-leucyl] *
CAS Registry Number 1126426-60-5; STN Entry Date 25 March 2009; Cyclo[L-alanyl-(2R)-2-amino-8-oxodecanoyl-L-tryptophyl-L-leucyl] *
CAS Registry Number 1126426-63-8; STN Entry Date 25 March 2009; Cyclo[N-methyl-L-alanyl-(2S)-2-amino-8-oxodecanoyl-L-tryptophyl-L-leucyl] *
CAS Registry Number 1187754-56-8; STN Entry Date 09 October 2009; Cyclo-[L-alanyl-(2S)-2-amino-8-oxodecanoyl-L-tryptophyl-(3S)-3-amino-5-methylhexanoyl] *
CAS Registry Number 1187754-57-9; STN Entry Date 09 October 2009; Cyclo[L-alanyl-(2S)-2-amino-8-(hydroxyamino)-8-oxooctanoyl-L-trytophyl-(3S)-3-amino-5-methylhexanoyl] *
CAS Registry Number 1187754-68-2; STN Entry Date 09 October 2009; Cyclo[(3S)-3-amino-5-methylhexanoyl-N6-acetyl-L-lysyl-(2S)-2-amino-8-oxodecanoyl-L-tryptophyl] *
CAS Registry Number 1187754-69-3; STN Entry Date 09 October 2009; 1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone, 3-(1H-indol-3-ylmethyl)-13-(2-methylproperyl)-6,9-bis(6-oxooctyl)-(3S,6S,9S,13S)- *
CAS Registry Number 1187754-77-3; STN Entry Date 09 October 2009, Cyclo[(3S)-3-amino-5-methylhexanoyl-L-phenylalanyl-(2S)-2-amino-8-oxodecanoyl-L-tryptophyl] *
CAS Registry Number 1187754-79-5; STN Entry Date 09 October 2009, Cyclo[(2S)-2-amino-8-(hydroxyamino)-8-oxooctanoyl-L-tryptophyl-(3S)-3-amino-5-methylhexanoyl-L-phenylalanyl] *
CAS Registry Number 1316753-00-0; STN Entry Date 12 August 2011; 1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone,3-(1H-indol-3-ylmethyl)-9,10-dimethyl-13-(2-methylpropyl)-6-(6-oxooctyl)-(3S,6S,9S,13S)- *
CAS Registry Number 1316753-02-2; STN Entry Date 12 August 2011; 1,4,7,10-tetraazocyclotridecane-2,5,8,1-tetrone,3-(1H-indol-3-ylmethyl)-9-methyl-13-(2-methyl-13-(2-methylpropyl)-6-(6-oxooctyl)-(3S,6S,9R,13S)- *
CAS Registry Number 1349396-08-2; STN Entry Date 06 December 2011; Compound according to formula II where R8 is iso-butyl, R1 is CH2, R2 is -C(O)NH-, R3 is (CH2)5NHAc and R6 is (CH2)5C(O)CH2CH3 *
CAS Registry Number 1373504-57-4; STN Entry Date 14 May 2012; Cyclo[L-alanyl-(2S)-2-aminooctanoyl-L-tryptophyl-(3S)-3-amino-5-methylhexanoyl] *
CAS Registry Number 1373504-63-2; STN Entry Date 14 May 2012; Cyclo[L-alanyl-L-norleucyl-L-tryptophyl-(3)-3-amino-5-methylhexanoyl] *
CAS Registry Number 1373504-64-3; STN Entry Date 14 May 2012; Cyclo[L-alanyl-L-norvalyl-L-tryptophyl-(3S)-3-amino-5-methylhexanoyl] *
CAS Registry Number 1373504-65-4; STN Entry Date 14 May 2012; Cyclo[(3S)-3-amino-5-methylhexanoyl-3-methoxy-L-phenylalanyl-L-norvalyl-L-tryptophyl] *
CAS Registry Number 1373504-66-5; STN Entry Date 14 May 2012; Cyclo[(3S)-3-amino-5-methylhexanoyl-L-phenylalanyl-L-norvalyl-L-tryptophyl] *
CAS Registry Number 1373504-68-7; STN Entry Date 14 May 2012; Cyclo[(3S)-3-amino-5-methylhexanoyl-(2S)-2-phenylglycyl-L-norvalyl-L-tryptophyl] *
CAS Registry Number 1373504-69-8; STN Entry Date 14 May 2012; Cyclo[3-(3-pyridinyl)-L-alanyl-L-norvalyl-L-tryptophyl-(3S)-3-amino-5-methylhexanoyl] *
CAS Registry Number 1373504-70-1; STN Entry Date 14 May 2012; Cyclo[(3S)-3-amino-5-methylhexanoyl-L-leucyl-L-norvalyl-L-tryptophyl] *
CAS Registry Number 1373504-71-2; STN Entry Date 14 May 2012; Cyclo[D-alanyl-L-norvalyl-L-tryptophyl-(3S)-3-amino-5-methylhexanoyl] *
CAS Registry Number 1373504-72-3; STN Entry Date 14 May 2012; Cyclo[(2S)-2-aminobutanoyl-L-norvalyl-L-tryptophyl-(3S)-3-amino-5-methylhexanoyl] *
CAS Registry Number 1373504-73-4; STN Entry Date 14 May 2012; Cyclo[(3S)-3-amino-5-methylhexanoylglycyl-L-norvalyl-L-tryptophyl] *
CAS Registry Number 1373504-74-5; STN Entry Date 14 May 2012; Cyclo[(3S)-3-amino-5-methylhexanoyl-L-asparaginyl-L-norvalyl-L-tryptophyl] *
POLLICINO, T. et al. "Hepatitis B Virus Replication Is Regulated by the Acetylation Status of Hepatitis B Virus cccDNA-Bound H3 and H4 Histones" Gastroenterology (2006) vol. 130, pages 823-837 *

Also Published As

Publication number Publication date
IL235912A0 (en) 2015-01-29
US20180369323A1 (en) 2018-12-27
BR112014029697A2 (pt) 2017-08-08
US9623071B2 (en) 2017-04-18
EP2854832A4 (en) 2016-06-08
WO2013181584A2 (en) 2013-12-05
US20170296619A1 (en) 2017-10-19
HK1208823A1 (en) 2016-03-18
WO2013181584A3 (en) 2014-02-13
PH12014502659A1 (en) 2015-01-21
KR20150022911A (ko) 2015-03-04
JP2015518055A (ja) 2015-06-25
CN104507488A (zh) 2015-04-08
SG11201407970VA (en) 2014-12-30
JP6431478B2 (ja) 2018-11-28
KR101945578B1 (ko) 2019-02-07
EP2854832A2 (en) 2015-04-08
AU2013267209A1 (en) 2014-12-18
US10143720B2 (en) 2018-12-04
US20150265672A1 (en) 2015-09-24
CA2874828A1 (en) 2013-12-05
AU2017202675A1 (en) 2017-05-11

Similar Documents

Publication Publication Date Title
AU2013267209B2 (en) Modulation of hepatitis B virus cccDNA transcription
US20100226886A1 (en) Combinations of MTP Inhibitors with Cholesterol Absorption Inhibitors or Interferon for Treating Hepatitis C
CN101247807A (zh) 噻唑化合物及使用方法
US10494404B2 (en) Quinolinium conjugates of cyclosporin
US10941121B2 (en) Human helicase DDX3 inhibitors as therapeutic agents
Zhang et al. Discovery of linvencorvir (RG7907), a hepatitis B virus core protein allosteric modulator, for the treatment of chronic HBV infection
US20110117055A1 (en) Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds
Hansson et al. Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection
Stoner et al. Synthesis of HIV protease inhibitor ABT-378 (Lopinavir)
Fan et al. Inhibitors of eukaryotic translational machinery as therapeutic agents
EP2900684A2 (en) Cyclic peptides and use as medicines
Wang et al. Discovery of a novel orally bioavailable FLT3-PROTAC degrader for efficient treatment of acute myeloid leukemia and overcoming resistance of FLT3 inhibitors
Hawkins et al. Potent bactericidal antimycobacterials targeting the chaperone ClpC1 based on the depsipeptide natural products ecumicin and ohmyungsamycin A
KR102202984B1 (ko) Ns5a, ns5b 또는 ns3 억제제를 사용하여 b형 간염 바이러스 감염을 치료하는 방법
US20230074252A1 (en) Dosages and methods for treating pulmonary arterial hypertension with rodatristat
Bissegger et al. Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling
Khojasteh et al. Drug Properties
Makino et al. Discovery of a novel 9-position modified second-generation anti-HCV candidate via bioconversion and semi-synthesis of FR901459
Bardiot et al. Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor
Rolt Development of Inhibitors of Hepatitis C Virus
NZ617102B2 (en) Substituted aliphanes, cyclophanes, heteraphanes, heterophanes and hetero-heteraphanes useful for treating hcv infections
HK1116090A (en) Thiazole compounds and methods of use
NZ703894A (en) Substituted aliphanes and metallocenes useful for treating hcv infections

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired