AU2012288949B2 - Compositions having means for targeting at least one antigen to dendritic cells - Google Patents

Compositions having means for targeting at least one antigen to dendritic cells Download PDF

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Publication number
AU2012288949B2
AU2012288949B2 AU2012288949A AU2012288949A AU2012288949B2 AU 2012288949 B2 AU2012288949 B2 AU 2012288949B2 AU 2012288949 A AU2012288949 A AU 2012288949A AU 2012288949 A AU2012288949 A AU 2012288949A AU 2012288949 B2 AU2012288949 B2 AU 2012288949B2
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AU
Australia
Prior art keywords
antigen
toxin
dendritic cells
cpg
combined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012288949A
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English (en)
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AU2012288949A1 (en
Inventor
Ludger Johannes
Eric Tartour
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Institut Curie
Universite Paris Descartes
Original Assignee
Centre National de la Recherche Scientifique CNRS
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Institut Curie
Universite Paris Descartes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Assistance Publique Hopitaux de Paris APHP, Institut National de la Sante et de la Recherche Medicale INSERM, Institut Curie, Universite Paris Descartes filed Critical Centre National de la Recherche Scientifique CNRS
Publication of AU2012288949A1 publication Critical patent/AU2012288949A1/en
Assigned to INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, UNIVERSITE PARIS DESCARTES reassignment INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Amend patent request/document other than specification (104) Assignors: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE RENE DESCARTES
Application granted granted Critical
Publication of AU2012288949B2 publication Critical patent/AU2012288949B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • A61K39/001106Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6056Antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
AU2012288949A 2011-07-22 2012-07-23 Compositions having means for targeting at least one antigen to dendritic cells Ceased AU2012288949B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11305959.6 2011-07-22
EP11305959A EP2548571A1 (en) 2011-07-22 2011-07-22 Compositions having means for targeting at least one antigen to dendritic cells
PCT/EP2012/064425 WO2013014128A1 (en) 2011-07-22 2012-07-23 Compositions having means for targeting at least one antigen to dendritic cells

Publications (2)

Publication Number Publication Date
AU2012288949A1 AU2012288949A1 (en) 2013-04-11
AU2012288949B2 true AU2012288949B2 (en) 2014-05-01

Family

ID=46548478

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012288949A Ceased AU2012288949B2 (en) 2011-07-22 2012-07-23 Compositions having means for targeting at least one antigen to dendritic cells

Country Status (9)

Country Link
US (2) US20140199379A1 (enExample)
EP (2) EP2548571A1 (enExample)
JP (1) JP2014523918A (enExample)
CN (1) CN103796674A (enExample)
AU (1) AU2012288949B2 (enExample)
CA (1) CA2841036A1 (enExample)
IL (1) IL230525A0 (enExample)
IN (1) IN2014DN00078A (enExample)
WO (1) WO2013014128A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2953287A1 (en) * 2013-06-19 2014-12-24 Massachusetts Institute Of Technology In vivo targeting of cells with ligand-conjugated particles
WO2015013673A1 (en) 2013-07-25 2015-01-29 Aurasense Therapeutics, Llc Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
AU2015269412B2 (en) 2014-06-04 2020-03-12 Exicure Operating Company Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
CN104277094A (zh) * 2014-07-04 2015-01-14 文康医疗技术(深圳)有限公司 Dc靶向肽及其应用
US11213593B2 (en) 2014-11-21 2022-01-04 Northwestern University Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
CA2986687A1 (en) * 2015-05-22 2016-12-01 Brian J. Czerniecki Manufacturing multi-dose injection ready dendritic cell vaccines
WO2016199904A1 (ja) * 2015-06-10 2016-12-15 国立大学法人東京大学 ワクチン用アジュバント、ワクチン、及び免疫誘導方法
US20190010236A1 (en) * 2015-12-29 2019-01-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for dectin-2 stimulation and cancer immunotherapy
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
US11491114B2 (en) * 2016-10-12 2022-11-08 Curioralrx, Llc Formulations for enteric delivery of therapeutic agents
WO2018201090A1 (en) 2017-04-28 2018-11-01 Exicure, Inc. Synthesis of spherical nucleic acids using lipophilic moieties
WO2018203833A1 (en) * 2017-05-03 2018-11-08 Agency For Science, Technology And Research Methods for the stimulation of dendritic cell (dc) precursor population "pre-dc" and their uses thereof
WO2020245321A1 (en) * 2019-06-04 2020-12-10 Institut Curie METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
WO2023070317A1 (zh) * 2021-10-26 2023-05-04 江苏省农业科学院 基于dc细胞的双功能纳米抗体及其构建方法和应用
CN115724992A (zh) * 2022-07-25 2023-03-03 江南大学 一种志贺毒素b亚基与抗原偶联物及其制备方法与应用
GB202411940D0 (en) * 2024-08-13 2024-09-25 Univ Exeter Anti-CLEC12A Antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766193B1 (fr) 1997-07-18 2001-09-14 Inst Curie Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique
EP1229045A1 (en) 2001-02-01 2002-08-07 Institut Curie Universal carrier for targeting molecules to Gb3 receptor expressing cells
GB0524409D0 (en) 2005-11-30 2006-01-11 Glaxosmithkline Biolog Sa Vaccines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BENOIT VINGERT ET AL, EUROPEAN JOURNAL OF IMMUNOLOGY, VOL. 36, NO 5, 1 MAY 2006, PAGES 1124-1135 *

Also Published As

Publication number Publication date
IN2014DN00078A (enExample) 2015-05-15
CA2841036A1 (en) 2013-01-31
CN103796674A (zh) 2014-05-14
AU2012288949A1 (en) 2013-04-11
EP2734225A1 (en) 2014-05-28
US20140199379A1 (en) 2014-07-17
US20170042994A1 (en) 2017-02-16
JP2014523918A (ja) 2014-09-18
EP2548571A1 (en) 2013-01-23
WO2013014128A1 (en) 2013-01-31
IL230525A0 (en) 2014-03-31

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