AU2012282402B2 - Antibodies to phosphorylated tau aggregates - Google Patents

Antibodies to phosphorylated tau aggregates Download PDF

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Publication number
AU2012282402B2
AU2012282402B2 AU2012282402A AU2012282402A AU2012282402B2 AU 2012282402 B2 AU2012282402 B2 AU 2012282402B2 AU 2012282402 A AU2012282402 A AU 2012282402A AU 2012282402 A AU2012282402 A AU 2012282402A AU 2012282402 B2 AU2012282402 B2 AU 2012282402B2
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AU
Australia
Prior art keywords
antibody
tau
seq
amino acid
acid sequence
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Ceased
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AU2012282402A
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English (en)
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AU2012282402A1 (en
AU2012282402A2 (en
Inventor
Fred Van Leuven
Eugeen Vanmechelen
Joris Winderickx
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Katholieke Universiteit Leuven
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Katholieke Universiteit Leuven
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
AU2012282402A 2011-07-14 2012-07-16 Antibodies to phosphorylated tau aggregates Ceased AU2012282402B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1112056.5A GB201112056D0 (en) 2011-07-14 2011-07-14 Antibodies
GB1112056.5 2011-07-14
PCT/EP2012/063924 WO2013007839A1 (en) 2011-07-14 2012-07-16 Antibodies to phosphorylated tau aggregates

Publications (3)

Publication Number Publication Date
AU2012282402A1 AU2012282402A1 (en) 2014-01-30
AU2012282402A2 AU2012282402A2 (en) 2014-05-08
AU2012282402B2 true AU2012282402B2 (en) 2017-03-09

Family

ID=44586547

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012282402A Ceased AU2012282402B2 (en) 2011-07-14 2012-07-16 Antibodies to phosphorylated tau aggregates

Country Status (6)

Country Link
US (1) US9447179B2 (cg-RX-API-DMAC7.html)
EP (1) EP2731969B1 (cg-RX-API-DMAC7.html)
JP (1) JP6168364B2 (cg-RX-API-DMAC7.html)
AU (1) AU2012282402B2 (cg-RX-API-DMAC7.html)
GB (1) GB201112056D0 (cg-RX-API-DMAC7.html)
WO (1) WO2013007839A1 (cg-RX-API-DMAC7.html)

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AU2013302540B2 (en) * 2012-08-16 2018-02-15 Ipierian, Inc. Methods of treating a tauopathy
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CN105121465B (zh) * 2013-03-13 2020-09-08 普罗塞纳生物科技公司 Tau免疫疗法
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WO2015081085A2 (en) * 2013-11-27 2015-06-04 Ipierian, Inc. Methods of treating a tauopathy
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EP2899208A1 (en) * 2014-01-28 2015-07-29 F.Hoffmann-La Roche Ag Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof
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AR100978A1 (es) 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
TW202136296A (zh) 2014-06-27 2021-10-01 美商C2N醫療診斷有限責任公司 人類化抗-tau抗體
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WO2016207245A1 (en) * 2015-06-24 2016-12-29 F. Hoffmann-La Roche Ag Humanized anti-tau(ps422) antibodies and methods of use
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US10364286B2 (en) * 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
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Also Published As

Publication number Publication date
AU2012282402A1 (en) 2014-01-30
AU2012282402A2 (en) 2014-05-08
WO2013007839A1 (en) 2013-01-17
US20140161875A1 (en) 2014-06-12
EP2731969A1 (en) 2014-05-21
EP2731969B1 (en) 2018-10-17
GB201112056D0 (en) 2011-08-31
JP2014523742A (ja) 2014-09-18
JP6168364B2 (ja) 2017-07-26
US9447179B2 (en) 2016-09-20

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