AU2012273987B2 - Binding domains directed against GPCR:G protein complexes and uses derived thereof - Google Patents

Binding domains directed against GPCR:G protein complexes and uses derived thereof Download PDF

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Publication number
AU2012273987B2
AU2012273987B2 AU2012273987A AU2012273987A AU2012273987B2 AU 2012273987 B2 AU2012273987 B2 AU 2012273987B2 AU 2012273987 A AU2012273987 A AU 2012273987A AU 2012273987 A AU2012273987 A AU 2012273987A AU 2012273987 B2 AU2012273987 B2 AU 2012273987B2
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Prior art keywords
protein
gpcr
complex
binding
receptor
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AU2012273987A1 (en
Inventor
Sebastien Granier
Brian Kobilka
Toon Laeremans
Els Pardon
Soren Rasmussen
Jan Steyaert
Roger K. Sunahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vlaams Instituut voor Biotechnologie VIB
Vrije Universiteit Brussel VUB
University of Michigan System
Leland Stanford Junior University
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Vlaams Instituut voor Biotechnologie VIB
Vrije Universiteit Brussel VUB
University of Michigan System
Leland Stanford Junior University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2012273987A 2011-06-21 2012-06-21 Binding domains directed against GPCR:G protein complexes and uses derived thereof Active AU2012273987B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161571159P 2011-06-21 2011-06-21
US61/571,159 2011-06-21
EP11181357 2011-09-15
EP11181357.2 2011-09-15
PCT/EP2012/062036 WO2012175643A2 (en) 2011-06-21 2012-06-21 Binding domains directed against gpcr:g protein complexes and uses derived thereof

Publications (2)

Publication Number Publication Date
AU2012273987A1 AU2012273987A1 (en) 2014-01-30
AU2012273987B2 true AU2012273987B2 (en) 2017-01-05

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US (4) US9695227B2 (cg-RX-API-DMAC7.html)
EP (3) EP4282882A3 (cg-RX-API-DMAC7.html)
JP (2) JP6164535B2 (cg-RX-API-DMAC7.html)
CN (2) CN104053667B (cg-RX-API-DMAC7.html)
AU (1) AU2012273987B2 (cg-RX-API-DMAC7.html)
CA (1) CA2839834A1 (cg-RX-API-DMAC7.html)
DK (1) DK2723764T3 (cg-RX-API-DMAC7.html)
ES (1) ES2662372T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20180443T1 (cg-RX-API-DMAC7.html)
HU (1) HUE036982T2 (cg-RX-API-DMAC7.html)
NO (1) NO2723764T3 (cg-RX-API-DMAC7.html)
PL (1) PL2723764T3 (cg-RX-API-DMAC7.html)
PT (1) PT2723764T (cg-RX-API-DMAC7.html)
WO (1) WO2012175643A2 (cg-RX-API-DMAC7.html)

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JP6164535B2 (ja) 2017-07-19
CN104053667B (zh) 2017-09-15
CA2839834A1 (en) 2012-12-27
US20170253644A1 (en) 2017-09-07
PL2723764T3 (pl) 2018-05-30
US20140275487A1 (en) 2014-09-18
CN104053667A (zh) 2014-09-17
US10626154B2 (en) 2020-04-21
EP3345919A1 (en) 2018-07-11
BR112013032451A2 (pt) 2016-11-22
WO2012175643A2 (en) 2012-12-27
AU2012273987A1 (en) 2014-01-30
HUE036982T2 (hu) 2018-08-28
ES2662372T3 (es) 2018-04-06
NO2723764T3 (cg-RX-API-DMAC7.html) 2018-05-26
US20200239534A1 (en) 2020-07-30
DK2723764T3 (en) 2018-03-12
US12252521B2 (en) 2025-03-18
JP2017127306A (ja) 2017-07-27
PT2723764T (pt) 2018-03-09
EP4282882A3 (en) 2024-03-06
WO2012175643A3 (en) 2013-06-13
CN107857810A (zh) 2018-03-30
US9695227B2 (en) 2017-07-04
EP2723764A2 (en) 2014-04-30
JP2014525735A (ja) 2014-10-02
EP2723764B1 (en) 2017-12-27
US20250171510A1 (en) 2025-05-29
EP4282882A2 (en) 2023-11-29
HRP20180443T1 (hr) 2018-04-20

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