AU2012245439B2 - Endoglin polypeptides and uses thereof - Google Patents

Endoglin polypeptides and uses thereof Download PDF

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Publication number
AU2012245439B2
AU2012245439B2 AU2012245439A AU2012245439A AU2012245439B2 AU 2012245439 B2 AU2012245439 B2 AU 2012245439B2 AU 2012245439 A AU2012245439 A AU 2012245439A AU 2012245439 A AU2012245439 A AU 2012245439A AU 2012245439 B2 AU2012245439 B2 AU 2012245439B2
Authority
AU
Australia
Prior art keywords
eng
seq
polypeptide
heng
endoglin polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012245439A
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English (en)
Other versions
AU2012245439A1 (en
Inventor
Roselyne CASTONGUAY
Asya Grinberg
Ravindra Kumar
Eric Werner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acceleron Pharma Inc
Original Assignee
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of AU2012245439A1 publication Critical patent/AU2012245439A1/en
Priority to AU2017201711A priority Critical patent/AU2017201711B2/en
Application granted granted Critical
Publication of AU2012245439B2 publication Critical patent/AU2012245439B2/en
Priority to AU2019204979A priority patent/AU2019204979B2/en
Priority to AU2020244456A priority patent/AU2020244456A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2012245439A 2011-04-20 2012-04-19 Endoglin polypeptides and uses thereof Ceased AU2012245439B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2017201711A AU2017201711B2 (en) 2011-04-20 2017-03-13 Endoglin polypeptides and uses thereof
AU2019204979A AU2019204979B2 (en) 2011-04-20 2019-07-11 Endoglin polypeptides and uses thereof
AU2020244456A AU2020244456A1 (en) 2011-04-20 2020-09-30 Endoglin polypeptides and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477585P 2011-04-20 2011-04-20
US61/477,585 2011-04-20
PCT/US2012/034295 WO2012145539A1 (en) 2011-04-20 2012-04-19 Endoglin polypeptides and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017201711A Division AU2017201711B2 (en) 2011-04-20 2017-03-13 Endoglin polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
AU2012245439A1 AU2012245439A1 (en) 2013-11-28
AU2012245439B2 true AU2012245439B2 (en) 2017-04-06

Family

ID=46000405

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2012245439A Ceased AU2012245439B2 (en) 2011-04-20 2012-04-19 Endoglin polypeptides and uses thereof
AU2017201711A Ceased AU2017201711B2 (en) 2011-04-20 2017-03-13 Endoglin polypeptides and uses thereof
AU2019204979A Ceased AU2019204979B2 (en) 2011-04-20 2019-07-11 Endoglin polypeptides and uses thereof
AU2020244456A Abandoned AU2020244456A1 (en) 2011-04-20 2020-09-30 Endoglin polypeptides and uses thereof

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2017201711A Ceased AU2017201711B2 (en) 2011-04-20 2017-03-13 Endoglin polypeptides and uses thereof
AU2019204979A Ceased AU2019204979B2 (en) 2011-04-20 2019-07-11 Endoglin polypeptides and uses thereof
AU2020244456A Abandoned AU2020244456A1 (en) 2011-04-20 2020-09-30 Endoglin polypeptides and uses thereof

Country Status (8)

Country Link
US (3) US9932386B2 (enExample)
EP (2) EP2699590B8 (enExample)
JP (3) JP6250533B2 (enExample)
CN (3) CN108178789B (enExample)
AU (4) AU2012245439B2 (enExample)
CA (1) CA2833747C (enExample)
DK (1) DK2699590T3 (enExample)
WO (1) WO2012145539A1 (enExample)

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US8221753B2 (en) 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
CN108178789B (zh) 2011-04-20 2021-11-02 阿塞勒隆制药公司 内皮糖蛋白多肽及其用途
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WO2015042269A1 (en) * 2013-09-20 2015-03-26 Tufts Medical Center, Inc. Methods and compositions for reducing cardiac damage and other conditions
EP3851118A1 (en) * 2013-10-25 2021-07-21 Acceleron Pharma Inc. Endoglin peptides to treat fibrotic diseases
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EP3735418A4 (en) * 2018-01-03 2021-11-10 Acceleron Pharma Inc. ONE-ARMED CO-RECEPTOR FUSION PROTEINS AND USES THEREOF
CN109402127B (zh) * 2018-09-29 2021-12-10 复旦大学附属眼耳鼻喉科医院 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用
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EP4081240A4 (en) * 2019-12-03 2023-12-06 Acceleron Pharma Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF PULMONARY HYPERTENSION
US20230075244A1 (en) * 2020-02-20 2023-03-09 The Feinstein Institutes For Medical Research Agonist antibodies against endoglin and uses thereof
KR20220021207A (ko) * 2020-08-13 2022-02-22 주식회사 나이벡 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물
US20220233714A1 (en) * 2021-01-27 2022-07-28 Vanderbilt University Nanogold-dna bioconjugates and methods of use thereof

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Also Published As

Publication number Publication date
EP2699590B8 (en) 2019-04-17
JP7097930B2 (ja) 2022-07-08
AU2019204979A1 (en) 2019-08-01
EP2699590B1 (en) 2019-02-20
JP6803315B2 (ja) 2020-12-23
CA2833747C (en) 2022-10-18
CN103781798A (zh) 2014-05-07
CN108178789A (zh) 2018-06-19
CN108178789B (zh) 2021-11-02
JP6250533B2 (ja) 2017-12-20
US20150307588A1 (en) 2015-10-29
EP2699590A1 (en) 2014-02-26
WO2012145539A1 (en) 2012-10-26
EP3549952A1 (en) 2019-10-09
AU2012245439A1 (en) 2013-11-28
CN103781798B (zh) 2018-03-13
AU2020244456A1 (en) 2020-10-29
JP2014513951A (ja) 2014-06-19
AU2017201711A1 (en) 2017-04-13
US10981972B2 (en) 2021-04-20
DK2699590T3 (en) 2019-05-06
US20210300991A1 (en) 2021-09-30
AU2019204979B2 (en) 2020-07-16
US20180258156A1 (en) 2018-09-13
CA2833747A1 (en) 2012-10-26
CN108341863A (zh) 2018-07-31
JP2020202844A (ja) 2020-12-24
US9932386B2 (en) 2018-04-03
JP2018070625A (ja) 2018-05-10
AU2017201711B2 (en) 2019-04-18

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