AU2012205599B2 - Use of a VEGF antagonist to treat angiogenic eye disorders - Google Patents

Use of a VEGF antagonist to treat angiogenic eye disorders Download PDF

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Publication number
AU2012205599B2
AU2012205599B2 AU2012205599A AU2012205599A AU2012205599B2 AU 2012205599 B2 AU2012205599 B2 AU 2012205599B2 AU 2012205599 A AU2012205599 A AU 2012205599A AU 2012205599 A AU2012205599 A AU 2012205599A AU 2012205599 B2 AU2012205599 B2 AU 2012205599B2
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Prior art keywords
vegf antagonist
administered
dose
doses
vegf
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AU2012205599A1 (en
Inventor
George D. Yancopoulos
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
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Application granted granted Critical
Publication of AU2012205599B2 publication Critical patent/AU2012205599B2/en
Priority to AU2017200290A priority Critical patent/AU2017200290B2/en
Priority to AU2019202260A priority patent/AU2019202260A1/en
Priority to AU2021200935A priority patent/AU2021200935A1/en
Priority to AU2024204677A priority patent/AU2024204677A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AU2012205599A 2011-01-13 2012-01-11 Use of a VEGF antagonist to treat angiogenic eye disorders Active AU2012205599B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2017200290A AU2017200290B2 (en) 2011-01-13 2017-01-17 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2019202260A AU2019202260A1 (en) 2011-01-13 2019-04-02 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2021200935A AU2021200935A1 (en) 2011-01-13 2021-02-12 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2024204677A AU2024204677A1 (en) 2011-01-13 2024-07-05 Use of a VEGF antagonist to treat angiogenic eye disorders

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161432245P 2011-01-13 2011-01-13
US61/432,245 2011-01-13
US201161434836P 2011-01-21 2011-01-21
US61/434,836 2011-01-21
US201161561957P 2011-11-21 2011-11-21
US61/561,957 2011-11-21
PCT/US2012/020855 WO2012097019A1 (en) 2011-01-13 2012-01-11 Use of a vegf antagonist to treat angiogenic eye disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017200290A Division AU2017200290B2 (en) 2011-01-13 2017-01-17 Use of a VEGF antagonist to treat angiogenic eye disorders

Publications (2)

Publication Number Publication Date
AU2012205599A1 AU2012205599A1 (en) 2013-07-18
AU2012205599B2 true AU2012205599B2 (en) 2016-10-20

Family

ID=45507924

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2012205599A Active AU2012205599B2 (en) 2011-01-13 2012-01-11 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2017200290A Active AU2017200290B2 (en) 2011-01-13 2017-01-17 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2019202260A Abandoned AU2019202260A1 (en) 2011-01-13 2019-04-02 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2021200935A Abandoned AU2021200935A1 (en) 2011-01-13 2021-02-12 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2024204677A Pending AU2024204677A1 (en) 2011-01-13 2024-07-05 Use of a VEGF antagonist to treat angiogenic eye disorders

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2017200290A Active AU2017200290B2 (en) 2011-01-13 2017-01-17 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2019202260A Abandoned AU2019202260A1 (en) 2011-01-13 2019-04-02 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2021200935A Abandoned AU2021200935A1 (en) 2011-01-13 2021-02-12 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2024204677A Pending AU2024204677A1 (en) 2011-01-13 2024-07-05 Use of a VEGF antagonist to treat angiogenic eye disorders

Country Status (13)

Country Link
US (14) US9254338B2 (https=)
EP (4) EP4360709A3 (https=)
JP (6) JP2014503555A (https=)
KR (8) KR20190049934A (https=)
CN (1) CN103533950A (https=)
AU (5) AU2012205599B2 (https=)
BR (1) BR112013017752A8 (https=)
CA (1) CA2824422A1 (https=)
HK (1) HK1244693A1 (https=)
IL (3) IL295359A (https=)
MX (3) MX385629B (https=)
SG (4) SG191334A1 (https=)
WO (1) WO2012097019A1 (https=)

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