AU2011379972B2 - Cysteamine in the treatment of fibrotic disease - Google Patents

Cysteamine in the treatment of fibrotic disease Download PDF

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Publication number
AU2011379972B2
AU2011379972B2 AU2011379972A AU2011379972A AU2011379972B2 AU 2011379972 B2 AU2011379972 B2 AU 2011379972B2 AU 2011379972 A AU2011379972 A AU 2011379972A AU 2011379972 A AU2011379972 A AU 2011379972A AU 2011379972 B2 AU2011379972 B2 AU 2011379972B2
Authority
AU
Australia
Prior art keywords
antagonist
cysteamine
receptor
fibrosis
interstitial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU2011379972A
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English (en)
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AU2011379972A1 (en
Inventor
Allison A. Eddy
Daryl M. Okamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seattle Childrens Hospital
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Seattle Childrens Hospital
Seattle Childrens Research Institute
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Filing date
Publication date
Application filed by Seattle Childrens Hospital, Seattle Childrens Research Institute filed Critical Seattle Childrens Hospital
Publication of AU2011379972A1 publication Critical patent/AU2011379972A1/en
Application granted granted Critical
Publication of AU2011379972B2 publication Critical patent/AU2011379972B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2011379972A 2011-10-26 2011-10-26 Cysteamine in the treatment of fibrotic disease Expired - Fee Related AU2011379972B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/057935 WO2013062544A1 (en) 2011-10-26 2011-10-26 Cysteamine in the treatment of fibrotic disease

Publications (2)

Publication Number Publication Date
AU2011379972A1 AU2011379972A1 (en) 2014-05-15
AU2011379972B2 true AU2011379972B2 (en) 2016-05-12

Family

ID=48168215

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011379972A Expired - Fee Related AU2011379972B2 (en) 2011-10-26 2011-10-26 Cysteamine in the treatment of fibrotic disease

Country Status (7)

Country Link
US (2) US9468612B2 (enExample)
AU (1) AU2011379972B2 (enExample)
BR (1) BR112014009789A2 (enExample)
CA (1) CA2853484C (enExample)
IN (1) IN2014DN03049A (enExample)
MX (1) MX2014004994A (enExample)
WO (1) WO2013062544A1 (enExample)

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JP2018525350A (ja) 2015-07-02 2018-09-06 ホライズン オルファン エルエルシー Ａｄｏ耐性システアミン類似体およびその使用
IL261756B2 (en) * 2016-03-17 2023-11-01 Thiogenesis Therapeutics Inc Preparations for the controlled release of cysteamine and systemic treatment of disorders sensitive to cysteamine
US10155948B2 (en) * 2016-05-12 2018-12-18 Kangwon National University University-Industry Cooperation Foundation and Pharmaceutical composition for preventing or treating diabetic complications and screening method for preventive or therapeutic agent for diabetic complications
GB201609940D0 (en) * 2016-06-07 2016-07-20 Novabiotics Ltd Microparticles
US10905660B2 (en) 2016-06-07 2021-02-02 Novabiotics Limited Microparticles
WO2018148254A1 (en) * 2017-02-07 2018-08-16 Children's Hospital Medical Center Treatment of asthma with cysteamine
ES3024932T3 (en) 2017-09-20 2025-06-05 Thiogenesis Therapeutics Inc Compounds for the treatment of cysteamine sensitive disorders
US10828372B2 (en) 2017-11-10 2020-11-10 Wisconsin Alumni Research Foundation Compositions and methods for the inhibition of fibrosis
WO2020079186A1 (en) 2018-10-17 2020-04-23 Novabiotics Limited Dosage regime
US20220177918A1 (en) * 2019-04-12 2022-06-09 The Regents Of The University Of California Methods for treating inherited eye defects
US12263144B2 (en) * 2020-10-13 2025-04-01 Accubit LLC—Biotechnology Methods of treating IgA nephropathy with thiol-containing molecules

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Also Published As

Publication number Publication date
AU2011379972A1 (en) 2014-05-15
MX2014004994A (es) 2014-08-27
BR112014009789A2 (pt) 2017-04-25
US20140275279A1 (en) 2014-09-18
US9468612B2 (en) 2016-10-18
WO2013062544A1 (en) 2013-05-02
US20170165207A1 (en) 2017-06-15
CA2853484A1 (en) 2013-05-02
CA2853484C (en) 2018-08-21
IN2014DN03049A (enExample) 2015-05-15
US9925154B2 (en) 2018-03-27

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