AU2011344865B2 - Entrapment of radionuclides in nanoparticle compositions - Google Patents

Entrapment of radionuclides in nanoparticle compositions Download PDF

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Publication number
AU2011344865B2
AU2011344865B2 AU2011344865A AU2011344865A AU2011344865B2 AU 2011344865 B2 AU2011344865 B2 AU 2011344865B2 AU 2011344865 A AU2011344865 A AU 2011344865A AU 2011344865 A AU2011344865 A AU 2011344865A AU 2011344865 B2 AU2011344865 B2 AU 2011344865B2
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AU
Australia
Prior art keywords
lll
loading
nanoparticles
nanoparticle composition
leakage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011344865A
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English (en)
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AU2011344865A1 (en
Inventor
Thomas Lars Andresen
Jonas Rosager Henriksen
Andreas Kjaer
Anncatrine Luisa Petersen
Palle Hedengran Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rigshospitalet
Danmarks Tekniske Universitet
Original Assignee
Rigshospitalet
Danmarks Tekniske Universitet
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Publication date
Application filed by Rigshospitalet, Danmarks Tekniske Universitet filed Critical Rigshospitalet
Publication of AU2011344865A1 publication Critical patent/AU2011344865A1/en
Application granted granted Critical
Publication of AU2011344865B2 publication Critical patent/AU2011344865B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes
    • A61K51/1237—Polymersomes, i.e. liposomes with polymerisable or polymerized bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1203—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules in a form not provided for by groups A61K51/1206 - A61K51/1296, e.g. cells, cell fragments, viruses, virus capsides, ghosts, red blood cells, viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0408—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nuclear Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2011344865A 2010-12-14 2011-12-14 Entrapment of radionuclides in nanoparticle compositions Ceased AU2011344865B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA201070542 2010-12-14
DKPA201070542 2010-12-14
US201161434070P 2011-01-19 2011-01-19
EP11151372.7 2011-01-19
US61/434,070 2011-01-19
EP11151372 2011-01-19
PCT/DK2011/050479 WO2012079582A1 (en) 2010-12-14 2011-12-14 Entrapment of radionuclides in nanoparticle compositions

Publications (2)

Publication Number Publication Date
AU2011344865A1 AU2011344865A1 (en) 2013-07-11
AU2011344865B2 true AU2011344865B2 (en) 2017-03-09

Family

ID=45445682

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011344865A Ceased AU2011344865B2 (en) 2010-12-14 2011-12-14 Entrapment of radionuclides in nanoparticle compositions

Country Status (10)

Country Link
US (2) US9226984B2 (enExample)
EP (1) EP2651447B1 (enExample)
JP (1) JP5947807B2 (enExample)
KR (1) KR20140092226A (enExample)
AU (1) AU2011344865B2 (enExample)
BR (1) BR112013014735A2 (enExample)
CA (1) CA2821024A1 (enExample)
DK (1) DK2651447T3 (enExample)
RU (1) RU2013132610A (enExample)
WO (1) WO2012079582A1 (enExample)

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JP6245481B2 (ja) 2012-04-17 2017-12-13 メリマック ファーマシューティカルズ インコーポレーティッド 非侵襲的イメージングのための組成物および方法
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9993427B2 (en) * 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
US20160303264A1 (en) * 2013-10-23 2016-10-20 Merrimack Pharmaceuticals, Inc. Liposomes useful for non-invasive imaging and drug delivery
TW201615229A (zh) * 2014-10-23 2016-05-01 行政院原子能委員會核能研究所 製備放射標靶藥物的套件及放射標靶藥物之製造方法
MX381655B (es) 2015-05-04 2025-03-13 Versantis AG Metodo para preparar vesiculas con gradiente de ph de transmembrana.
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
AU2016309002B2 (en) 2015-08-20 2021-07-29 Ipsen Biopharm Ltd. Combination therapy using liposomal irinotecan and a PARP inhibitor for cancer treatment
HK1257220A1 (zh) 2015-08-21 2019-10-18 益普生生物制药有限公司 使用包含脂质体伊立替康和奥沙利铂的组合疗法治疗转移性胰腺癌的方法
RU2599462C1 (ru) * 2015-09-22 2016-10-10 Общество с ограниченной ответственностью "БИОТЕХНОЛОГИЯ" (ООО "БИОТЕХНОЛОГИЯ") Способ полисигнальной активации апоптоза клеток злокачественных солидных опухолей
RS67289B1 (sr) 2015-10-16 2025-11-28 Ipsen Biopharm Ltd Stabilizacija farmaceutskih kompozicija kamptotecina
EP3354270A4 (en) * 2016-10-21 2019-04-24 Obshestvo S Ogranichennoi Otvetstvennost'yu "Biotehnologiya" METHOD FOR ACTIVATION OF APOPTOSIS OF CELLS WITH MULTIPLE SIGNALING OF SOLID MALIGNANT TUMORS
EP3535026A1 (en) 2016-11-02 2019-09-11 Ipsen Biopharm Limited Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin)
EP3773996A4 (en) 2018-03-26 2022-03-30 Triumf Systems, apparatus and methods for separating actinium, radium, and thorium
CN109063231B (zh) * 2018-06-15 2023-06-27 中国核电工程有限公司 基于GUM导则的核素不确定度对临界系统keff影响的评定方法
US20220118116A1 (en) * 2019-01-29 2022-04-21 The Johns Hopkins University Adhesive/adsorption switch on nanoparticles to increase tumor uptake and delay tumor clearance
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
US20250206704A1 (en) * 2022-03-24 2025-06-26 The Brigham And Women's Hospital, Inc. Engineered ionophores for transport of metal ions
WO2024258223A1 (ko) * 2023-06-14 2024-12-19 주식회사 지티아이바이오사이언스 방사성 동위원소를 포함하는 나노입자 조성물을 제조하는 장치 및 이의 제조 방법
FR3156312A1 (fr) * 2023-12-08 2025-06-13 Aken Medical Nanoparticules radioactives de type cœur/enveloppes utiles en radiothérapie ciblée
FR3156311A1 (fr) * 2023-12-08 2025-06-13 Aken Medical Nanoparticules radioactives de type cœur/enveloppe utiles en radiothérapie ciblée

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Also Published As

Publication number Publication date
KR20140092226A (ko) 2014-07-23
WO2012079582A1 (en) 2012-06-21
RU2013132610A (ru) 2015-01-20
US20130251630A1 (en) 2013-09-26
US9226984B2 (en) 2016-01-05
AU2011344865A1 (en) 2013-07-11
US20160158392A1 (en) 2016-06-09
EP2651447B1 (en) 2018-08-29
DK2651447T3 (en) 2018-12-17
BR112013014735A2 (pt) 2016-10-04
EP2651447A1 (en) 2013-10-23
JP5947807B2 (ja) 2016-07-06
JP2014506240A (ja) 2014-03-13
CA2821024A1 (en) 2012-06-21

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