KR20140092226A - 나노입자 조성물에서 방사성 핵종의 포집 - Google Patents
나노입자 조성물에서 방사성 핵종의 포집 Download PDFInfo
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- KR20140092226A KR20140092226A KR1020137017922A KR20137017922A KR20140092226A KR 20140092226 A KR20140092226 A KR 20140092226A KR 1020137017922 A KR1020137017922 A KR 1020137017922A KR 20137017922 A KR20137017922 A KR 20137017922A KR 20140092226 A KR20140092226 A KR 20140092226A
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- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0408—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Nuclear Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
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| DKPA201070542 | 2010-12-14 | ||
| DKPA201070542 | 2010-12-14 | ||
| US201161434070P | 2011-01-19 | 2011-01-19 | |
| EP11151372.7 | 2011-01-19 | ||
| US61/434,070 | 2011-01-19 | ||
| EP11151372 | 2011-01-19 | ||
| PCT/DK2011/050479 WO2012079582A1 (en) | 2010-12-14 | 2011-12-14 | Entrapment of radionuclides in nanoparticle compositions |
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| KR20140092226A true KR20140092226A (ko) | 2014-07-23 |
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| US (2) | US9226984B2 (enExample) |
| EP (1) | EP2651447B1 (enExample) |
| JP (1) | JP5947807B2 (enExample) |
| KR (1) | KR20140092226A (enExample) |
| AU (1) | AU2011344865B2 (enExample) |
| BR (1) | BR112013014735A2 (enExample) |
| CA (1) | CA2821024A1 (enExample) |
| DK (1) | DK2651447T3 (enExample) |
| RU (1) | RU2013132610A (enExample) |
| WO (1) | WO2012079582A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024258223A1 (ko) * | 2023-06-14 | 2024-12-19 | 주식회사 지티아이바이오사이언스 | 방사성 동위원소를 포함하는 나노입자 조성물을 제조하는 장치 및 이의 제조 방법 |
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| JP6245481B2 (ja) | 2012-04-17 | 2017-12-13 | メリマック ファーマシューティカルズ インコーポレーティッド | 非侵襲的イメージングのための組成物および方法 |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9993427B2 (en) * | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
| US20160303264A1 (en) * | 2013-10-23 | 2016-10-20 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for non-invasive imaging and drug delivery |
| TW201615229A (zh) * | 2014-10-23 | 2016-05-01 | 行政院原子能委員會核能研究所 | 製備放射標靶藥物的套件及放射標靶藥物之製造方法 |
| MX381655B (es) | 2015-05-04 | 2025-03-13 | Versantis AG | Metodo para preparar vesiculas con gradiente de ph de transmembrana. |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| AU2016309002B2 (en) | 2015-08-20 | 2021-07-29 | Ipsen Biopharm Ltd. | Combination therapy using liposomal irinotecan and a PARP inhibitor for cancer treatment |
| HK1257220A1 (zh) | 2015-08-21 | 2019-10-18 | 益普生生物制药有限公司 | 使用包含脂质体伊立替康和奥沙利铂的组合疗法治疗转移性胰腺癌的方法 |
| RU2599462C1 (ru) * | 2015-09-22 | 2016-10-10 | Общество с ограниченной ответственностью "БИОТЕХНОЛОГИЯ" (ООО "БИОТЕХНОЛОГИЯ") | Способ полисигнальной активации апоптоза клеток злокачественных солидных опухолей |
| RS67289B1 (sr) | 2015-10-16 | 2025-11-28 | Ipsen Biopharm Ltd | Stabilizacija farmaceutskih kompozicija kamptotecina |
| EP3354270A4 (en) * | 2016-10-21 | 2019-04-24 | Obshestvo S Ogranichennoi Otvetstvennost'yu "Biotehnologiya" | METHOD FOR ACTIVATION OF APOPTOSIS OF CELLS WITH MULTIPLE SIGNALING OF SOLID MALIGNANT TUMORS |
| EP3535026A1 (en) | 2016-11-02 | 2019-09-11 | Ipsen Biopharm Limited | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
| EP3773996A4 (en) | 2018-03-26 | 2022-03-30 | Triumf | Systems, apparatus and methods for separating actinium, radium, and thorium |
| CN109063231B (zh) * | 2018-06-15 | 2023-06-27 | 中国核电工程有限公司 | 基于GUM导则的核素不确定度对临界系统keff影响的评定方法 |
| US20220118116A1 (en) * | 2019-01-29 | 2022-04-21 | The Johns Hopkins University | Adhesive/adsorption switch on nanoparticles to increase tumor uptake and delay tumor clearance |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| US20250206704A1 (en) * | 2022-03-24 | 2025-06-26 | The Brigham And Women's Hospital, Inc. | Engineered ionophores for transport of metal ions |
| FR3156312A1 (fr) * | 2023-12-08 | 2025-06-13 | Aken Medical | Nanoparticules radioactives de type cœur/enveloppes utiles en radiothérapie ciblée |
| FR3156311A1 (fr) * | 2023-12-08 | 2025-06-13 | Aken Medical | Nanoparticules radioactives de type cœur/enveloppe utiles en radiothérapie ciblée |
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| US4310506A (en) * | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
| US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4753788A (en) * | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
| US5622713A (en) | 1985-09-17 | 1997-04-22 | The Regents Of The University Of California | Method of detoxifying animal suffering from overdose |
| ATE88642T1 (de) | 1987-11-04 | 1993-05-15 | Vestar Inc | Zusammensetzung und verfahren zur anwendung von in liposomen eingeschlossenen verbindungen in der neutroneneinfangtherapie von tumoren. |
| US5258499A (en) | 1988-05-16 | 1993-11-02 | Vestar, Inc. | Liposome targeting using receptor specific ligands |
| US5688488A (en) | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5525232A (en) | 1990-03-02 | 1996-06-11 | The Liposome Company, Inc. | Method for entrapment of cationic species in lemellar vesicles |
| JPH075561B2 (ja) | 1991-12-17 | 1995-01-25 | 工業技術院長 | α−アミノ酸のジアミド誘導体 |
| CA2093381A1 (en) * | 1992-04-07 | 1993-10-08 | Hideyuki Sawahara | Liposome formulation and process for production thereof |
| US5837282A (en) * | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
| US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
| US5945502A (en) | 1997-11-13 | 1999-08-31 | Xerox Corporation | Electroluminescent polymer compositions and processes thereof |
| NO312708B1 (no) | 2000-02-21 | 2002-06-24 | Anticancer Therapeutic Inv Sa | Radioaktive liposomer til terapi |
| CA2455598A1 (en) * | 2001-07-27 | 2003-02-13 | Targesome, Inc. | Lipid constructs as therapeutic and imaging agents |
| ES2290333T3 (es) | 2001-11-13 | 2008-02-16 | Celator Pharmaceuticals, Inc. | Composiciones de vehiculos lipidicos y metodos para la retencion mejorada de farmacos. |
| JP4360917B2 (ja) | 2002-02-26 | 2009-11-11 | 株式会社バイオメッドコア | リポソームへの金属錯体の封入方法 |
| WO2004082626A2 (en) | 2003-03-18 | 2004-09-30 | Ethicon, Inc. | Aromatase inhibitor diagnosis and therapy |
| EP1616182A4 (en) | 2003-03-18 | 2008-04-16 | Ethicon Inc | REPLACEMENT ENZYMOTHERAPY WITH 17-BETA-HYDROXYSTEROID DESHYDROGENASE TYPE 2 |
| JP2006045132A (ja) | 2004-08-05 | 2006-02-16 | Konica Minolta Medical & Graphic Inc | リポソーム含有磁気共鳴造影剤 |
| US20060040980A1 (en) | 2004-08-20 | 2006-02-23 | Lind Stuart E | Ionophores as cancer chemotherapeutic agents |
| GB0423565D0 (en) | 2004-10-22 | 2004-11-24 | Algeta As | Formulation |
| ITMI20050328A1 (it) | 2005-03-03 | 2006-09-04 | Univ Degli Studi Milano | Composti peptidomimetrici e preparazione di derivati biologicamente attivi |
| TW200922630A (en) | 2007-09-26 | 2009-06-01 | Nat Health Research Institutes | Liposome compositions useful for tumor imaging and treatment |
| WO2009140215A2 (en) | 2008-05-11 | 2009-11-19 | Geraghty, Erin | Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds |
| JP5429710B2 (ja) * | 2009-03-30 | 2014-02-26 | 独立行政法人放射線医学総合研究所 | 治療薬剤の標的部位への集積及び放出を追跡可能な治療薬剤含有リポソームおよびその製造方法 |
| CA2768444A1 (en) | 2009-07-17 | 2011-01-20 | Rigshospitalet | Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines |
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2011
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- 2011-12-14 JP JP2013543530A patent/JP5947807B2/ja not_active Expired - Fee Related
- 2011-12-14 WO PCT/DK2011/050479 patent/WO2012079582A1/en not_active Ceased
- 2011-12-14 BR BR112013014735A patent/BR112013014735A2/pt not_active IP Right Cessation
- 2011-12-14 RU RU2013132610/15A patent/RU2013132610A/ru not_active Application Discontinuation
- 2011-12-14 AU AU2011344865A patent/AU2011344865B2/en not_active Ceased
- 2011-12-14 DK DK11804942.8T patent/DK2651447T3/en active
- 2011-12-14 US US13/992,080 patent/US9226984B2/en not_active Expired - Fee Related
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- 2011-12-14 EP EP11804942.8A patent/EP2651447B1/en not_active Not-in-force
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2015
- 2015-12-14 US US14/968,019 patent/US20160158392A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024258223A1 (ko) * | 2023-06-14 | 2024-12-19 | 주식회사 지티아이바이오사이언스 | 방사성 동위원소를 포함하는 나노입자 조성물을 제조하는 장치 및 이의 제조 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011344865B2 (en) | 2017-03-09 |
| WO2012079582A1 (en) | 2012-06-21 |
| RU2013132610A (ru) | 2015-01-20 |
| US20130251630A1 (en) | 2013-09-26 |
| US9226984B2 (en) | 2016-01-05 |
| AU2011344865A1 (en) | 2013-07-11 |
| US20160158392A1 (en) | 2016-06-09 |
| EP2651447B1 (en) | 2018-08-29 |
| DK2651447T3 (en) | 2018-12-17 |
| BR112013014735A2 (pt) | 2016-10-04 |
| EP2651447A1 (en) | 2013-10-23 |
| JP5947807B2 (ja) | 2016-07-06 |
| JP2014506240A (ja) | 2014-03-13 |
| CA2821024A1 (en) | 2012-06-21 |
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