AU2011316689B2 - Cyclosporin analogs - Google Patents

Cyclosporin analogs

Info

Publication number
AU2011316689B2
AU2011316689B2 AU2011316689A AU2011316689A AU2011316689B2 AU 2011316689 B2 AU2011316689 B2 AU 2011316689B2 AU 2011316689 A AU2011316689 A AU 2011316689A AU 2011316689 A AU2011316689 A AU 2011316689A AU 2011316689 B2 AU2011316689 B2 AU 2011316689B2
Authority
AU
Australia
Prior art keywords
compound according
isobutyl
chch
cyclosporin
ocular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011316689A
Other languages
English (en)
Other versions
AU2011316689A1 (en
Inventor
William Robert Carling
Michael E. Garst
Christopher S. Schaumburg
David Arthur Scowen
Michael E. Stern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AU2011316689A1 publication Critical patent/AU2011316689A1/en
Application granted granted Critical
Publication of AU2011316689B2 publication Critical patent/AU2011316689B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2011316689A 2010-10-12 2011-10-11 Cyclosporin analogs Ceased AU2011316689B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39245110P 2010-10-12 2010-10-12
US61/392,451 2010-10-12
PCT/US2011/055788 WO2012051193A1 (en) 2010-10-12 2011-10-11 Cyclosporin analogs

Publications (2)

Publication Number Publication Date
AU2011316689A1 AU2011316689A1 (en) 2013-05-02
AU2011316689B2 true AU2011316689B2 (en) 2016-07-14

Family

ID=44883796

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011316689A Ceased AU2011316689B2 (en) 2010-10-12 2011-10-11 Cyclosporin analogs

Country Status (12)

Country Link
US (2) US9175042B2 (cg-RX-API-DMAC7.html)
EP (1) EP2627663B1 (cg-RX-API-DMAC7.html)
JP (1) JP5805773B2 (cg-RX-API-DMAC7.html)
KR (1) KR20140026328A (cg-RX-API-DMAC7.html)
CN (1) CN103261212A (cg-RX-API-DMAC7.html)
AU (1) AU2011316689B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013008749A2 (cg-RX-API-DMAC7.html)
CA (1) CA2814191A1 (cg-RX-API-DMAC7.html)
IL (1) IL225616A0 (cg-RX-API-DMAC7.html)
MX (1) MX2013004062A (cg-RX-API-DMAC7.html)
RU (1) RU2013120927A (cg-RX-API-DMAC7.html)
WO (1) WO2012051193A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100305047A1 (en) * 2009-05-27 2010-12-02 Allergan, Inc. Cyclosporin derivatives for enhancing the growth of hair
AU2011342284C1 (en) * 2010-12-15 2017-07-13 Contravir Pharmaceuticals, Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3
CN104487449A (zh) * 2012-06-01 2015-04-01 阿勒根公司 环孢菌素a类似物
WO2014138437A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Steroid conjugates
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
US20180193003A1 (en) 2016-12-07 2018-07-12 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
US11523772B2 (en) 2016-12-14 2022-12-13 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
CN115028681B (zh) * 2022-08-11 2022-11-15 中国科学院微生物研究所 一种降解亲环素a的嵌合体化合物及其制备方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649047A (en) 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2762843B1 (fr) 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2772768B1 (fr) * 1997-12-19 2000-01-14 Rhone Poulenc Rorer Sa Nouveau procede de preparation de derives de cyclosporine
HUP0102833A3 (en) 1998-06-12 2002-03-28 Chem Ag C Cyclosporins, process for preparation thereof and their use
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
CN100478025C (zh) * 2005-03-25 2009-04-15 中国科学院上海药物研究所 一种环孢菌素a眼用微乳制剂及其制备方法
DK2023918T3 (da) * 2006-05-19 2011-04-26 Scynexis Inc Cyclosporiner til behandlingen og forebyggelse af okulære lidelser
CN101687013A (zh) * 2007-05-04 2010-03-31 阿勒根公司 环孢菌素在治疗具有人工晶状体的患者中的用途
BRPI0915552A2 (pt) 2008-07-10 2017-06-20 Allergan Inc derivados de ciclosporina, seu uso e sua composição farmacêutica
CN107007815A (zh) 2010-07-16 2017-08-04 美国科技环球有限公司 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用
US9573978B2 (en) * 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
WO2012051194A1 (en) 2010-10-12 2012-04-19 Allergan, Inc. Cyclosporin analogs
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
ES2625502T3 (es) * 2010-12-03 2017-07-19 S&T Global Inc Nuevos derivados de ciclosporina para el tratamiento y prevención de una infección vírica

Also Published As

Publication number Publication date
JP5805773B2 (ja) 2015-11-10
RU2013120927A (ru) 2014-11-20
EP2627663B1 (en) 2018-02-21
IL225616A0 (en) 2013-06-27
US9175042B2 (en) 2015-11-03
BR112013008749A2 (pt) 2019-09-24
JP2013544786A (ja) 2013-12-19
MX2013004062A (es) 2013-07-22
US20160022765A1 (en) 2016-01-28
US20120135939A1 (en) 2012-05-31
EP2627663A1 (en) 2013-08-21
WO2012051193A1 (en) 2012-04-19
KR20140026328A (ko) 2014-03-05
CA2814191A1 (en) 2012-04-19
AU2011316689A1 (en) 2013-05-02
CN103261212A (zh) 2013-08-21
US9561259B2 (en) 2017-02-07

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired