AU2011263478B2 - Injectable flowable composition comprising buprenorphine - Google Patents

Injectable flowable composition comprising buprenorphine Download PDF

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Publication number
AU2011263478B2
AU2011263478B2 AU2011263478A AU2011263478A AU2011263478B2 AU 2011263478 B2 AU2011263478 B2 AU 2011263478B2 AU 2011263478 A AU2011263478 A AU 2011263478A AU 2011263478 A AU2011263478 A AU 2011263478A AU 2011263478 B2 AU2011263478 B2 AU 2011263478B2
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AU
Australia
Prior art keywords
buprenorphine
flowable composition
implant
metabolite
prodrug
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Active
Application number
AU2011263478A
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English (en)
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AU2011263478A1 (en
Inventor
Richard L. Norton
Andrew Watkins
Mingxing Zhou
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Indivior UK Ltd
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Indivior UK Ltd
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Application filed by Indivior UK Ltd filed Critical Indivior UK Ltd
Publication of AU2011263478A1 publication Critical patent/AU2011263478A1/en
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Publication of AU2011263478B2 publication Critical patent/AU2011263478B2/en
Assigned to INDIVIOR UK LIMITED reassignment INDIVIOR UK LIMITED Request to Amend Deed and Register Assignors: RB PHARMACEUTICALS LIMITED
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2011263478A 2010-06-08 2011-06-06 Injectable flowable composition comprising buprenorphine Active AU2011263478B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1009549.5A GB2481018B (en) 2010-06-08 2010-06-08 Injectable flowable composition comprising buprenorphine
GB1009549.5 2010-06-08
PCT/GB2011/051057 WO2011154724A2 (en) 2010-06-08 2011-06-06 Compositions

Publications (2)

Publication Number Publication Date
AU2011263478A1 AU2011263478A1 (en) 2013-01-10
AU2011263478B2 true AU2011263478B2 (en) 2015-01-22

Family

ID=42471306

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011263478A Active AU2011263478B2 (en) 2010-06-08 2011-06-06 Injectable flowable composition comprising buprenorphine

Country Status (32)

Country Link
US (1) US8921387B2 (https=)
EP (3) EP3360538B1 (https=)
JP (2) JP5986072B2 (https=)
KR (1) KR101865689B1 (https=)
CN (1) CN103079544B (https=)
AU (1) AU2011263478B2 (https=)
BR (1) BR112012031290A2 (https=)
CA (1) CA2801676C (https=)
CL (1) CL2012003462A1 (https=)
CO (1) CO6670529A2 (https=)
CY (1) CY1120761T1 (https=)
DK (2) DK3360538T3 (https=)
ES (2) ES2939612T3 (https=)
FI (1) FI3360538T3 (https=)
GB (2) GB2513267B (https=)
HR (1) HRP20180118T1 (https=)
HU (1) HUE038275T2 (https=)
IL (2) IL223488A (https=)
LT (1) LT2579874T (https=)
MX (1) MX339209B (https=)
MY (1) MY171625A (https=)
NO (1) NO2579874T3 (https=)
NZ (1) NZ604026A (https=)
PL (1) PL2579874T3 (https=)
PT (1) PT2579874T (https=)
RS (1) RS56820B1 (https=)
RU (1) RU2607498C2 (https=)
SG (1) SG186200A1 (https=)
SI (1) SI2579874T1 (https=)
SM (1) SMT201800038T1 (https=)
WO (1) WO2011154724A2 (https=)
ZA (1) ZA201209233B (https=)

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US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2513060B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
GB2513267B (en) 2010-06-08 2015-03-18 Rb Pharmaceuticals Ltd Injectable flowable composition comprising buprenorphine
WO2013126552A1 (en) 2012-02-21 2013-08-29 Auburn University Buprenorphine nanoparticle composition and methods thereof
KR102082529B1 (ko) 2012-04-17 2020-02-27 퍼듀 퍼머 엘피 오피오이드-유도 유해 약역학 반응을 치료하기 위한 시스템 및 방법
HRP20210068T1 (hr) * 2012-07-26 2021-03-05 Camurus Ab Opioidne formulacije
WO2014016428A1 (en) * 2012-07-26 2014-01-30 Camurus Ab Opioid formulations
WO2014093907A1 (en) * 2012-12-13 2014-06-19 A.P. Pharma, Inc. Pharmaceutical composition comprising antiemetic compounds and polyorthoester
US9393211B2 (en) 2013-03-15 2016-07-19 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
US9636308B2 (en) 2013-03-15 2017-05-02 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
US9592227B2 (en) * 2013-03-15 2017-03-14 Heron Therapeutics, Inc. Compositions of a polyorthoester and an aprotic solvent
GB201404139D0 (en) * 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
WO2018048460A1 (en) 2014-04-21 2018-03-15 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
DK3134070T3 (da) * 2014-04-21 2020-12-21 Heron Therapeutics Inc Sammensætninger af en polyorthoester og en organisk syre-excipiens
PT3134068T (pt) 2014-04-21 2021-10-18 Heron Therapeutics Inc Sistemas de libertação poliméricos de longa duração
PL3137081T3 (pl) 2014-04-28 2018-06-29 Orphomed, Inc. Dimer buprenorfiny i jego zastosowanie w leczeniu chorób układu pokarmowego
GB201419091D0 (en) * 2014-10-27 2014-12-10 Camurus Ab Formulations
CA3015557C (en) 2014-11-07 2019-07-16 Indivior Uk Limited The use of sustained-release buprenorphine formulations for the treatment of pain or opioid use disorders
JP6949820B2 (ja) * 2015-08-03 2021-10-13 トルマー インターナショナル リミテッド 薬物の持続投与のための液体ポリマー送達システム
US20200155449A1 (en) 2015-11-16 2020-05-21 Medincell Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
SG11201901294QA (en) 2016-09-13 2019-03-28 Alar Pharmaceuticals Inc Sustained-release buprenorphine formulations background of invention
AU2018283724B2 (en) 2017-06-16 2021-08-19 Indivior Uk Limited Methods to treat opioid use disorder
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
WO2019144079A1 (en) 2018-01-22 2019-07-25 Yuhua Li Pharmaceutical composition for sustained release delivery of buprenorphine
AR117426A1 (es) * 2018-05-11 2021-08-04 Alar Pharmaceuticals Inc Formulaciones inyectables de acción prolongada y formas cristalinas de derivados de buprenorfina
IL282120B2 (en) 2018-10-11 2025-08-01 Indivior Uk Ltd Buprenorphine to treat respiratory depression
US12403291B2 (en) 2019-08-30 2025-09-02 Intersect Ent, Inc. Submucosal bioresorbable drug eluting platform
CN118831057A (zh) * 2023-04-25 2024-10-25 深圳善康医药科技股份有限公司 丁丙诺啡植入剂及其制备方法

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Also Published As

Publication number Publication date
GB2481018A (en) 2011-12-14
SMT201800038T1 (it) 2018-03-08
KR101865689B1 (ko) 2018-06-08
SG186200A1 (en) 2013-01-30
HRP20180118T1 (hr) 2018-03-09
AU2011263478A1 (en) 2013-01-10
LT2579874T (lt) 2018-02-12
MY171625A (en) 2019-10-21
WO2011154724A3 (en) 2012-07-12
KR20130135026A (ko) 2013-12-10
GB201413064D0 (en) 2014-09-03
RS56820B1 (sr) 2018-04-30
PL2579874T3 (pl) 2018-05-30
CY1120761T1 (el) 2019-12-11
EP4218720A1 (en) 2023-08-02
CN103079544A (zh) 2013-05-01
GB2513267A (en) 2014-10-22
ZA201209233B (en) 2014-04-30
GB2513267B (en) 2015-03-18
EP2579874B1 (en) 2018-01-10
ES2939612T3 (es) 2023-04-25
GB201009549D0 (en) 2010-07-21
CO6670529A2 (es) 2013-05-15
DK2579874T3 (da) 2018-01-29
DK3360538T3 (da) 2023-03-06
US20130210853A1 (en) 2013-08-15
IL223488A (en) 2017-10-31
CN103079544B (zh) 2017-06-09
CA2801676C (en) 2018-08-07
EP3360538B1 (en) 2023-02-15
ES2656938T3 (es) 2018-03-01
WO2011154724A9 (en) 2012-08-16
JP6251774B2 (ja) 2017-12-20
HUE038275T2 (hu) 2018-10-29
JP2016155865A (ja) 2016-09-01
IL254417A0 (en) 2017-11-30
MX2012014335A (es) 2013-03-05
EP2579874A2 (en) 2013-04-17
NZ604026A (en) 2015-01-30
JP5986072B2 (ja) 2016-09-06
CA2801676A1 (en) 2011-12-15
MX339209B (es) 2016-04-15
NO2579874T3 (https=) 2018-06-09
GB2481018B (en) 2015-03-18
RU2607498C2 (ru) 2017-01-10
CL2012003462A1 (es) 2013-04-01
US8921387B2 (en) 2014-12-30
JP2013533230A (ja) 2013-08-22
PT2579874T (pt) 2018-01-29
BR112012031290A2 (pt) 2016-11-01
FI3360538T3 (fi) 2023-03-22
SI2579874T1 (en) 2018-03-30
WO2011154724A2 (en) 2011-12-15
EP3360538A1 (en) 2018-08-15
RU2012157244A (ru) 2014-07-20

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