AU2011223456A1 - Oligomer-specific amyloid beta epitope and antibodies - Google Patents
Oligomer-specific amyloid beta epitope and antibodies Download PDFInfo
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- AU2011223456A1 AU2011223456A1 AU2011223456A AU2011223456A AU2011223456A1 AU 2011223456 A1 AU2011223456 A1 AU 2011223456A1 AU 2011223456 A AU2011223456 A AU 2011223456A AU 2011223456 A AU2011223456 A AU 2011223456A AU 2011223456 A1 AU2011223456 A1 AU 2011223456A1
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Genetics & Genomics (AREA)
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- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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| AU2016208334A AU2016208334A1 (en) | 2010-03-03 | 2016-07-27 | Oligomer-specific amyloid beta epitope and antibodies |
Applications Claiming Priority (3)
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| US31016710P | 2010-03-03 | 2010-03-03 | |
| US61/310,167 | 2010-03-03 | ||
| PCT/CA2011/000238 WO2011106885A1 (en) | 2010-03-03 | 2011-03-03 | Oligomer-specific amyloid beta epitope and antibodies |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| AU2013205000A Division AU2013205000B2 (en) | 2010-03-03 | 2013-04-13 | Oligomer-specific amyloid beta epitope and antibodies |
| AU2016208334A Division AU2016208334A1 (en) | 2010-03-03 | 2016-07-27 | Oligomer-specific amyloid beta epitope and antibodies |
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| WO2011106885A1 (en) | 2010-03-03 | 2011-09-09 | The University Of British Columbia | Oligomer-specific amyloid beta epitope and antibodies |
| TWI571207B (zh) | 2011-06-26 | 2017-02-21 | 安麗托克斯公司 | 用於條件化動物飼料之寒冷天氣調配物 |
| EP2780082A4 (en) * | 2011-11-10 | 2015-08-05 | Cangene U S Inc | COMPOSITION AND METHOD FOR THE TREATMENT OF MORBUS ALZHEIMER |
| CN104380111B (zh) * | 2012-04-05 | 2017-08-29 | 于利希研究中心有限公司 | 包含多价结合淀粉样β蛋白的D‑肽的聚合物及其应用 |
| CA2938129A1 (en) * | 2014-02-03 | 2015-08-06 | Cangene Corporation | Humanized beta-amyloid binding molecules and uses thereof |
| WO2016008047A1 (en) * | 2014-07-14 | 2016-01-21 | Cangene Corporation | Cyclic peptide vaccination for treatment of amyloid beta-related disorders |
| WO2017079835A1 (en) * | 2015-11-09 | 2017-05-18 | The University Of British Columbia | Amyloid beta epitopes and antibodies thereto |
| EP3374906B1 (en) | 2015-11-09 | 2022-01-05 | The University Of British Columbia | Systems and methods for predicting misfolded protein epitopes by collective coordinate biasing |
| EP3374382A4 (en) * | 2015-11-09 | 2019-05-15 | The University Of British Columbia | EPITOPES IN AMYLOID BETA AND CONFORMATION-SELECTIVE ANTIBODIES |
| EP3374381A4 (en) * | 2015-11-09 | 2019-05-15 | The University Of British Columbia | EPITOPES IN THE AMYLOID-BETA MEDIUM REGION AND CONFORMITY-SELECTIVE ANTIBODIES THEREOF |
| EP3374379A4 (en) * | 2015-11-09 | 2019-05-15 | The University Of British Columbia | N-TERMINAL EPITOPES IN AMYLOID BETA AND CONFORMATION-SELECTIVE ANTIBODIES |
| CN109476729A (zh) | 2016-07-18 | 2019-03-15 | 英属哥伦比亚大学 | 淀粉样蛋白β的抗体 |
| US20180125920A1 (en) * | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
| WO2019023247A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND |
| WO2020033756A1 (en) * | 2018-08-09 | 2020-02-13 | F. Hoffmann-La Roche Ag | Determination of parkinson's disease |
| AU2019356804B2 (en) * | 2018-10-07 | 2025-05-29 | Promis Neurosciences, Inc. | Conformation-specific epitopes in alpha-synuclein, antibodies thereto and methods related thereof |
| EP3918323A4 (en) | 2019-01-30 | 2022-12-28 | TrueBinding, Inc. | ANTI-GAL3 ANTIBODIES AND USES THEREOF |
| US12352719B2 (en) | 2019-09-20 | 2025-07-08 | KYCERA AVX Components Corporation | Somatic cell-based electrical biosensor |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
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| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| IL162181A (en) * | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
| US6127977A (en) | 1996-11-08 | 2000-10-03 | Cohen; Nathan | Microstrip patch antenna with fractal structure |
| DE69736976T2 (de) | 1996-03-29 | 2007-10-18 | Trustees Of Boston University, Boston | Mit Alzheimer Krankheit verknüpften Verfahren zur Diagnose, zur Herstellung von Medikamenten und zum Screenen von Substanzen sowie aus Beta-Amyloid abgeleiteten Peptiden |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6750324B1 (en) * | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
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| US6686443B1 (en) | 2000-05-26 | 2004-02-03 | The Regents Of The University Of California | Chemical reagents for formation of disulfide bonds in peptides |
| DE04759123T1 (de) | 2003-04-07 | 2005-08-18 | Novetide Ltd. | Verfahren zur herstellung cyclischer peptide |
| EP1484336A1 (en) | 2003-06-02 | 2004-12-08 | Pevion Biotech Ltd. | Methods for synthesizing conformationally constrained peptides, peptidometics and the use thereof as synthetic vaccines |
| US20080044356A1 (en) * | 2004-10-22 | 2008-02-21 | Regents Of The University Of Minnesota | Assemblies of Oligomeric Amyloid Beta Protein and Uses Thereof |
| IL169622A0 (en) * | 2005-07-11 | 2007-07-04 | Yeda Res & Dev | Methods of screening modulators of interleukin-32 (il-32)modulators of il-32 identified by said methods and their use |
| AU2006270245A1 (en) * | 2005-07-13 | 2007-01-25 | Coimmune Inc. | Catalytic immunoglobulins |
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| EA020324B1 (ru) | 2006-07-18 | 2014-10-30 | Санофи-Авентис | АНТИТЕЛА К РЕЦЕПТОРУ ЭФРИНА EphA2 И ИХ ПРИМЕНЕНИЕ |
| RU2546234C2 (ru) | 2008-07-01 | 2015-04-10 | Де Стат Дер Недерланден, Верт.Дор Де Министер Ван Ввс | Вакцина против интермедиата с амилоидным сворачиванием |
| CN102203124A (zh) * | 2008-07-25 | 2011-09-28 | 雅培制药有限公司 | 淀粉状蛋白β肽类似物，其寡聚物，用于制备的方法以及包括所述类似物或寡聚物的组合物，及其用途 |
| WO2010010469A2 (en) | 2008-07-25 | 2010-01-28 | Abbott Gmbh & Co. Kg | Abeta (x-38..43) oligomers, and processes, compositions, and uses thereof |
| US8410243B2 (en) | 2008-12-17 | 2013-04-02 | The Governors Of The University Of Alberta | Aromatic ether-containing fluorene monomers, processes for their preparation and polymerization thereof |
| WO2010075280A2 (en) | 2008-12-22 | 2010-07-01 | Sloan-Kettering Institute For Cancer Research | Coumarin-based compounds |
| KR20130043088A (ko) | 2010-02-09 | 2013-04-29 | 브리스톨-마이어스 스큅 컴퍼니 | 면역검정 표준물 및 검정내 보정 표준물을 사용한 임상 바이오마커의 측정 |
| WO2011106885A1 (en) | 2010-03-03 | 2011-09-09 | The University Of British Columbia | Oligomer-specific amyloid beta epitope and antibodies |
| US9320793B2 (en) | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| EP2780082A4 (en) | 2011-11-10 | 2015-08-05 | Cangene U S Inc | COMPOSITION AND METHOD FOR THE TREATMENT OF MORBUS ALZHEIMER |
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| NZ602548A (en) | 2014-12-24 |
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| SG183854A1 (en) | 2012-10-30 |
| KR101831459B1 (ko) | 2018-04-04 |
| EP3056510B1 (en) | 2018-10-03 |
| CN102858796A (zh) | 2013-01-02 |
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