CA2791538C - Oligomer-specific amyloid beta epitope and antibodies - Google Patents
Oligomer-specific amyloid beta epitope and antibodies Download PDFInfo
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- CA2791538C CA2791538C CA2791538A CA2791538A CA2791538C CA 2791538 C CA2791538 C CA 2791538C CA 2791538 A CA2791538 A CA 2791538A CA 2791538 A CA2791538 A CA 2791538A CA 2791538 C CA2791538 C CA 2791538C
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
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- Genetics & Genomics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31016710P | 2010-03-03 | 2010-03-03 | |
| US61/310,167 | 2010-03-03 | ||
| PCT/CA2011/000238 WO2011106885A1 (en) | 2010-03-03 | 2011-03-03 | Oligomer-specific amyloid beta epitope and antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2791538A1 CA2791538A1 (en) | 2011-09-09 |
| CA2791538C true CA2791538C (en) | 2019-04-16 |
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| CA2791538A Expired - Fee Related CA2791538C (en) | 2010-03-03 | 2011-03-03 | Oligomer-specific amyloid beta epitope and antibodies |
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| CL (1) | CL2012002438A1 (enExample) |
| CO (1) | CO6640211A2 (enExample) |
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| WO (1) | WO2011106885A1 (enExample) |
| ZA (1) | ZA201206916B (enExample) |
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| RU2644335C2 (ru) | 2010-03-03 | 2018-02-08 | Зе Юниверсити Оф Бритиш Коламбия | Эпитоп, специфичный к олигомеру амилоида бета, и антитела |
| TWI571207B (zh) | 2011-06-26 | 2017-02-21 | 安麗托克斯公司 | 用於條件化動物飼料之寒冷天氣調配物 |
| CA2855669A1 (en) * | 2011-11-10 | 2013-05-16 | Cangene U.S., Incorporated | Compositions and methods for treating alzheimer's disease |
| CN104380111B (zh) * | 2012-04-05 | 2017-08-29 | 于利希研究中心有限公司 | 包含多价结合淀粉样β蛋白的D‑肽的聚合物及其应用 |
| WO2015113169A1 (en) * | 2014-02-03 | 2015-08-06 | Cnj Holdings, Inc. | Humanized beta-amyloid binding molecules and uses thereof |
| WO2016008047A1 (en) * | 2014-07-14 | 2016-01-21 | Cangene Corporation | Cyclic peptide vaccination for treatment of amyloid beta-related disorders |
| CA3004593A1 (en) | 2015-11-09 | 2017-05-18 | The University Of British Columbia | Systems and methods for predicting misfolded protein epitopes by collective coordinate biasing |
| CN108350051A (zh) * | 2015-11-09 | 2018-07-31 | 英属哥伦比亚大学 | 淀粉样蛋白β中的N-末端表位及其构象选择性抗体 |
| US20180326027A1 (en) * | 2015-11-09 | 2018-11-15 | The University Of British Columbia | Epitopes in amyloid beta and conformationally-selective antibodies thereto |
| CA3004498A1 (en) * | 2015-11-09 | 2017-05-18 | Neil R. Cashman | Amyloid beta epitopes and antibodies thereto |
| AU2016354688B2 (en) | 2015-11-09 | 2021-12-16 | The University Of British Columbia | Epitopes in Amyloid beta mid-region and conformationally-selective antibodies thereto |
| EP3484919A4 (en) | 2016-07-18 | 2020-03-04 | The University of British Columbia | ANTI-BETA-AMYLOID ANTIBODIES |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| WO2020033756A1 (en) * | 2018-08-09 | 2020-02-13 | F. Hoffmann-La Roche Ag | Determination of parkinson's disease |
| AU2019356804B2 (en) * | 2018-10-07 | 2025-05-29 | Promis Neurosciences, Inc. | Conformation-specific epitopes in alpha-synuclein, antibodies thereto and methods related thereof |
| US12352719B2 (en) | 2019-09-20 | 2025-07-08 | KYCERA AVX Components Corporation | Somatic cell-based electrical biosensor |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
| US6127977A (en) | 1996-11-08 | 2000-10-03 | Cohen; Nathan | Microstrip patch antenna with fractal structure |
| CA2250075C (en) | 1996-03-29 | 2008-06-10 | The Trustees Of Boston University | Methods for diagnosing and treating alzheimer's disease |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6750324B1 (en) * | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US7252952B2 (en) | 2000-03-06 | 2007-08-07 | Rigel Pharmaceuticals, Inc. | In vivo production of cyclic peptides for inhibiting protein—protein interaction |
| US6686443B1 (en) | 2000-05-26 | 2004-02-03 | The Regents Of The University Of California | Chemical reagents for formation of disulfide bonds in peptides |
| WO2004092202A1 (en) | 2003-04-07 | 2004-10-28 | Novetide, Ltd. | Process for production of cyclic peptides |
| EP1484336A1 (en) | 2003-06-02 | 2004-12-08 | Pevion Biotech Ltd. | Methods for synthesizing conformationally constrained peptides, peptidometics and the use thereof as synthetic vaccines |
| US20080044356A1 (en) * | 2004-10-22 | 2008-02-21 | Regents Of The University Of Minnesota | Assemblies of Oligomeric Amyloid Beta Protein and Uses Thereof |
| IL169622A0 (en) | 2005-07-11 | 2007-07-04 | Yeda Res & Dev | Methods of screening modulators of interleukin-32 (il-32)modulators of il-32 identified by said methods and their use |
| US20090297534A1 (en) * | 2005-07-13 | 2009-12-03 | Sudhir Paul | Catalytic Immunoglobulins BBK32 and Uses Therefor |
| WO2007103739A2 (en) | 2006-03-01 | 2007-09-13 | The University Of Utah Research Foundation | Methods and compositions related to cyclic peptide synthesis |
| CN101622276B (zh) | 2006-07-18 | 2015-04-22 | 赛诺菲-安万特 | 用于治疗癌症的抗epha2的拮抗抗体 |
| ES2397641T3 (es) * | 2008-07-01 | 2013-03-08 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Vacuna contra el intermediario de plegado amiloide |
| US20110092445A1 (en) * | 2008-07-25 | 2011-04-21 | Abbott Laboratories | Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses |
| US20100173828A1 (en) | 2008-07-25 | 2010-07-08 | Abbott Gmbh & Co. Kg | Aß(X - 38 .. 43) oligomers, and processes, compositions, and uses thereof |
| US8410243B2 (en) | 2008-12-17 | 2013-04-02 | The Governors Of The University Of Alberta | Aromatic ether-containing fluorene monomers, processes for their preparation and polymerization thereof |
| AU2009330124A1 (en) | 2008-12-22 | 2011-07-14 | Sloan-Kettering Institute For Cancer Research | Coumarin-based compounds for the treatment of Alzheimer's disease and cancer |
| EP2534490B1 (en) | 2010-02-09 | 2015-12-16 | Bristol-Myers Squibb Company | Immunoassay standards and measurement of clinical biomarkers using intra-assay calibration standards |
| RU2644335C2 (ru) | 2010-03-03 | 2018-02-08 | Зе Юниверсити Оф Бритиш Коламбия | Эпитоп, специфичный к олигомеру амилоида бета, и антитела |
| US9320793B2 (en) | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| CA2855669A1 (en) | 2011-11-10 | 2013-05-16 | Cangene U.S., Incorporated | Compositions and methods for treating alzheimer's disease |
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2011
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- 2011-03-03 SG SG2012064770A patent/SG183854A1/en unknown
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- 2011-03-03 EP EP15203261.1A patent/EP3056510B1/en active Active
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2012
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2015
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Also Published As
| Publication number | Publication date |
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| RU2644335C2 (ru) | 2018-02-08 |
| MX2012010175A (es) | 2012-11-23 |
| JP6190113B2 (ja) | 2017-08-30 |
| WO2011106885A1 (en) | 2011-09-09 |
| US20130084283A1 (en) | 2013-04-04 |
| RU2012139043A (ru) | 2014-04-10 |
| CA2791538A1 (en) | 2011-09-09 |
| IL221695B (en) | 2019-01-31 |
| EP2542571A4 (en) | 2013-07-31 |
| CN102858796A (zh) | 2013-01-02 |
| EP3056510A1 (en) | 2016-08-17 |
| US9849165B2 (en) | 2017-12-26 |
| SG183854A1 (en) | 2012-10-30 |
| BR112012022229A2 (pt) | 2016-07-05 |
| CN102858796B (zh) | 2016-05-11 |
| CO6640211A2 (es) | 2013-03-22 |
| ZA201206916B (en) | 2014-03-26 |
| EP2542571B1 (en) | 2016-05-25 |
| AU2011223456A1 (en) | 2012-10-18 |
| JP6494565B2 (ja) | 2019-04-03 |
| EP2542571A1 (en) | 2013-01-09 |
| MX341536B (es) | 2016-08-24 |
| NZ602548A (en) | 2014-12-24 |
| US20160228522A1 (en) | 2016-08-11 |
| KR101831459B1 (ko) | 2018-04-04 |
| JP2013524774A (ja) | 2013-06-20 |
| JP2016193914A (ja) | 2016-11-17 |
| US9216217B2 (en) | 2015-12-22 |
| EP3056510B1 (en) | 2018-10-03 |
| KR20130045850A (ko) | 2013-05-06 |
| US20140314773A1 (en) | 2014-10-23 |
| CL2012002438A1 (es) | 2013-09-13 |
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| MKLA | Lapsed |
Effective date: 20200303 |