AU2011218490B9 - Solid forms comprising a cyclopropyl amide derivative - Google Patents
Solid forms comprising a cyclopropyl amide derivative Download PDFInfo
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- AU2011218490B9 AU2011218490B9 AU2011218490A AU2011218490A AU2011218490B9 AU 2011218490 B9 AU2011218490 B9 AU 2011218490B9 AU 2011218490 A AU2011218490 A AU 2011218490A AU 2011218490 A AU2011218490 A AU 2011218490A AU 2011218490 B9 AU2011218490 B9 AU 2011218490B9
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- solid form
- disorder
- compound
- pain
- schizophrenia
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- 239000007787 solid Substances 0.000 title claims description 104
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical class NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 title description 2
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- 238000000034 method Methods 0.000 claims description 64
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 49
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- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 7
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Classifications
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
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- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30558110P | 2010-02-18 | 2010-02-18 | |
| US61/305,581 | 2010-02-18 | ||
| PCT/SE2011/050170 WO2011102793A1 (en) | 2010-02-18 | 2011-02-17 | Solid forms comprising a cyclopropyl amide derivative |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2011218490A1 AU2011218490A1 (en) | 2012-10-04 |
| AU2011218490B2 AU2011218490B2 (en) | 2014-11-13 |
| AU2011218490B9 true AU2011218490B9 (en) | 2014-12-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2011218490A Ceased AU2011218490B9 (en) | 2010-02-18 | 2011-02-17 | Solid forms comprising a cyclopropyl amide derivative |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110201622A1 (enExample) |
| EP (1) | EP2536701A4 (enExample) |
| JP (1) | JP5746718B2 (enExample) |
| KR (1) | KR20130034009A (enExample) |
| CN (1) | CN103140481A (enExample) |
| AR (1) | AR080203A1 (enExample) |
| AU (1) | AU2011218490B9 (enExample) |
| BR (1) | BR112012020780A2 (enExample) |
| CA (1) | CA2789884A1 (enExample) |
| CL (1) | CL2012002285A1 (enExample) |
| IL (1) | IL221430A0 (enExample) |
| MX (1) | MX2012009537A (enExample) |
| NZ (1) | NZ602108A (enExample) |
| RU (1) | RU2012136921A (enExample) |
| SG (1) | SG183231A1 (enExample) |
| TW (1) | TW201136898A (enExample) |
| WO (1) | WO2011102793A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101588466B1 (ko) | 2007-08-22 | 2016-01-25 | 아스트라제네카 아베 | 시클로프로필 아미드 유도체 |
| TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| US20110201623A1 (en) | 2010-02-18 | 2011-08-18 | Uczynski Michael A | Crystalline Form Of A Cyclopropyl Benzamide Derivative |
| CN109438423A (zh) * | 2018-09-12 | 2019-03-08 | 通化师范学院 | 一种肺癌靶向化合物azd-3759的合成工艺的新方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NL297170A (enExample) * | 1963-04-04 | 1900-01-01 | ||
| US3449427A (en) * | 1965-06-03 | 1969-06-10 | Smithkline Corp | Aminocyclopropane derivatives of 5h-dibenzo(a,d)cycloheptenes |
| US3697506A (en) * | 1970-08-07 | 1972-10-10 | Pfizer | Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor |
| US3686335A (en) * | 1970-12-21 | 1972-08-22 | Smith Kline French Lab | 5-vinyl-5h-di benzo(a,d)cycloheptenes |
| US4432987A (en) * | 1982-04-23 | 1984-02-21 | Pfizer Inc. | Crystalline benzenesulfonate salts of sultamicillin |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| CA2033390A1 (en) * | 1989-12-29 | 1991-06-30 | Susumu Nakagawa | 2-(2-cyclopropylpyrrolidin-4-ylthio) carbapenem derivatives |
| DE4131139A1 (de) * | 1991-09-19 | 1993-03-25 | Bayer Ag | Verfahren zur herstellung von 1-fluor-cyclopropan-1-carbonsaeure |
| ES2157254T3 (es) * | 1993-03-12 | 2001-08-16 | Upjohn Co | Ceftiofur (acido libre) cristalino. |
| AU4531499A (en) * | 1998-06-26 | 2000-01-17 | Chugai Seiyaku Kabushiki Kaisha | Fine powder of l-alpha-aminoadipic acid derivative, oral solid preparations containing the same, and method for treatment of bulk powders |
| US6284761B1 (en) * | 1999-01-08 | 2001-09-04 | Neurogen Corporation | 1-phenyl-4-(1-[2-aryl]cyclopropyl)methylpiperazines: dopamine receptor ligands |
| SK9742002A3 (en) * | 2000-01-07 | 2003-02-04 | Transform Pharmaceuticals Inc | High-throughput formation, identification, and analysis of diverse solid-forms |
| US6521619B2 (en) * | 2000-06-29 | 2003-02-18 | Icos Corporation | Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents |
| BR0207526A (pt) * | 2001-02-23 | 2004-03-09 | Merck & Co Inc | Composto, composição farmacêutica, e, métodos para o tratamento da dor, da enxaqueca, depressão, ansiedade, esquizofrenia, doença de parkinson ou derrame cerebral |
| JP2005508321A (ja) * | 2001-09-26 | 2005-03-31 | メルク エンド カムパニー インコーポレーテッド | 結晶形態のエルタペネムナトリウム |
| US6861432B2 (en) * | 2001-11-23 | 2005-03-01 | Schering Aktiengesellschaft | Piperazine derivatives that destabilize androgen receptors |
| US20050113309A1 (en) * | 2002-03-22 | 2005-05-26 | Aeri Kim | Crystalline forms(2s)-n-5[amino(imino)methyl]-2-thienylmethyl-1-(2r)-2[(carboxymethyl) amino]-3,3-diphenylpropanoyl-2-pyrrolidinecarboxamide nh2o |
| US20040077618A1 (en) * | 2002-10-22 | 2004-04-22 | Bennani Youssef L. | Cycloalkylamides and their therapeutic applications |
| US20040209858A1 (en) * | 2002-10-22 | 2004-10-21 | Bennani Youssef L. | Cycloalkylamides and their therapeutic applications |
| MXPA05011352A (es) * | 2003-04-23 | 2005-11-28 | Glaxo Group Ltd | Derivados de piperazina y su uso para el tratamiento de enfermedades neurologicas y psiquiatricas. |
| TWI339206B (en) * | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
| KR101336106B1 (ko) * | 2005-09-16 | 2013-12-05 | 얀센 파마슈티카 엔.브이. | 히스타민 ｈ3 수용체의 조절제로서 사이클로프로필 아민 |
| RU2008132966A (ru) * | 2006-01-13 | 2010-02-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные циклогексилпиперазинилметанона и их применение в качестве модуляторов гистамин н3 рецептора |
| US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| KR20090024811A (ko) * | 2006-06-23 | 2009-03-09 | 아보트 러보러터리즈 | 히스타민 ｈ3 수용체 조절제로서의 사이클로프로필 아민 유도체 |
| TW200828371A (en) * | 2006-09-21 | 2008-07-01 | Matsushita Electric Industrial Co Ltd | Chip-type filter |
| KR101588466B1 (ko) * | 2007-08-22 | 2016-01-25 | 아스트라제네카 아베 | 시클로프로필 아미드 유도체 |
| KR101178674B1 (ko) * | 2007-10-04 | 2012-08-30 | 에프. 호프만-라 로슈 아게 | 사이클로프로필 아릴 아마이드 유도체 및 이의 용도 |
| CL2009000004A1 (es) * | 2008-01-15 | 2010-02-19 | Lilly Co Eli | Forma cristalina de r-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida; composicion farmaceutica que comprende a dicha forma cristalina; y uso para el tratamiento de diabetes o hiperglicemia. |
| TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| US20110201623A1 (en) * | 2010-02-18 | 2011-08-18 | Uczynski Michael A | Crystalline Form Of A Cyclopropyl Benzamide Derivative |
-
2011
- 2011-02-17 MX MX2012009537A patent/MX2012009537A/es not_active Application Discontinuation
- 2011-02-17 CA CA2789884A patent/CA2789884A1/en not_active Abandoned
- 2011-02-17 NZ NZ602108A patent/NZ602108A/en not_active IP Right Cessation
- 2011-02-17 CN CN201180019676XA patent/CN103140481A/zh active Pending
- 2011-02-17 US US13/029,351 patent/US20110201622A1/en not_active Abandoned
- 2011-02-17 AU AU2011218490A patent/AU2011218490B9/en not_active Ceased
- 2011-02-17 TW TW100105298A patent/TW201136898A/zh unknown
- 2011-02-17 EP EP20110744973 patent/EP2536701A4/en not_active Withdrawn
- 2011-02-17 KR KR1020127024173A patent/KR20130034009A/ko not_active Withdrawn
- 2011-02-17 WO PCT/SE2011/050170 patent/WO2011102793A1/en not_active Ceased
- 2011-02-17 RU RU2012136921/04A patent/RU2012136921A/ru not_active Application Discontinuation
- 2011-02-17 JP JP2012553848A patent/JP5746718B2/ja not_active Expired - Fee Related
- 2011-02-17 BR BR112012020780A patent/BR112012020780A2/pt not_active IP Right Cessation
- 2011-02-17 SG SG2012058848A patent/SG183231A1/en unknown
- 2011-02-17 AR ARP110100484A patent/AR080203A1/es unknown
-
2012
- 2012-08-13 IL IL221430A patent/IL221430A0/en unknown
- 2012-08-17 CL CL2012002285A patent/CL2012002285A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2012136921A (ru) | 2014-03-27 |
| BR112012020780A2 (pt) | 2016-05-03 |
| AU2011218490A1 (en) | 2012-10-04 |
| MX2012009537A (es) | 2012-08-31 |
| CA2789884A1 (en) | 2011-08-25 |
| KR20130034009A (ko) | 2013-04-04 |
| CN103140481A (zh) | 2013-06-05 |
| NZ602108A (en) | 2014-09-26 |
| EP2536701A4 (en) | 2014-05-07 |
| US20110201622A1 (en) | 2011-08-18 |
| AR080203A1 (es) | 2012-03-21 |
| CL2012002285A1 (es) | 2013-01-25 |
| EP2536701A1 (en) | 2012-12-26 |
| JP2013520412A (ja) | 2013-06-06 |
| SG183231A1 (en) | 2012-09-27 |
| JP5746718B2 (ja) | 2015-07-08 |
| AU2011218490B2 (en) | 2014-11-13 |
| IL221430A0 (en) | 2012-10-31 |
| WO2011102793A1 (en) | 2011-08-25 |
| TW201136898A (en) | 2011-11-01 |
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| SREP | Specification republished | ||
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |