CN103140481A - 包含环丙基酰胺衍生物的固体形式 - Google Patents

包含环丙基酰胺衍生物的固体形式 Download PDF

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Publication number
CN103140481A
CN103140481A CN201180019676XA CN201180019676A CN103140481A CN 103140481 A CN103140481 A CN 103140481A CN 201180019676X A CN201180019676X A CN 201180019676XA CN 201180019676 A CN201180019676 A CN 201180019676A CN 103140481 A CN103140481 A CN 103140481A
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China
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approximately
solid form
compound
treatment
schizophrenia
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CN201180019676XA
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Chinese (zh)
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C.D.科林斯
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AstraZeneca AB
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AstraZeneca AB
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Publication of CN103140481A publication Critical patent/CN103140481A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201180019676XA 2010-02-18 2011-02-17 包含环丙基酰胺衍生物的固体形式 Pending CN103140481A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30558110P 2010-02-18 2010-02-18
US61/305,581 2010-02-18
PCT/SE2011/050170 WO2011102793A1 (en) 2010-02-18 2011-02-17 Solid forms comprising a cyclopropyl amide derivative

Publications (1)

Publication Number Publication Date
CN103140481A true CN103140481A (zh) 2013-06-05

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Family Applications (1)

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CN201180019676XA Pending CN103140481A (zh) 2010-02-18 2011-02-17 包含环丙基酰胺衍生物的固体形式

Country Status (17)

Country Link
US (1) US20110201622A1 (enExample)
EP (1) EP2536701A4 (enExample)
JP (1) JP5746718B2 (enExample)
KR (1) KR20130034009A (enExample)
CN (1) CN103140481A (enExample)
AR (1) AR080203A1 (enExample)
AU (1) AU2011218490B9 (enExample)
BR (1) BR112012020780A2 (enExample)
CA (1) CA2789884A1 (enExample)
CL (1) CL2012002285A1 (enExample)
IL (1) IL221430A0 (enExample)
MX (1) MX2012009537A (enExample)
NZ (1) NZ602108A (enExample)
RU (1) RU2012136921A (enExample)
SG (1) SG183231A1 (enExample)
TW (1) TW201136898A (enExample)
WO (1) WO2011102793A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109438423A (zh) * 2018-09-12 2019-03-08 通化师范学院 一种肺癌靶向化合物azd-3759的合成工艺的新方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA101809C2 (uk) 2007-08-22 2013-05-13 Астразенека Аб Похідні циклопропіламіду
TW201039825A (en) * 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
KR20130002316A (ko) * 2010-02-18 2013-01-07 아스트라제네카 아베 시클로프로필 벤즈아미드 유도체의 신규 결정질 형태

Citations (2)

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US20090076020A1 (en) * 2007-08-22 2009-03-19 Astrazeneca Ab Cyclopropyl Amide Derivatives 978
CN102405213A (zh) * 2009-02-20 2012-04-04 阿斯利康(瑞典)有限公司 靶向于组胺h3受体的环丙基酰胺衍生物

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TWI339206B (en) * 2003-09-04 2011-03-21 Vertex Pharma Compositions useful as inhibitors of protein kinases
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CN102405213A (zh) * 2009-02-20 2012-04-04 阿斯利康(瑞典)有限公司 靶向于组胺h3受体的环丙基酰胺衍生物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109438423A (zh) * 2018-09-12 2019-03-08 通化师范学院 一种肺癌靶向化合物azd-3759的合成工艺的新方法

Also Published As

Publication number Publication date
BR112012020780A2 (pt) 2016-05-03
TW201136898A (en) 2011-11-01
WO2011102793A1 (en) 2011-08-25
US20110201622A1 (en) 2011-08-18
MX2012009537A (es) 2012-08-31
RU2012136921A (ru) 2014-03-27
EP2536701A4 (en) 2014-05-07
KR20130034009A (ko) 2013-04-04
SG183231A1 (en) 2012-09-27
EP2536701A1 (en) 2012-12-26
JP2013520412A (ja) 2013-06-06
CA2789884A1 (en) 2011-08-25
JP5746718B2 (ja) 2015-07-08
AU2011218490B2 (en) 2014-11-13
IL221430A0 (en) 2012-10-31
CL2012002285A1 (es) 2013-01-25
AR080203A1 (es) 2012-03-21
AU2011218490B9 (en) 2014-12-18
NZ602108A (en) 2014-09-26
AU2011218490A1 (en) 2012-10-04

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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Application publication date: 20130605