AU2010321784B2 - Recombinant filaggrin polypeptides for cell importation - Google Patents
Recombinant filaggrin polypeptides for cell importation Download PDFInfo
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- AU2010321784B2 AU2010321784B2 AU2010321784A AU2010321784A AU2010321784B2 AU 2010321784 B2 AU2010321784 B2 AU 2010321784B2 AU 2010321784 A AU2010321784 A AU 2010321784A AU 2010321784 A AU2010321784 A AU 2010321784A AU 2010321784 B2 AU2010321784 B2 AU 2010321784B2
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- polypeptide
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- skin
- filaggrin
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- 229940012957 plasmin Drugs 0.000 description 1
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- 238000002331 protein detection Methods 0.000 description 1
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- 235000021075 protein intake Nutrition 0.000 description 1
- 230000003947 protein internalization Effects 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 238000007388 punch biopsy Methods 0.000 description 1
- IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 229940051201 quinoline yellow Drugs 0.000 description 1
- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical compound C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
- 235000012752 quinoline yellow Nutrition 0.000 description 1
- FZUOVNMHEAPVBW-UHFFFAOYSA-L quinoline yellow ws Chemical compound [Na+].[Na+].O=C1C2=CC=CC=C2C(=O)C1C1=NC2=C(S([O-])(=O)=O)C=C(S(=O)(=O)[O-])C=C2C=C1 FZUOVNMHEAPVBW-UHFFFAOYSA-L 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
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- 239000002336 ribonucleotide Substances 0.000 description 1
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- 201000004700 rosacea Diseases 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
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- 230000037390 scarring Effects 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 201000003779 seborrheic infantile dermatitis Diseases 0.000 description 1
- 201000003385 seborrheic keratosis Diseases 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
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- 238000012163 sequencing technique Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- LJFWQNJLLOFIJK-UHFFFAOYSA-N solvent violet 13 Chemical compound C1=CC(C)=CC=C1NC1=CC=C(O)C2=C1C(=O)C1=CC=CC=C1C2=O LJFWQNJLLOFIJK-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000010473 stable expression Effects 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
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- 108091007196 stromelysin Proteins 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical compound NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000010863 targeted diagnosis Methods 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000006177 thiolation reaction Methods 0.000 description 1
- YSMODUONRAFBET-WHFBIAKZSA-N threo-5-hydroxy-L-lysine Chemical compound NC[C@@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-WHFBIAKZSA-N 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229960005196 titanium dioxide Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229940125379 topical corticosteroid Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 101150081616 trpB gene Proteins 0.000 description 1
- 101150111232 trpB-1 gene Proteins 0.000 description 1
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- 241000701447 unidentified baculovirus Species 0.000 description 1
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- 239000011787 zinc oxide Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Rehabilitation Therapy (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014203006A AU2014203006B2 (en) | 2009-11-23 | 2014-06-03 | Recombinant filaggrin polypeptides for cell importation |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26360409P | 2009-11-23 | 2009-11-23 | |
| US61/263,604 | 2009-11-23 | ||
| PCT/US2010/057592 WO2011063320A2 (en) | 2009-11-23 | 2010-11-22 | Recombinant filaggrin polypeptides for cell importation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014203006A Division AU2014203006B2 (en) | 2009-11-23 | 2014-06-03 | Recombinant filaggrin polypeptides for cell importation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2010321784A1 AU2010321784A1 (en) | 2012-05-24 |
| AU2010321784B2 true AU2010321784B2 (en) | 2014-04-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010321784A Revoked AU2010321784B2 (en) | 2009-11-23 | 2010-11-22 | Recombinant filaggrin polypeptides for cell importation |
Country Status (8)
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|---|---|
| US (3) | US10336797B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2504357B1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010321784B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2781537C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2504357T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2645416T3 (cg-RX-API-DMAC7.html) |
| NO (1) | NO2504357T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011063320A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20140170180A1 (en) | 2012-12-17 | 2014-06-19 | Boehringer Ingelheim Vetmedica, Inc. | Porcine parvovirus 5a, methods of use and vaccine |
| US20140234354A1 (en) | 2013-02-15 | 2014-08-21 | Boehringer Ingelheim Vetmedica, Inc. | Porcine parvovirus 5b, methods of use and vaccine |
| WO2015061856A1 (en) | 2013-10-30 | 2015-05-07 | University Of Western Australia | Neuroprotective peptides |
| EP4144756A1 (en) | 2014-05-30 | 2023-03-08 | Azitra, Inc. | Therapeutic treatment of skin disease with recombinant commensal skin microorganisms |
| EP3323827A1 (en) * | 2016-11-21 | 2018-05-23 | Christian-Albrechts-Universität zu Kiel | Cationic intrinsically disordered antimicrobial peptides |
| KR102134414B1 (ko) | 2017-08-04 | 2020-07-15 | 주식회사 케이티 | 액세스 포인트의 신호 세기를 이용하여 위치를 측정하는 장치 및 방법 |
| US12208124B2 (en) * | 2017-09-05 | 2025-01-28 | Azitra Inc. | Methods and compositions for treating inflammatory skin disease with recombinant microorganisms |
| CN112236153B (zh) * | 2018-04-05 | 2025-04-29 | 阿兹特拉公司 | 用重组微生物治疗皮肤疾病的方法和组合物 |
| CA3112633A1 (en) * | 2018-09-26 | 2020-04-02 | Krystal Biotech, Inc. | Compositions and methods for the treatment of skin diseases |
| US11414057B2 (en) * | 2019-04-03 | 2022-08-16 | GM Global Technology Operations LLC | Retractable pedal assembly for a vehicle |
| US20230061804A1 (en) * | 2020-01-23 | 2023-03-02 | The Rockefeller University | Phase separation sensors and uses thereof |
| CN113045638B (zh) * | 2021-04-01 | 2022-04-15 | 芜湖英特菲尔生物制品产业研究院有限公司 | 一种酿酒酵母表达长效重组人丝聚蛋白及其应用 |
| CN118255862B (zh) * | 2024-05-30 | 2024-08-09 | 湖南中科极美生物科技有限公司 | 一种重组人源化丝聚蛋白及其制备方法和应用 |
| KR102886023B1 (ko) * | 2025-03-19 | 2025-11-14 | 주식회사 키프로젠 | 필라그린 단편 단백질을 이용한 융합 필라그린 단편 단백질 및, 이를 함유하는 화장료 조성물 및 약학 조성물 |
| CN119978096B (zh) * | 2025-04-15 | 2025-07-25 | 广州市暨源生物科技有限公司 | 一种具有良好保湿效果的重组人源化丝聚蛋白及其制备方法和应用 |
Citations (2)
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| WO2003078470A1 (en) * | 2002-03-15 | 2003-09-25 | Lg Household & Health Care Ltd. | Fusion peptide grafted with tat peptide to human type-i collagen derived peptide, its preparation method, and cosmetic composition for anti-aging comprising the same |
| US20040186045A1 (en) * | 1999-08-24 | 2004-09-23 | Cellgate, Inc., A Delaware Corporation | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3463302A (en) * | 1967-09-20 | 1969-08-26 | Pearl M Preston | Packaged disposable lotion filled applicator |
| ES2101263T3 (es) | 1993-02-19 | 1997-07-01 | Howard Green | Composiciones que contienen proteinas de corneocitos. |
| US6852686B2 (en) | 1999-06-23 | 2005-02-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for ameliorating icthyosiform skin diseases |
| EP1238104A2 (en) | 1999-11-03 | 2002-09-11 | Metris Therapeutics Limited | Agents implicated in endometriosis |
| WO2002044736A2 (en) | 2000-11-30 | 2002-06-06 | Molecular Skincare Limited | Diagnosis and treatment of epidermal or skin diseases |
| JP2005508832A (ja) * | 2001-02-16 | 2005-04-07 | セルゲイト， インコーポレイテッド | 間隔を開けてアルギニン部分を含むトランスポーター |
| GB0111324D0 (en) | 2001-05-09 | 2001-07-04 | Unilever Plc | Ambient stable beverage |
| EP1432399A1 (en) | 2001-10-04 | 2004-06-30 | Unilever Plc | Enhancing epidermal barrier development in skin |
| IL157786A (en) | 2003-09-07 | 2010-11-30 | Ahava Dead Sea Lab Ltd | Personalized cosmetics |
| KR100659138B1 (ko) | 2005-09-16 | 2006-12-19 | (주)아모레퍼시픽 | 유효성분으로 갈로카테킨 갈레이트를 함유하는 보습용피부외용제 조성물 |
| CA2630587A1 (en) * | 2005-12-01 | 2007-06-07 | Basf Se | Keratin-binding effector molecules containing reactive dyes |
| GB0525492D0 (en) | 2005-12-15 | 2006-01-25 | Univ Dundee | Filaggrin |
| GB0600948D0 (en) | 2006-01-18 | 2006-02-22 | Univ Dundee | Prevention/Treatment Of Ichthyosis Vulgaris, Atopy And Other Disorders |
| JP6175236B2 (ja) | 2009-09-25 | 2017-08-09 | カッパーアールエヌエー，インコーポレイテッド | フィラグリン（ｆｌｇ）の発現および活性の調整によるｆｌｇ関連疾患の処置 |
| FR2968303B1 (fr) | 2010-12-07 | 2013-01-18 | Oreal | Peptides modulateurs du complexe saspase-flg2 |
-
2010
- 2010-11-22 NO NO10832312A patent/NO2504357T3/no unknown
- 2010-11-22 CA CA2781537A patent/CA2781537C/en active Active
- 2010-11-22 US US13/511,267 patent/US10336797B2/en active Active
- 2010-11-22 DK DK10832312.2T patent/DK2504357T3/en active
- 2010-11-22 ES ES10832312.2T patent/ES2645416T3/es active Active
- 2010-11-22 EP EP10832312.2A patent/EP2504357B1/en active Active
- 2010-11-22 WO PCT/US2010/057592 patent/WO2011063320A2/en not_active Ceased
- 2010-11-22 AU AU2010321784A patent/AU2010321784B2/en not_active Revoked
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2019
- 2019-01-08 US US16/242,487 patent/US11098097B2/en active Active
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2020
- 2020-10-12 US US17/068,177 patent/US20210024600A1/en not_active Abandoned
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| US20040186045A1 (en) * | 1999-08-24 | 2004-09-23 | Cellgate, Inc., A Delaware Corporation | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
| WO2003078470A1 (en) * | 2002-03-15 | 2003-09-25 | Lg Household & Health Care Ltd. | Fusion peptide grafted with tat peptide to human type-i collagen derived peptide, its preparation method, and cosmetic composition for anti-aging comprising the same |
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| EP2504357A2 (en) | 2012-10-03 |
| US20190127430A1 (en) | 2019-05-02 |
| ES2645416T3 (es) | 2017-12-05 |
| US11098097B2 (en) | 2021-08-24 |
| CA2781537A1 (en) | 2011-05-26 |
| DK2504357T3 (en) | 2017-10-23 |
| US20130018000A1 (en) | 2013-01-17 |
| AU2010321784A1 (en) | 2012-05-24 |
| WO2011063320A3 (en) | 2011-11-03 |
| US10336797B2 (en) | 2019-07-02 |
| EP2504357B1 (en) | 2017-08-02 |
| US20210024600A1 (en) | 2021-01-28 |
| CA2781537C (en) | 2022-06-28 |
| WO2011063320A2 (en) | 2011-05-26 |
| EP2504357A4 (en) | 2013-09-04 |
| NO2504357T3 (cg-RX-API-DMAC7.html) | 2017-12-30 |
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