AU2010317883B2 - Tricyclic pyrazol amine derivatives - Google Patents

Tricyclic pyrazol amine derivatives Download PDF

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AU2010317883B2
AU2010317883B2 AU2010317883A AU2010317883A AU2010317883B2 AU 2010317883 B2 AU2010317883 B2 AU 2010317883B2 AU 2010317883 A AU2010317883 A AU 2010317883A AU 2010317883 A AU2010317883 A AU 2010317883A AU 2010317883 B2 AU2010317883 B2 AU 2010317883B2
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formula
ethyl
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AU2010317883A1 (en
Inventor
Pascale Gaillard
Isabelle Jeanclaude-Etter
Seenisamy Jeyaprakashnarayanan
Mathilde Muzerelle
Vincent Pomel
Eric Sebille
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Merck Serono SA
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Merck Serono SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
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AU2010317883A 2009-11-13 2010-11-12 Tricyclic pyrazol amine derivatives Active AU2010317883B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09175933.2 2009-11-13
EP09175933 2009-11-13
US26185409P 2009-11-17 2009-11-17
US61/261,854 2009-11-17
PCT/EP2010/067412 WO2011058149A1 (en) 2009-11-13 2010-11-12 Tricyclic pyrazol amine derivatives

Publications (2)

Publication Number Publication Date
AU2010317883A1 AU2010317883A1 (en) 2012-05-03
AU2010317883B2 true AU2010317883B2 (en) 2015-08-06

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AU2010317883A Active AU2010317883B2 (en) 2009-11-13 2010-11-12 Tricyclic pyrazol amine derivatives

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US (1) US9073940B2 (enExample)
EP (1) EP2499146B1 (enExample)
JP (1) JP5735526B2 (enExample)
KR (1) KR20130049766A (enExample)
CN (1) CN102695710B (enExample)
AR (1) AR078979A1 (enExample)
AU (1) AU2010317883B2 (enExample)
CA (1) CA2778174C (enExample)
EA (1) EA201290305A1 (enExample)
ES (1) ES2607952T3 (enExample)
IL (1) IL219602A (enExample)
MX (1) MX2012005518A (enExample)
WO (1) WO2011058149A1 (enExample)
ZA (1) ZA201202641B (enExample)

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CN113754678B (zh) * 2020-06-02 2023-03-10 江苏恒瑞医药股份有限公司 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用
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TW202214655A (zh) * 2020-07-09 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 氧雜氮雜雙環類衍生物、其製備方法及其在醫藥上的應用
US20230234962A1 (en) 2020-07-29 2023-07-27 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Oxa-azaspiro derivative, and preparation method therefor and pharmaceutical use thereof
GB202117511D0 (en) * 2021-12-03 2022-01-19 Ionctura Sa Treatment regimens
CA3212522A1 (en) 2021-03-29 2022-10-06 Zoe Johnson A pi3k-delta inhibitor for the treatment of pancreatic cancer
AU2022251843A1 (en) 2021-03-29 2023-10-05 Ionctura Sa <i>A PI3K-DELTA INHIBITOR FOR USE IN TREATMENT REGIMENS</i>
CN114524828B (zh) * 2022-02-22 2024-07-09 深圳市儿童医院 一种用于治疗神经重症的噻唑衍生物及其应用
CN114524827B (zh) * 2022-02-22 2024-07-09 深圳市儿童医院 一种用于治疗神经重症的吡唑衍生物及其应用
CN115491252B (zh) * 2022-09-29 2023-05-02 江苏四新界面剂科技有限公司 一种宝石切割用低泡润湿剂及其制备方法
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EP2499146B1 (en) 2016-09-21
JP5735526B2 (ja) 2015-06-17
CN102695710A (zh) 2012-09-26
CN102695710B (zh) 2015-08-19
WO2011058149A1 (en) 2011-05-19
ES2607952T3 (es) 2017-04-04
JP2013510825A (ja) 2013-03-28
US20120238545A1 (en) 2012-09-20
AR078979A1 (es) 2011-12-14
IL219602A (en) 2017-04-30
EP2499146A1 (en) 2012-09-19
ZA201202641B (en) 2013-06-26
US9073940B2 (en) 2015-07-07
CA2778174A1 (en) 2011-05-19
MX2012005518A (es) 2012-06-19
AU2010317883A1 (en) 2012-05-03
IL219602A0 (en) 2012-07-31
CA2778174C (en) 2018-02-20
KR20130049766A (ko) 2013-05-14
EA201290305A1 (ru) 2012-12-28

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