ZA201202641B - Tricyclic pyrazol amine derivatives - Google Patents
Tricyclic pyrazol amine derivativesInfo
- Publication number
- ZA201202641B ZA201202641B ZA2012/02641A ZA201202641A ZA201202641B ZA 201202641 B ZA201202641 B ZA 201202641B ZA 2012/02641 A ZA2012/02641 A ZA 2012/02641A ZA 201202641 A ZA201202641 A ZA 201202641A ZA 201202641 B ZA201202641 B ZA 201202641B
- Authority
- ZA
- South Africa
- Prior art keywords
- amine derivatives
- tricyclic
- pyrazol amine
- tricyclic pyrazol
- derivatives
- Prior art date
Links
- -1 pyrazol amine Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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-
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09175933 | 2009-11-13 | ||
| US26185409P | 2009-11-17 | 2009-11-17 | |
| PCT/EP2010/067412 WO2011058149A1 (en) | 2009-11-13 | 2010-11-12 | Tricyclic pyrazol amine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201202641B true ZA201202641B (en) | 2013-06-26 |
Family
ID=41796476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2012/02641A ZA201202641B (en) | 2009-11-13 | 2012-04-12 | Tricyclic pyrazol amine derivatives |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9073940B2 (enExample) |
| EP (1) | EP2499146B1 (enExample) |
| JP (1) | JP5735526B2 (enExample) |
| KR (1) | KR20130049766A (enExample) |
| CN (1) | CN102695710B (enExample) |
| AR (1) | AR078979A1 (enExample) |
| AU (1) | AU2010317883B2 (enExample) |
| CA (1) | CA2778174C (enExample) |
| EA (1) | EA201290305A1 (enExample) |
| ES (1) | ES2607952T3 (enExample) |
| IL (1) | IL219602A (enExample) |
| MX (1) | MX2012005518A (enExample) |
| WO (1) | WO2011058149A1 (enExample) |
| ZA (1) | ZA201202641B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2595623B1 (en) | 2010-07-19 | 2018-02-28 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Use of delta tocopherol for the treatment of lysosomal storage disorders |
| DE102011055815A1 (de) | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
| PL2790705T3 (pl) | 2011-12-15 | 2018-06-29 | Novartis Ag | Zastosowanie inhibitorów czynności lub funkcji PI3K |
| DE102012016908A1 (de) | 2012-08-17 | 2014-02-20 | Aicuris Gmbh & Co. Kg | Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung |
| WO2014078573A2 (en) | 2012-11-16 | 2014-05-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tocopherol and tocopheryl quinone derivatives as correctors of lysosomal storage disorders |
| WO2014121901A1 (en) | 2013-02-07 | 2014-08-14 | Merck Patent Gmbh | Polymorphic forms |
| CN105473596B (zh) * | 2013-06-24 | 2019-04-30 | 默克专利有限公司 | 用作卵泡刺激素受体调节剂的吡唑化合物及其用途 |
| WO2015196335A1 (en) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| WO2017033019A1 (en) | 2015-08-26 | 2017-03-02 | Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii (Cnio) | Condensed tricyclic compounds as protein kinase inhibitors |
| JP7101177B2 (ja) | 2017-01-10 | 2022-07-14 | バイエル・アクチエンゲゼルシヤフト | 有害生物防除剤としてのヘテロサイクレン誘導体 |
| MX2019008230A (es) | 2017-01-10 | 2019-10-24 | Bayer Ag | Derivados heterociclicos como agentes de control de plagas. |
| CN108434150B (zh) * | 2018-02-09 | 2020-03-10 | 天津医科大学总医院 | Zstk474用于制备ean治疗药物的应用 |
| EP3608326A1 (en) * | 2018-08-10 | 2020-02-12 | Irbm S.P.A. | Tricyclic inhibitors of hepatitis b virus |
| CN113754685B (zh) * | 2020-06-02 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| CN113754678B (zh) * | 2020-06-02 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| US20230247994A1 (en) | 2020-07-02 | 2023-08-10 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| CN115835863B (zh) * | 2020-07-09 | 2025-08-12 | 江苏恒瑞医药股份有限公司 | 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用 |
| JP2023536442A (ja) | 2020-07-29 | 2023-08-25 | 江蘇恒瑞医薬股▲ふん▼有限公司 | オキサアザスピロ環系誘導体、その調製方法及びその医薬的応用 |
| GB202117511D0 (en) * | 2021-12-03 | 2022-01-19 | Ionctura Sa | Treatment regimens |
| JP2024511836A (ja) | 2021-03-29 | 2024-03-15 | アイオンクチュラ・ソシエテ・アノニム | 膵臓癌の治療のためのｐｉ３ｋ－デルタ阻害剤 |
| EP4313058B1 (en) | 2021-03-29 | 2025-03-05 | iOnctura SA | Composition comprising roginolisib and dosage regime for treating cancer or an inflammatory or autoimmune disease |
| CN114524827B (zh) * | 2022-02-22 | 2024-07-09 | 深圳市儿童医院 | 一种用于治疗神经重症的吡唑衍生物及其应用 |
| CN114524828B (zh) * | 2022-02-22 | 2024-07-09 | 深圳市儿童医院 | 一种用于治疗神经重症的噻唑衍生物及其应用 |
| CN115491252B (zh) * | 2022-09-29 | 2023-05-02 | 江苏四新界面剂科技有限公司 | 一种宝石切割用低泡润湿剂及其制备方法 |
| CN121175043A (zh) | 2023-03-03 | 2025-12-19 | 伊昂克图拉股份有限公司 | 用于治疗血液恶性肿瘤的罗吉诺利西布与bcl-2抑制剂的组合 |
| CN120916756A (zh) | 2023-03-03 | 2025-11-07 | 伊昂克图拉股份有限公司 | 用于治疗血液恶性肿瘤的罗吉诺利西布与hdac抑制剂的组合 |
| GB202308807D0 (en) | 2023-06-13 | 2023-07-26 | Ionctura Sa | Combinations |
| WO2025073968A1 (en) | 2023-10-06 | 2025-04-10 | Ionctura Sa | Combination of roginolisib with a malt1-gls inhibitor |
| CN120682241A (zh) * | 2024-03-22 | 2025-09-23 | 复旦大学附属中山医院 | 三环骨架化合物及其在制备抗肿瘤药物中的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816467A (en) * | 1987-01-09 | 1989-03-28 | Farmitalia Carlo Erba S.R.L | Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use |
| GB8814586D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation |
| GB8907799D0 (en) * | 1989-04-06 | 1989-05-17 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases |
| GB8916290D0 (en) * | 1989-07-17 | 1989-08-31 | Erba Carlo Spa | Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis |
| JP3542826B2 (ja) | 1994-07-11 | 2004-07-14 | 帝国臓器製薬株式会社 | 新規な二環式化合物縮合［２，１−ｄ］イソキサゾール−３−カルボン酸誘導体 |
| GB9720901D0 (en) * | 1997-10-01 | 1997-12-03 | Pharmacia & Upjohn Spa | Condensed benzothiopyranic compounds |
| FR2800375B1 (fr) * | 1999-11-03 | 2004-07-23 | Sanofi Synthelabo | Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| AU2003255528B2 (en) | 2002-07-10 | 2009-07-16 | Merck Serono Sa | Azolidinone-vinyl fused-benzene derivatives |
| BR0317572A (pt) | 2002-12-20 | 2005-11-22 | Warner Lambert Co | Benzoxazinas e seus derivados como inibidores de pi3ks |
| GB0305152D0 (en) | 2003-03-06 | 2003-04-09 | Novartis Ag | Organic compounds |
| GB0320197D0 (en) | 2003-08-28 | 2003-10-01 | Novartis Ag | Organic compounds |
| RU2007116861A (ru) | 2004-10-07 | 2009-03-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | P13-киназы |
| US8324262B2 (en) | 2005-12-20 | 2012-12-04 | The Brigham And Women's Hospital, Inc. | Tricyclic necrostatin compounds |
| WO2008035356A2 (en) | 2006-09-20 | 2008-03-27 | Glenmark Pharmaceuticals Limited | Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| WO2009010824A1 (en) * | 2007-07-13 | 2009-01-22 | Glenmark Pharmaceuticals, S.A. | Dihydrochromenopyrazole derivatives as vanilloid receptor ligands |
| WO2009071895A1 (en) * | 2007-12-04 | 2009-06-11 | Ucb Pharma S.A. | Fused thiazole and thiophene derivatives as kinase inhibitors |
| AR071112A1 (es) * | 2008-03-31 | 2010-05-26 | Genentech Inc | Derivados de benzopirano y benzoxepina inhibidores de quinasaspi3k, utiles como agentes anticancer,y composiciones farmaceuticas que los contienen. |
-
2010
- 2010-11-12 WO PCT/EP2010/067412 patent/WO2011058149A1/en not_active Ceased
- 2010-11-12 EA EA201290305A patent/EA201290305A1/ru unknown
- 2010-11-12 AR ARP100104189A patent/AR078979A1/es unknown
- 2010-11-12 US US13/509,291 patent/US9073940B2/en active Active
- 2010-11-12 CA CA2778174A patent/CA2778174C/en active Active
- 2010-11-12 MX MX2012005518A patent/MX2012005518A/es not_active Application Discontinuation
- 2010-11-12 ES ES10775841.9T patent/ES2607952T3/es active Active
- 2010-11-12 AU AU2010317883A patent/AU2010317883B2/en active Active
- 2010-11-12 CN CN201080061082.0A patent/CN102695710B/zh active Active
- 2010-11-12 KR KR1020127015183A patent/KR20130049766A/ko not_active Withdrawn
- 2010-11-12 EP EP10775841.9A patent/EP2499146B1/en active Active
- 2010-11-12 JP JP2012538350A patent/JP5735526B2/ja active Active
-
2012
- 2012-04-12 ZA ZA2012/02641A patent/ZA201202641B/en unknown
- 2012-05-06 IL IL219602A patent/IL219602A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130049766A (ko) | 2013-05-14 |
| AU2010317883A1 (en) | 2012-05-03 |
| AU2010317883B2 (en) | 2015-08-06 |
| JP2013510825A (ja) | 2013-03-28 |
| EA201290305A1 (ru) | 2012-12-28 |
| AR078979A1 (es) | 2011-12-14 |
| CA2778174C (en) | 2018-02-20 |
| JP5735526B2 (ja) | 2015-06-17 |
| US9073940B2 (en) | 2015-07-07 |
| CN102695710A (zh) | 2012-09-26 |
| IL219602A (en) | 2017-04-30 |
| CN102695710B (zh) | 2015-08-19 |
| IL219602A0 (en) | 2012-07-31 |
| ES2607952T3 (es) | 2017-04-04 |
| CA2778174A1 (en) | 2011-05-19 |
| US20120238545A1 (en) | 2012-09-20 |
| WO2011058149A1 (en) | 2011-05-19 |
| EP2499146A1 (en) | 2012-09-19 |
| EP2499146B1 (en) | 2016-09-21 |
| MX2012005518A (es) | 2012-06-19 |
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