AU2010306755B2 - Pharmaceutical formulations of nitrite and uses thereof - Google Patents
Pharmaceutical formulations of nitrite and uses thereof Download PDFInfo
- Publication number
- AU2010306755B2 AU2010306755B2 AU2010306755A AU2010306755A AU2010306755B2 AU 2010306755 B2 AU2010306755 B2 AU 2010306755B2 AU 2010306755 A AU2010306755 A AU 2010306755A AU 2010306755 A AU2010306755 A AU 2010306755A AU 2010306755 B2 AU2010306755 B2 AU 2010306755B2
- Authority
- AU
- Australia
- Prior art keywords
- nitrite
- pharmaceutical composition
- human
- pharmaceutically acceptable
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 title claims abstract description 114
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 68
- 150000003839 salts Chemical class 0.000 claims abstract description 33
- 239000000651 prodrug Substances 0.000 claims abstract description 23
- 229940002612 prodrug Drugs 0.000 claims abstract description 23
- 239000012453 solvate Substances 0.000 claims abstract description 20
- 229940005654 nitrite ion Drugs 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims description 56
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- 238000004519 manufacturing process Methods 0.000 claims description 4
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- 229910001959 inorganic nitrate Inorganic materials 0.000 claims description 3
- 239000007909 solid dosage form Substances 0.000 claims description 3
- 239000011247 coating layer Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 113
- 150000002826 nitrites Chemical group 0.000 abstract description 12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25148309P | 2009-10-14 | 2009-10-14 | |
| US61/251,483 | 2009-10-14 | ||
| PCT/US2010/052683 WO2011047161A1 (en) | 2009-10-14 | 2010-10-14 | Pharmaceutical formulations of nitrite and uses thereof |
Publications (2)
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|---|---|
| AU2010306755A1 AU2010306755A1 (en) | 2012-05-03 |
| AU2010306755B2 true AU2010306755B2 (en) | 2015-12-24 |
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Country Status (10)
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| US (4) | US10463689B2 (https=) |
| EP (1) | EP2488035B1 (https=) |
| JP (3) | JP5758904B2 (https=) |
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| CA (1) | CA2777066C (https=) |
| ES (1) | ES2633618T3 (https=) |
| IL (1) | IL219155A0 (https=) |
| IN (1) | IN2012DN03428A (https=) |
| WO (1) | WO2011047161A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008322437B2 (en) | 2007-11-15 | 2013-11-07 | Louisiana State University | Use of nitrite salts in chronic ischemia |
| US20120237617A1 (en) | 2009-06-18 | 2012-09-20 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
| ES2633618T3 (es) | 2009-10-14 | 2017-09-22 | Theravasc Inc. | Formulaciones farmacéuticas de nitrito y sus usos |
| MX388990B (es) | 2011-08-17 | 2025-03-20 | Univ Texas | Método de producción de niveles fisiológicos y terapéuticos de óxido nítrico por medio de un sistema de suministro oral. |
| US8627204B2 (en) * | 2011-10-18 | 2014-01-07 | Microsoft Corporation | Custom optimization of web pages |
| WO2014130691A2 (en) | 2013-02-20 | 2014-08-28 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
| CN105339006A (zh) * | 2013-05-10 | 2016-02-17 | 尼特罗米加公司 | 含有脂肪酸和亚硝酸盐的营养或膳食补充剂 |
| GB201309092D0 (en) | 2013-05-20 | 2013-07-03 | Edixomed Ltd | Transdermal delivery system |
| US20170349438A1 (en) | 2016-06-06 | 2017-12-07 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
| WO2018152509A1 (en) * | 2017-02-20 | 2018-08-23 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Hydrogen sulfide and/or nitrite in the treatment and prevention of atrial fibrillation |
| US11850271B1 (en) * | 2023-05-16 | 2023-12-26 | King Faisal University | Topical skin cream |
| WO2026006722A1 (en) | 2024-06-28 | 2026-01-02 | The Regents Of The University Of Michigan | Nitric oxide generating medical devices and methods |
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| US5994444A (en) * | 1997-10-16 | 1999-11-30 | Medtronic, Inc. | Polymeric material that releases nitric oxide |
| US20070154569A1 (en) * | 2003-07-09 | 2007-07-05 | The Govt. of the U.S.A. through The Dept. of Health and Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
| US20090196930A1 (en) * | 2007-12-27 | 2009-08-06 | Aires Pharmaceuticals, Inc. | Aerosolized nitrite and nitric oxide -donating compounds and uses thereof |
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| US2914446A (en) * | 1958-06-26 | 1959-11-24 | Upjohn Co | Nitrite stabilized ascorbic acid-cyanocobalamin compositions |
| US4650484A (en) | 1983-02-03 | 1987-03-17 | Alza Corporation | Method for treating ischemic conditions |
| IE64726B1 (en) | 1987-11-20 | 1995-08-23 | Elan Corp Plc | Pharmaceutical formulations for preventing drug tolerance |
| US5122384A (en) | 1989-05-05 | 1992-06-16 | Kv Pharmaceutical Company | Oral once-per-day organic nitrate formulation which does not induce tolerance |
| US5278192A (en) | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
| US6709681B2 (en) | 1995-02-17 | 2004-03-23 | Aberdeen University | Acidified nitrite as an antimicrobial agent |
| US20110196039A9 (en) * | 1994-10-05 | 2011-08-11 | Kaesemeyer Wayne H | Controlled release arginine formulations |
| US5648101A (en) | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| US5770645A (en) | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US7371415B1 (en) | 1998-04-03 | 2008-05-13 | The Daily Wellness Company | Method and composition for improving sexual fitness |
| US7015876B1 (en) * | 1998-06-03 | 2006-03-21 | Lear Corporation | Heads-up display with improved contrast |
| WO2000003725A1 (en) | 1998-07-14 | 2000-01-27 | Paracelsian, Inc. | Method for identifying and confirming consistent bio-functionality of natural compositions |
| DE59905248D1 (de) | 1999-01-29 | 2003-05-28 | Disphar Int Bv | Pharmazeutische zusammensetzungen |
| GB9905425D0 (en) | 1999-03-09 | 1999-05-05 | Queen Mary & Westfield College | Pharmaceutical composition |
| US6314956B1 (en) | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
| GB0119011D0 (en) | 2001-08-03 | 2001-09-26 | Univ Aberdeen | Treatment of nail infections |
| EP1492509A1 (en) | 2001-12-18 | 2005-01-05 | ALZA Corporation | Dosage form providing time-varying patterns of drug delivery |
| EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| JP2005524676A (ja) * | 2002-03-20 | 2005-08-18 | ザ・ユニバーシティ・オブ・クイーンズランド | 一酸化窒素供与体及びオピオイド鎮痛薬を含む方法及び組成物 |
| CA2379211A1 (fr) | 2002-03-28 | 2003-09-28 | Institut De Cardiologie De Montreal | Utilisation du bleu de methylene pour renverser la reaction hemodynamique exageree induite par la combinaison d'un derive nitre et du sildenafil ou d'une molecule de meme classe (inhibiteur de la phosphodiesterase) |
| JP2007502831A (ja) | 2003-08-20 | 2007-02-15 | ニトロメッド インコーポレーティッド | ニトロソ化およびニトロシル化心血管化合物、組成物、ならびに使用方法 |
| US20050113409A1 (en) | 2003-09-03 | 2005-05-26 | Pharmacia Corporation | Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith |
| US7362274B1 (en) | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
| US20060083824A1 (en) | 2004-10-20 | 2006-04-20 | Pbm Products Llc | Nutritional supplements for glucose intolerant individuals |
| PL1846058T3 (pl) | 2005-02-11 | 2009-12-31 | Nolabs Ab | Produkt, sposób i zastosowanie go do leczenia neuropatii z wydzielaniem tlenku azotu |
| CN101227916A (zh) | 2005-05-24 | 2008-07-23 | 维尔金有限公司 | 预防和治疗发炎相关状况的组合物和方法 |
| BRPI0621321A2 (pt) * | 2006-02-10 | 2011-12-06 | Mannatech Inc | formulações de suplemento dietético de multivitamìnico e multimineral natural para melhor absorção e utilização biológica |
| GB0607402D0 (en) | 2006-04-12 | 2006-05-24 | Barts & London Nhs Trust | Therapeutic composition and use |
| US8333997B2 (en) | 2006-06-21 | 2012-12-18 | Albert Einstein College Of Medicine Of Yeshiva University | Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof |
| DK2124638T3 (en) | 2007-02-26 | 2017-03-20 | Heartbeet Ltd | COMPOSITION INCREASING PERFORMANCE AND USING IT |
| KR20100014853A (ko) | 2007-02-26 | 2010-02-11 | 존 런드버그 | 아질산염 및 질산염의 신규 용도 및 이를 함유하는 조성물 |
| WO2008153762A2 (en) | 2007-05-25 | 2008-12-18 | N30 Pharmaceuticals, Llc | S-nitrosothiol formulations and storage systems |
| WO2009021058A2 (en) * | 2007-08-06 | 2009-02-12 | Trinity Labortories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| AU2008322437B2 (en) | 2007-11-15 | 2013-11-07 | Louisiana State University | Use of nitrite salts in chronic ischemia |
| WO2010036236A1 (en) | 2008-09-23 | 2010-04-01 | Baker Hughes Incorporated | Anchor assembly |
| US8568793B2 (en) * | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| US20120237617A1 (en) | 2009-06-18 | 2012-09-20 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
| ES2633618T3 (es) | 2009-10-14 | 2017-09-22 | Theravasc Inc. | Formulaciones farmacéuticas de nitrito y sus usos |
| US20130209584A1 (en) | 2009-10-14 | 2013-08-15 | Theravasc Inc. | Pharmaceutical formulations of nitrite and uses thereof |
| US20140127329A1 (en) | 2011-03-31 | 2014-05-08 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Use of nitrites for the treatment of cerebral amyloid angiopathy, age associated dementia, and cognitive decline |
| US20140112983A1 (en) | 2011-04-14 | 2014-04-24 | Theravasc Inc. | Nitrite compositions and uses thereof |
| US9294956B2 (en) | 2011-12-29 | 2016-03-22 | Qualcomm Incorporated | Application-server-assisted preemptive multicast bearer establishment for real-time low-latency applications |
-
2010
- 2010-10-14 ES ES10824097.9T patent/ES2633618T3/es active Active
- 2010-10-14 CN CN201710462544.3A patent/CN107260756A/zh active Pending
- 2010-10-14 JP JP2012534359A patent/JP5758904B2/ja not_active Expired - Fee Related
- 2010-10-14 IN IN3428DEN2012 patent/IN2012DN03428A/en unknown
- 2010-10-14 CN CN2010800568984A patent/CN102686111A/zh active Pending
- 2010-10-14 EP EP10824097.9A patent/EP2488035B1/en active Active
- 2010-10-14 WO PCT/US2010/052683 patent/WO2011047161A1/en not_active Ceased
- 2010-10-14 CA CA2777066A patent/CA2777066C/en active Active
- 2010-10-14 US US12/904,791 patent/US10463689B2/en active Active
- 2010-10-14 AU AU2010306755A patent/AU2010306755B2/en not_active Ceased
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2012
- 2012-04-15 IL IL219155A patent/IL219155A0/en unknown
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2015
- 2015-06-04 JP JP2015113882A patent/JP6125567B2/ja not_active Expired - Fee Related
- 2015-09-08 US US14/847,966 patent/US10307441B2/en active Active
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2017
- 2017-04-05 JP JP2017074888A patent/JP2017141275A/ja active Pending
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2019
- 2019-10-11 US US16/599,710 patent/US20200085861A1/en not_active Abandoned
-
2020
- 2020-06-11 US US16/898,460 patent/US20200297756A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994444A (en) * | 1997-10-16 | 1999-11-30 | Medtronic, Inc. | Polymeric material that releases nitric oxide |
| US20070154569A1 (en) * | 2003-07-09 | 2007-07-05 | The Govt. of the U.S.A. through The Dept. of Health and Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
| US20090196930A1 (en) * | 2007-12-27 | 2009-08-06 | Aires Pharmaceuticals, Inc. | Aerosolized nitrite and nitric oxide -donating compounds and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| US20200085861A1 (en) | 2020-03-19 |
| WO2011047161A1 (en) | 2011-04-21 |
| EP2488035A4 (en) | 2013-07-31 |
| JP2015180674A (ja) | 2015-10-15 |
| EP2488035A1 (en) | 2012-08-22 |
| CN107260756A (zh) | 2017-10-20 |
| US10307441B2 (en) | 2019-06-04 |
| ES2633618T3 (es) | 2017-09-22 |
| US10463689B2 (en) | 2019-11-05 |
| CA2777066A1 (en) | 2011-04-21 |
| IN2012DN03428A (https=) | 2015-10-23 |
| EP2488035B1 (en) | 2017-04-26 |
| US20160067279A1 (en) | 2016-03-10 |
| JP5758904B2 (ja) | 2015-08-05 |
| CA2777066C (en) | 2020-02-18 |
| US20110086069A1 (en) | 2011-04-14 |
| AU2010306755A1 (en) | 2012-05-03 |
| JP2017141275A (ja) | 2017-08-17 |
| IL219155A0 (en) | 2012-06-28 |
| JP6125567B2 (ja) | 2017-05-10 |
| JP2013508289A (ja) | 2013-03-07 |
| US20200297756A1 (en) | 2020-09-24 |
| CN102686111A (zh) | 2012-09-19 |
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