AU2010288273A1 - Polymorphic forms of manidipine - Google Patents

Polymorphic forms of manidipine Download PDF

Info

Publication number
AU2010288273A1
AU2010288273A1 AU2010288273A AU2010288273A AU2010288273A1 AU 2010288273 A1 AU2010288273 A1 AU 2010288273A1 AU 2010288273 A AU2010288273 A AU 2010288273A AU 2010288273 A AU2010288273 A AU 2010288273A AU 2010288273 A1 AU2010288273 A1 AU 2010288273A1
Authority
AU
Australia
Prior art keywords
manidipine
dihydrochloride
base
crystalline form
manidipine dihydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2010288273A
Other languages
English (en)
Inventor
Maruti Ganpati Ghagare
Rajendra Narayanrao Kankan
Dharmaraj Ramachandra Rao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cipla Ltd
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of AU2010288273A1 publication Critical patent/AU2010288273A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AU2010288273A 2009-08-27 2010-08-26 Polymorphic forms of manidipine Abandoned AU2010288273A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1970MU2009 2009-08-27
IN1970/MUM/2009 2009-08-27
PCT/GB2010/001615 WO2011023954A2 (en) 2009-08-27 2010-08-26 Polymorphic forms of manidipine

Publications (1)

Publication Number Publication Date
AU2010288273A1 true AU2010288273A1 (en) 2012-04-12

Family

ID=43530516

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010288273A Abandoned AU2010288273A1 (en) 2009-08-27 2010-08-26 Polymorphic forms of manidipine

Country Status (8)

Country Link
US (1) US9018376B2 (enExample)
EP (1) EP2470505A2 (enExample)
JP (1) JP2013503145A (enExample)
KR (1) KR20130027005A (enExample)
AU (1) AU2010288273A1 (enExample)
CA (1) CA2772499A1 (enExample)
NZ (1) NZ598718A (enExample)
WO (1) WO2011023954A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9018376B2 (en) 2009-08-27 2015-04-28 Cipla Limited Polymorphic forms of manidipine
CN102875451B (zh) * 2012-04-05 2014-12-03 常州制药厂有限公司 一种盐酸马尼地平合成工艺的改进方法
CN103467364B (zh) * 2013-06-21 2015-07-15 四川海思科制药有限公司 一种盐酸马尼地平化合物
CN104292150A (zh) * 2013-07-19 2015-01-21 许昌恒生制药有限公司 一种盐酸马尼地平的合成工艺
CN104447513B (zh) * 2014-11-26 2018-05-29 许昌恒生制药有限公司 一种高纯度盐酸马尼地平β晶型的制备方法
CN108218765A (zh) * 2017-11-24 2018-06-29 扬子江药业集团北京海燕药业有限公司 一种改进盐酸马尼地平ii晶型的生产方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE50987T1 (de) * 1982-05-10 1990-03-15 Takeda Chemical Industries Ltd Dihydropyridinderivate, deren herstellung und verwendung.
WO1983004023A1 (en) * 1982-05-10 1983-11-24 Takeda Chemical Industries, Ltd. Dihydropyridine derivatives
US4994461A (en) 1987-03-27 1991-02-19 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydropyridine enantiomers
ITMI20072226A1 (it) 2007-11-23 2009-05-24 Chiesi Farma Spa Un metodo per determinare la purezza polimorfica di manidipina dicloridrato
US9018376B2 (en) 2009-08-27 2015-04-28 Cipla Limited Polymorphic forms of manidipine

Also Published As

Publication number Publication date
WO2011023954A2 (en) 2011-03-03
JP2013503145A (ja) 2013-01-31
KR20130027005A (ko) 2013-03-14
WO2011023954A3 (en) 2011-04-21
CA2772499A1 (en) 2011-03-03
US20120232091A1 (en) 2012-09-13
US9018376B2 (en) 2015-04-28
EP2470505A2 (en) 2012-07-04
NZ598718A (en) 2014-10-31

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted